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Source monitoring for actions in adolescents with 22q11.2 deletion syndrome (22q11DS)

Published online by Cambridge University Press:  16 November 2007

M. Debbané ,
M. Van der Linden ,
B. Glaser  and
S. Eliez
M. Debbané*
Affiliation:
Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland Faculty of Psychology, University of Geneva, Switzerland
M. Van der Linden
Affiliation:
Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland Faculty of Psychology, University of Geneva, Switzerland
B. Glaser
Affiliation:
Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland Faculty of Psychology, University of Geneva, Switzerland
S. Eliez
Affiliation:
Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland Department of Genetic Medicine and Development, University of Geneva School of Medicine, Switzerland
*
*Address for correspondence: M. Debbané, Service Médico-Pédagogique, Department of Psychiatry, University of Geneva School of Medicine, 16–18 Boulevard St-Georges, Case Postale 50, 1211 Geneva 8, Switzerland. (Email: [email protected])
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Abstract

Background

Source monitoring consists in identifying the origin of mental events. Recent research suggests that confusions over internally generated mental events may represent a cognitive marker for increased proneness to psychotic symptoms and disorders. We have examined source monitoring for actions in adolescents with the 22q11.2 deletion syndrome (22q11DS), a neurogenetic disease associated with high rates of schizophrenia during adulthood, and expected to observe source monitoring deficits in comparison to IQ-matched and typically developing controls.

Method

Eighteen adolescents with 22q11DS, 17 adolescents matched for age and IQ, and also 17 adolescents matched for age participated in this study. Our adapted action monitoring paradigm asked subjects to visualize a series of actions in three different conditions: (1) visualize themselves performing the action; (2) visualize the experimenter performing the action; or (3) simply repeat the action statements without visualization of the action performer.

Results

The adolescents with 22q11DS performed adequately in terms of recognition (hits), but in comparison to both control groups, they committed more source confusions on correctly recognized items. Further examination revealed that the adolescents were more likely to demonstrate confusions between exterior sources in which the self was not involved.

Conclusions

Source monitoring deficits can be observed in adolescents with 22q11DS, a syndrome putting them at high risk for developing schizophrenia. These deficits are discussed in terms of early cognitive processes associated with genetic risk for schizophrenia.

Keywords

Memoryschizophreniaself-monitoringVCFS
Type
Original Articles
Information
Psychological Medicine , Volume 38 , Issue 6 , June 2008 , pp. 811 - 820
Copyright
Copyright © Cambridge University Press 2007

