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Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures

Published online by Cambridge University Press:  09 July 2009

T. P. Hogan  and
A. G. Awad
T. P. Hogan*
Affiliation:
Queen Street Mental Health Centre and the Department of Psychiatry, University of Toronto, Canada
A. G. Awad
Affiliation:
Queen Street Mental Health Centre and the Department of Psychiatry, University of Toronto, Canada
*
1Address for correspondence: Mr T. P. Hogan, Psychology and Biometrics Section, Schizophrenia Research Program, Queen Street Mental Health Centre, 1001 Queen Street West, Toronto, Canada, M6J 1H4.
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Synopsis

The schizophrenic patient's early psychological response to neuroleptic treatment has been demonstrated to be a significant predictor of treatment response. The validity of the construct of subjective response is evaluated by comparison of two measures. Fifty-five recently admitted and unmedicated schizophrenic patients were randomly allocated to chlorpromazine or haloperidol. Subjective responses at 24 and 48 hours as assessed by two different scales, the Van Putten & May scale and the self-administered Drug Attitude Inventory, were strongly correlated with outcome at three weeks. Early emergence of extrapyramidal symptoms was not related to subjective response, but dysphoric patients had a greater incidence of EPS by the end of treatment than did non-dysphoric patients. The two measures showed high concordance in identification of early drug dysphoria.

Type
Original Articles
Information
Psychological Medicine , Volume 22 , Issue 2 , May 1992 , pp. 347 - 352
Copyright
Copyright © Cambridge University Press 1992

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