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Structural brain imaging abnormalities associated with schizophrenia and partial trisomy of chromosome 5

Published online by Cambridge University Press:  09 July 2009

William G. Honer ,
Anne S. Bassett ,
G. William MacEwan ,
Trevor Hurwitz ,
David K. B. Li ,
Sadek Hilal  and
Isak Prohovnik
William G. Honer*
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Anne S. Bassett
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
G. William MacEwan
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Trevor Hurwitz
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
David K. B. Li
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Sadek Hilal
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Isak Prohovnik
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
*
1Address for correspondence: Dr W. G. Honer, Department of Psychiatry, University of British Columbia, Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada V6K 3Z6.
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Synopsis

Chromosomal abnormalities occurring in association with mental illness provide a unique opportunity to study the interaction of genetic abnormalities and the brain in mental illness. Four individuals from a family in which schizophrenia was found to cosegregate with a partial trisomy of chromosome 5 were studied with computed tomography and magnetic resonance imaging. Temporal lobe atrophy was found in the two trisomic males and in the asymptomatic balanced translocation female. In addition, a large cavum septum pellucidum and a cavum vergae were found in the older trisomic individual. Scans from the normal male were free of abnormalities. These results suggest that molecular studies of the translocation breakpoints in this chromosomal abnormality may be of interest, and encourage further studies of brain structure in other chromosomal abnormalities associated with psychosis.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 22 , Issue 2 , May 1992 , pp. 519 - 524
Copyright
Copyright © Cambridge University Press 1992

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References

Altschuler, L. L., Casanova, M. F., Goldberg, T. E. & Kleinman, J. E. (1990). The hippocampus and parahippocampus in schizophrenia, suicide and control brains. Archives of General Psychiatry 47, 1029–1034.CrossRefGoogle Scholar
Bassett, A. S. (1989). Chromosome 5 and schizophrenia: implications for genetic linkage studies. Schizophrenia Bulletin 15, 393–402.CrossRefGoogle ScholarPubMed
Bassett, A. S. (1992). Autosomal abnormalities in schizophrenia. British Journal of Psychiatry (in the press).Google Scholar
Bassett, A. S., Jones, B. D., McGillivray, B. C. & Pantzar, T. P. (1988). Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet i, 799–801.CrossRefGoogle Scholar
Borrow, J., Goddard, A. D., Sheer, D. & Solomon, E. (1990). Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249, 1577–1580.CrossRefGoogle ScholarPubMed
Davison, K. & Bagley, C. R. (1969). Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In Current Problems in Neuropsychiatry (ed. Herrington, R. N.), pp. 113–184. British Journal of Psychiatry Special Publication No. 4, Headley Brothers: Ashford, Kent.Google Scholar
DeLisi, L. E., Goldin, L. R., Hamovit, J. R., Maxwell, M. E., Kurtz, D. & Gershon, E. S. (1986). A family study of the association of increased ventricular size with schizophrenia. Archives of General Psychiatry 43, 148–153.Google Scholar
de Thé, H., Chomienne, C., Lanotte, M., Degos, L. & Dejean, A. (1990). The t(15: 17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 347, 558–561.CrossRefGoogle Scholar
Fryns, J. P., Kleczkowska, A., Kubien, E. & van den Berghe, H. (1986). Excess of mental retardation and/or congenital malformation in reciprocal translocations in man. Human Genetics 72, 1–8.CrossRefGoogle ScholarPubMed
George, M. S., Scott, S., Kellner, C. H. & Malcolm, R. (1989). Abnormalities of the septum pellucidum in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences 1, 385–390.Google ScholarPubMed
Holland, T. & Gosden, C. (1990). A balanced chromosomal translocation partially co-segregating with psychotic illness in a family. Psychiatry Research 32, 1–8.CrossRefGoogle ScholarPubMed
Iacono, W., Bassett, A. S. & Jones, B. D. (1988). Eye tracking dysfunction is associated with partial trisomy of chromosome 5 and schizophrenia. Archives of General Psychiatry 45, 1140–1141.Google ScholarPubMed
Lewis, S. W. (1989). Congenital risk factors for schizophrenia. Psychological Medicine 19, 5–13.Google Scholar
Lewis, S. W. & Mezey, G. C. (1985). Clinical correlates of septum pellucidum cavities: an unusual association with psychosis. Psychological Medicine 15, 43–54.Google Scholar
McGillivray, B. C., Bassett, A. S., Langlois, S., Pantzar, T. & Wood, S. (1990). Familial 5q11.2–q13.3 segmental duplication cosegregating with multiple anomalies, including schizophrenia. American Journal of Medical Genetics 35, 10–14.CrossRefGoogle ScholarPubMed
Ray, P. N., Belfall, B., Duff, C., Logan, C., Kean, V., Thompson, M. W., Sylvester, J. E., Gorski, J. L., Schmickel, R. D. & Whorton, R. G. (1985). Cloning of the breakpoint of an X; 21 translocation associated with Duchenne muscular dystrophy. Nature 318, 672–675.Google Scholar
Reveley, A. M., Clifford, C. A., Reveley, M. A. & Murray, R. M. (1982). Cerebral ventricular size in twins discordant for schizophrenia. Lancet i, 540–541.CrossRefGoogle Scholar
Risch, N. (1990). Linkage strategies for genetically complex traits. I. Multilocus models. American Journal of Human Genetics 46, 222–228.Google ScholarPubMed
Rutledge, J. C., Cain, K. T., Cacheiro, L. A., Cornett, C. V., Wright, C. G. & Generoso, W. M. (1986). A balanced translocation in mice with a neurological deficit. Science 231, 395–397.CrossRefGoogle Scholar
Uematsu, M. & Kaiya, H. (1989). Midsagittal cortical pathomorphology of schizophrenia: a magnetic resonance imaging study. Psychiatry Research 30, 11–20.Google Scholar
Weinberger, D. R. (1987). Implications of normal brain development for pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660–669.Google Scholar
Weinberger, D. R., DeLisi, L. E., Neophytides, A. N. & Wyatt, R. J. (1981). Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychiatry Research 4, 65–71.CrossRefGoogle ScholarPubMed
Wildi, E., Linder, A. & Costoulas, G. (1967). Schizophrénie et involution cérébrale sénile. Psychiatry and Neurology 154, 41–68.Google ScholarPubMed