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References

Allen, PP, Johns, LC, Fu, CH, Broome, MR, Vythelingum, GN, McGuire, PK (2004). Misattribution of external speech in patients with hallucinations and delusions. Schizophrenia Research 69, 277–287.CrossRefGoogle ScholarPubMed
Axelrod, SR, Grilo, CM, Sanislow, C, McGlashan, TH (2001). Schizotypal Personality Questionnaire-Brief: factor structure and convergent validity in inpatient adolescents. Journal of Personality Disorders 15, 168–179.CrossRefGoogle ScholarPubMed
Baker, KD, Skuse, DH (2005). Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group. British Journal of Psychiatry 186, 115–120.CrossRefGoogle Scholar
Bassett, AS, Chow, EW, AbdelMalik, P, Gheorghiu, M, Husted, J, Weksberg, R (2003). The schizophrenia phenotype in 22q11 deletion syndrome. American Journal of Psychiatry 160, 1580–1586.CrossRefGoogle ScholarPubMed
Bentall, RP, Baker, GA, Havers, S (1991). Reality monitoring and psychotic hallucinations. British Journal of Clinical Psychology 30, 213–222.CrossRefGoogle ScholarPubMed
Bentall, RP, Kinderman, P, Kaney, S (1994). The self, attributional processes and abnormal beliefs: towards a model of persecutory delusions. Behaviour Research and Therapy 32, 331–341.CrossRefGoogle Scholar
Brébion, G, Amador, X, David, A, Malaspina, D, Sharif, Z, Gorman, JM (2000). Positive symptomatology and source-monitoring failure in schizophrenia – an analysis of symptom-specific effects. Psychiatry Research 95, 119–131.CrossRefGoogle ScholarPubMed
Brébion, G, Gorman, JM, Amador, X, Malaspina, D, Sharif, Z (2002). Source monitoring impairments in schizophrenia: characterisation and associations with positive and negative symptomatology. Psychiatry Research 112, 27–39.CrossRefGoogle ScholarPubMed
Brébion, G, Gorman, JM, Malaspina, D, Amador, X (2005). A model of verbal memory impairments in schizophrenia: two systems and their associations with underlying cognitive processes and clinical symptoms. Psychological Medicine 35, 133–142.CrossRefGoogle Scholar
Brunelin, J, Combris, M, Poulet, E, Kallel, L, D'Amato, T, Dalery, J, Saoud, M (2006). Source monitoring deficits in hallucinating compared to non-hallucinating patients with schizophrenia. European Psychiatry 21, 259–261.CrossRefGoogle ScholarPubMed
Cornblatt, B, Obuchowski, M, Roberts, S, Pollack, S, Erlenmeyer-Kimling, L (1999). Cognitive and behavioral precursors of schizophrenia. Developmental Psychopathology 11, 487–508.CrossRefGoogle ScholarPubMed
Debbané, M, Glaser, B, David, MK, Feinstein, C, Eliez, S (2006 a). Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: neuropsychological and behavioral implications. Schizophrenia Research 84, 187–193.CrossRefGoogle Scholar
Debbané, M, Glaser, B, Eliez, S (in press). Encoding and retrieval processes in velo-cardio-facial syndrome (VCFS). Neuropsychology.Google Scholar
Debbané, M, Schaer, M, Farhoumand, R, Glaser, B, Eliez, S (2006 b). Hippocampal volume reduction in 22q11.2 deletion syndrome. Neuropsychologia 44, 2360–2365.CrossRefGoogle ScholarPubMed
Dumas, P, Bouafia, S, Gutknecht, C, Saoud, M, Dalery, J, d'Amato, T (2000). Validation of the French version of the Raine Schizotypal Personality Disorder Questionnaire – categorical and dimensional approach to schizotypal personality traits in a normal student population [in French]. Encephale 26, 23–29.Google Scholar
Franck, N, Rouby, P, Daprati, E, Dalery, J, Marie-Cardine, M, Georgieff, N (2000). Confusion between silent and overt reading in schizophrenia. Schizophrenia Research 41, 357–364.CrossRefGoogle ScholarPubMed
Freeman, D, Garety, PA, Kuipers, E, Fowler, D, Bebbington, PE (2002). A cognitive model of persecutory delusions. British Journal of Clinical Psychology 41, 331–347.CrossRefGoogle ScholarPubMed
Frith, C, Done, J (1989). Positive symptoms of schizophrenia. British Journal of Psychiatry 154, 569–570.CrossRefGoogle ScholarPubMed
Frith, CD (1992). The Cognitive Neuropsychology of Schizophrenia. Psychology Press Ltd: Hove.Google Scholar
Glaser, B, Mumme, DL, Blasey, C, Morris, MA, Dahoun, SP, Antonarakis, SE, Reiss, AL, Eliez, S (2002). Language skills in children with velocardiofacial syndrome (deletion 22q11.2). Journal of Pediatrics 140, 753–758.CrossRefGoogle ScholarPubMed
Golding-Kushner, KJ, Weller, G, Shprintzen, RJ (1985). Velo-cardio-facial syndrome: language and psychological profiles. Journal of Craniofacial Genetics and Developmental Biology 5, 259–266.Google ScholarPubMed
Gothelf, D, Eliez, S, Thompson, T, Hinard, C, Penniman, L, Feinstein, C, Kwon, H, Jin, S, Jo, B, Antonarakis, SE, Morris, MA, Reiss, AL (2005). COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nature Neuroscience 8, 1500–1502.CrossRefGoogle ScholarPubMed
Henquet, C, Krabbendam, L, Dautzenberg, J, Jolles, J, Merckelbach, H (2005). Confusing thoughts and speech: source monitoring and psychosis. Psychiatry Research 133, 57–63.CrossRefGoogle ScholarPubMed
Johns, LC, van Os, J (2001). The continuity of psychotic experiences in the general population. Clinical Psychology Review 21, 1125–1141.CrossRefGoogle ScholarPubMed
Johnson, MK, Hashtroudi, S, Lindsay, DS (1993). Source monitoring. Psychological Bulletin 114, 3–28.CrossRefGoogle ScholarPubMed
