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Steroid hormones, the menopause, sexuality and well-being of women

Published online by Cambridge University Press:  09 July 2009

Elizabeth H. H. Cawood*
Affiliation:
MRC Reproductive Biology Unit, Edinburgh
John Bancroft
Affiliation:
MRC Reproductive Biology Unit, Edinburgh
*
1Address for correspondence: Dr Elizabeth H. H. Cawood MRC Reproductive Biology Unit37 Chalmers StreetEdinburgh EH3 9EW.

Synopsis

One hundred and forty-one women, aged 40–60 years, recruited from the community were assessed with an initial interview, plus four interviews at intervals of 1 week and blood samples. The objective was to investigate the determinants of sexuality and well-being in this sample. Measures included interview ratings of sexual function, Frenken Sexual Experience Scales and the Multiple Affect Adjective Check List. Determinants evaluated, using multiple regression analysis, included age, menopausal status, BMI, smoking, ovarian steroids and adrenal androgens. None of the hormonal parameters significantly predicted measures of sexuality; the most important predictors were other aspects of the sexual relationship, sexual attitudes and measures of well-being. The best predictor of both well-being and depression was tiredness. The only hormone positively related to well-being was dehydroepiandrosterone (DHEA).

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1996

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References

Bachmann, G. A. & Leiblum, S. R. (1991). Sexuality in sexagenarian women. Maturitas 13, 4350.CrossRefGoogle ScholarPubMed
Bachmann, G. A., Leiblum, S. R., Kemmann, E., Colburn, D. W., Swartzman, L. & Shelden, R. (1984). Sexual expression and its determinants in the post-menopausal woman. Maturitas 6, 1929.CrossRefGoogle ScholarPubMed
Bancroft, J. (1988). Reproductive hormones and male sexual function. In Handbook of Sexology (ed. Sitsen, J. M. A.), pp. 297315. Elsevier Science Publishers, B. V: Amsterdam.Google Scholar
Bancroft, J. & Cawood, E. H. H. (1996). Androgens and the menopause: a study of 40 to 60 year old women. Clinical Endocrinology (in the press).CrossRefGoogle Scholar
Bancroft, J., Tyrer, G. & Warner, P. (1982). The classification of sexual problems in women. British Journal of Sexual Medicine 9, 3037.Google Scholar
Bancroft, J., Sherwin, B. B., Alexander, G. M., Davidson, D. W.Walker, A. (1991). Oral contraceptives, androgens and the sexuality of women; II The role of androgens. Archives Sexual Behavior 20, 121135.CrossRefGoogle ScholarPubMed
Cauley, J. A., Gutai, J. P., Kuller, L. H. & Powell, J. G. (1991). Reliability and interrelations among serum sex hormones in postmenopausal women. American Journal of Epidemiology 133, 5057.Google ScholarPubMed
Cutler, W. B., Garcia, C. R. & McCoy, N. (1987). Perimenopausal sexuality. Archives of Sexual Behavior 16, 225234.CrossRefGoogle ScholarPubMed
Frenken, J. & Vennix, P. (1981). Sexuality Experience Scales Manual. Swets and Zeitlinger: Lisse, The Netherlands.Google Scholar
Graham, C. A., Ramos, R., Bancroft, J., Maglaya, C. & Farley, T. M. M. (1995). The effects of steroidal contraceptives on the well-being and sexuality of women: a double-blind, placebo-controlled, two centre study of combined and progestogen-only methods. In press Contraception 52, 363369.CrossRefGoogle ScholarPubMed
Greene, J. G. (1976). A factor analytic study of climacteric symptoms. Journal of Psychosomatic Research 20, 425430.CrossRefGoogle ScholarPubMed
