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Structural brain imaging abnormalities associated with schizophrenia and partial trisomy of chromosome 5

Published online by Cambridge University Press:  09 July 2009

William G. Honer ,
Anne S. Bassett ,
G. William MacEwan ,
Trevor Hurwitz ,
David K. B. Li ,
Sadek Hilal  and
Isak Prohovnik
William G. Honer*
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Anne S. Bassett
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
G. William MacEwan
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Trevor Hurwitz
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
David K. B. Li
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Sadek Hilal
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
Isak Prohovnik
Affiliation:
Departments of Psychiatry of the University of British Columbia, Vancouver, University of Toronto, Toronto, The College of Physicians and Surgeons, Columbia University, New York; Divisions of Neuroradiology of the University of British Columbia, Vancouver, Neurological Institute, New York; Brain Imaging Division, New York State Psychiatric Institute, New York.
*
1Address for correspondence: Dr W. G. Honer, Department of Psychiatry, University of British Columbia, Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada V6K 3Z6.
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Synopsis

Chromosomal abnormalities occurring in association with mental illness provide a unique opportunity to study the interaction of genetic abnormalities and the brain in mental illness. Four individuals from a family in which schizophrenia was found to cosegregate with a partial trisomy of chromosome 5 were studied with computed tomography and magnetic resonance imaging. Temporal lobe atrophy was found in the two trisomic males and in the asymptomatic balanced translocation female. In addition, a large cavum septum pellucidum and a cavum vergae were found in the older trisomic individual. Scans from the normal male were free of abnormalities. These results suggest that molecular studies of the translocation breakpoints in this chromosomal abnormality may be of interest, and encourage further studies of brain structure in other chromosomal abnormalities associated with psychosis.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 22 , Issue 2 , May 1992 , pp. 519 - 524
Copyright
Copyright © Cambridge University Press 1992

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