Johnson, MK, Raye, CL (2000). Cognitive and brains mechanisms of false memories and beliefs. In Memory, Brain and Belief (ed. Schacter, D. L. and Scarry, E.), pp. 35–86. Harvard University Press: Cambridge, MA.Google Scholar
Joyce, EM, Roiser, JP (2007). Cognitive heterogeneity in schizophrenia. Current Opinion in Psychiatry 20, 268–272.CrossRefGoogle ScholarPubMed
Kates, WR, Burnette, CP, Jabs, EW, Rutberg, J, Murphy, AM, Grados, M, Geraghty, M, Kaufmann, WE, Pearlson, GD (2001). Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biological Psychiatry 49, 677–684.CrossRefGoogle ScholarPubMed
Kaufman, AS, Kaufman, JC, Balgopal, R, McLean, JE (1996). Comparison of three WISC-III short-forms: weighing psychometric, clinical, and practical factors. Journal of Clinical Child Psychology 25, 97–105.CrossRefGoogle Scholar
Kendler, KS, McGuire, M, Gruenberg, AM, Walsh, D (1994). Clinical heterogeneity in schizophrenia and the pattern of psychopathology in relatives: results from an epidemiologically based family study. Acta Psychiatrica Scandinavica 89, 294–300.CrossRefGoogle ScholarPubMed
Larøi, F, Collignon, O, Van der Linden, M (2005). Source monitoring for actions in hallucination proneness. Cognitive Neuropsychiatry 10, 105–123.Google ScholarPubMed
Larøi, F, Van der Linden, M, Marczewski, P (2004). The effects of emotional salience, cognitive effort and meta-cognitive beliefs on a reality monitoring task in hallucination-prone subjects. British Journal of Clinical Psychology 43, 221–233.CrossRefGoogle ScholarPubMed
Lemos Giraldez, S, Caro, MI, Lopez Rodrigo, AM, Pineiro, MP, Gonzalez, JL (2000). Assessment of essential components of schizotypy using neurocognitive measures. Psychology in Spain 4, 183–194.Google Scholar
Lewandowski, KE, Shashi, V, Berry, PM, Kwapil, TR (2006). Schizophrenic-like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144, 27–36.Google Scholar
Moss, EM, Batshaw, ML, Solot, CB, Gerdes, M, McDonald-McGinn, DM, Driscoll, DA, Emanuel, BS, Zackai, EH, Wang, PP (1999). Psychoeducational profile of the 22q11.2 microdeletion: a complex pattern. Journal of Pediatrics 134, 193–198.CrossRefGoogle ScholarPubMed
Murphy, KC (2005). Annotation: velo-cardio-facial syndrome. Journal of Child Psychology and Psychiatry 46, 563–571.CrossRefGoogle ScholarPubMed
Murphy, KC, Jones, LA, Owen, MJ (1999). High rates of schizophrenia in adults with velo-cardio-facial syndrome. Archives of General Psychiatry 56, 940–945.CrossRefGoogle ScholarPubMed
Oskarsdottir, S, Vujic, M, Fasth, A (2004). Incidence and prevalence of the 22q11 deletion syndrome: a population-based study in Western Sweden. Archives of Disease in Childhood 89, 148–151.CrossRefGoogle ScholarPubMed
Raine, A (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 17, 555–564.CrossRefGoogle ScholarPubMed
Rossi, A, Daneluzzo, E (2002). Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples. Schizophrenia Research 54, 67–75.CrossRefGoogle ScholarPubMed
Saint-Laurent, L (1990). Psychometric study of Kovacs' Children's Depression Inventory with a French-speaking sample [in French]. Canadian Journal of Behavioral Science 22, 377–384.CrossRefGoogle Scholar
Simon, TJ, Bish, JP, Bearden, CE, Ding, L, Ferrante, S, Nguyen, V, Gee, JC, McDonald-McGinn, DM, Zackai, EH, Emanuel, BS (2005 a). A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children. Developmental Psychopathology 17, 753–784.CrossRefGoogle ScholarPubMed
Simon, TJ, Ding, L, Bish, JP, McDonald-McGinn, DM, Zackai, EH, Gee, J (2005 b). Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study. Neuroimage 25, 169–180.CrossRefGoogle ScholarPubMed
Swillen, A, Devriendt, K, Legius, E, Eyskens, B, Dumoulin, M, Gewillig, M, Fryns, JP (1997). Intelligence and psychosocial adjustment in velocardiofacial syndrome: a study of 37 children and adolescents with VCFS. Journal of Medical Genetics 34, 453–458.CrossRefGoogle ScholarPubMed
Swillen, A, Vandeputte, L, Cracco, J, Maes, B, Ghesquiere, P, Devriendt, K, Fryns, JP (1999). Neuropsychological, learning and psychosocial profile of primary school aged children with the velo-cardio-facial syndrome (22q11 deletion): evidence for a nonverbal learning disability? Child Neuropsychology 5, 230–241.CrossRefGoogle ScholarPubMed
Taylor, JL, John, CH (2004). Attentional and memory bias in persecutory delusions and depression. Psychopathology 37, 233–241.CrossRefGoogle ScholarPubMed
Turgeon, L, Chartrand, E (2003). Reliability and Validity of the revised children's manifest anxiety scale in a French–Canadian sample. Psychological Assessment 15, 378–383.CrossRefGoogle Scholar
Vinogradov, S, Willis-Shore, J, Poole, JH, Marten, E, Ober, BA, Shenaut, GK (1997). Clinical and neurocognitive aspects of source monitoring errors in schizophrenia. American Journal of Psychiatry 154, 1530–1537.CrossRefGoogle ScholarPubMed
Vogeley, K, May, M, Ritzl, A, Falkai, P, Zilles, K, Fink, GR (2004). Neural correlates of first-person perspective as one constituent of human self-consciousness. Journal of Cognitive Neuroscience 16, 817–827.CrossRefGoogle ScholarPubMed
Yonelinas, AP (2001). Components of episodic memory: the contribution of recollection and familiarity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 356, 1363–1374.CrossRefGoogle ScholarPubMed