Hällström, T. (1973). Mental Disorder and Sexuality in the Climacteric. Scandinavian University Books: Gothenburg.Google Scholar
Hällström, T. & Samuelson, S. (1985). Mental health in the climacteric. Acta Obstetrica et Gynaecologica Scandinavica 130, 1318.CrossRefGoogle ScholarPubMed
Hunter, M. S. (1990). Emotional well-being, sexual behaviour and hormone replacement therapy. Maturitas 12, 299314.CrossRefGoogle ScholarPubMed
Hunter, M. S., Battersby, R. & Whitehead, M. (1986). Relationships between psychological symptoms, somatic complaints and menopausal status. Maturitas 8, 217228.CrossRefGoogle ScholarPubMed
Jazsmann, N. D., van Lith, N. D. & Zat, J. C. A. (1969). The perimenopausal symptoms: a statistical analysis of a survey. Medical Gynaecology and Sociology 4, 268277.Google Scholar
Koster, A. & Garde, K. (1993). Sexual desire and menopausal development. A prospective study of Danish women born in 1936. Maturitas 16, 4960.CrossRefGoogle ScholarPubMed
McCoy, N. L. & Davidson, J. M. (1985). A longitudinal study of the effects of menopause on sexuality. Maturitas 7, 203210.CrossRefGoogle ScholarPubMed
McCoy, N. L., Cutler, W. & Davidson, J. M. (1985). Relationship among sexual behavior, hot flushes, and hormone levels in perimenopausal women. Archives of Sexual Behavior 14, 385394.CrossRefGoogle ScholarPubMed
McKinlay, S., McKinlay, J. & Brambilla, D. (1987). The relative contributions of endocrine changes and social circumstances to depression in mid-aged women. American Journal of Epidemiology 125, 110121.CrossRefGoogle Scholar
Meldrum, D. R., Davidson, B. J., Tataryn, I. V. & Judd, H. L. (1981). Changes in circulating steroids with aging in post-menopausal women. Obstetrics and Gynecology 57, 624628.Google Scholar
Morales, A. J., Nolan, J. J., Nelson, J. C. & Yen, S. S. C. (1994). Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. Journal of Clinical Endocrinology and Metabolism 78, 13601367.Google ScholarPubMed
Osborn, M., Hawton, K. & Gath, D. (1988). Sexual dysfunction among middle-aged women in the community. British Medical Journal 296, 959962.CrossRefGoogle ScholarPubMed
Pfeiffer, E. & Davis, G. C. (1972). Determinants of sexual behavior in middle and old age. Journal of the American Geriatrics Society XX, 151158.CrossRefGoogle Scholar
Sherwin, B. B. (1985). Changes in sexual behavior as a function of plasma sex steroid levels in post-menopausal women. Maturitas 7, 225233.CrossRefGoogle ScholarPubMed
Sherwin, B. B. (1988). Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. Journal of Affective Disorders 14, 177187.CrossRefGoogle ScholarPubMed
Sherwin, B. B. (1991). The psychoendrocrinology of aging and female sexuality. Annual Review of Sex Research II, 181198.Google Scholar
Sherwin, B. B. & Gelfand, M. M. (1985). Sex steroids and affect in the surgical menopause: a double-blind cross-over study. Psychoneuroendocrinology 10, 325335.CrossRefGoogle ScholarPubMed
Sherwin, B. B. & Gelfand, M. M. (1987). The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosomatic Medicine 49, 397409.CrossRefGoogle ScholarPubMed
Tyrer, G., Steel, J. M., Ewing, D. J., Bancroft, J., Warner, P. & Clarke, B. F. (1983). Sexual responsiveness in diabetic women. Diabetologia 24, 166171.CrossRefGoogle ScholarPubMed
Vermeulen, A. & Verdonck, L. (1979). Factors affecting sex hormone levels in postmenopausal women. Journal of Steroid Biochemistry 11, 899904.CrossRefGoogle ScholarPubMed
Zuckerman, M., Lubin, B. & Rinck, C. M. (1983). Construction of new scales for the Multiple Affect Adjective Check List. Journal of Behavioral Assessment 5, 119129.CrossRefGoogle Scholar