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Source memory errors in schizophrenia, hallucinations and negative symptoms: a synthesis of research findings

Published online by Cambridge University Press:  27 April 2012

G. Brébion ,
R. I. Ohlsen ,
R. A. Bressan  and
A. S. David
G. Brébion*
Affiliation:
Institute of Psychiatry, King's College London, UK
R. I. Ohlsen
Affiliation:
Institute of Psychiatry, King's College London, UK
R. A. Bressan
Affiliation:
Institute of Psychiatry, King's College London, UK
A. S. David
Affiliation:
Institute of Psychiatry, King's College London, UK
*
*Address for correspondence: Dr G. Brébion, Unit of Research and Development, PSSJD, C\Doctor Antoni Pujadas 42, 08830 Sant Boi de Llobregat (Barcelona), Spain. (Email: [email protected])
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Abstract

Background

Previous research has shown associations between source memory errors and hallucinations in patients with schizophrenia. We bring together here findings from a broad memory investigation to specify better the type of source memory failure that is associated with auditory and visual hallucinations.

Method

Forty-one patients with schizophrenia and 43 healthy participants underwent a memory task involving recall and recognition of lists of words, recognition of pictures, memory for temporal and spatial context of presentation of the stimuli, and remembering whether target items were presented as words or pictures.

Results

False recognition of words and pictures was associated with hallucination scores. The extra-list intrusions in free recall were associated with verbal hallucinations whereas the intra-list intrusions were associated with a global hallucination score. Errors in discriminating the temporal context of word presentation and the spatial context of picture presentation were associated with auditory hallucinations. The tendency to remember verbal labels of items as pictures of these items was associated with visual hallucinations. Several memory errors were also inversely associated with affective flattening and anhedonia.

Conclusions

Verbal and visual hallucinations are associated with confusion between internal verbal thoughts or internal visual images and perception. In addition, auditory hallucinations are associated with failure to process or remember the context of presentation of the events. Certain negative symptoms have an opposite effect on memory errors.

Keywords

Hallucinationsschizophreniasource memory
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 12 , December 2012 , pp. 2543 - 2554
Copyright
Copyright © Cambridge University Press 2012

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References

Aleman, A, Nieuwenstein, MR, Bocker, KBE, de Haan, EHF (2000). Mental imagery and perception in hallucination-prone individuals. Journal of Nervous and Mental Disease 188, 830–836.CrossRefGoogle ScholarPubMed
Allen, P, Larøi, F, McGuire, PK, Aleman, A (2008). The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations. Neuroscience and Biobehavioral Reviews 32, 175–191.CrossRefGoogle Scholar
Badcock, JC, Hugdahl, K (2012). Cognitive mechanisms of auditory verbal hallucinations in psychotic and non-psychotic groups. Neuroscience and Biobehavioral Reviews 36, 431–438.CrossRefGoogle ScholarPubMed
Barkus, E, Stirling, J, Hopkins, R, McKie, S, Lewis, S (2007). Cognitive and neural processes in non-clinical auditory hallucinations. British Journal of Psychiatry 191 (Suppl. 51), s76–s81.CrossRefGoogle Scholar
Bentall, RP (1990). The illusion of reality: a review and integration of psychological research on hallucinations. Psychological Bulletin 107, 82–95.CrossRefGoogle ScholarPubMed
Bentall, RP, Slade, PD (1985). Reality testing and auditory hallucinations: a signal detection analysis. British Journal of Clinical Psychology 24, 159–169.CrossRefGoogle ScholarPubMed
Brébion, G, Amador, X, David, A, Malaspina, D, Sharif, Z, Gorman, J (2000). Positive symptomatology and source-monitoring failure in schizophrenia – an analysis of symptom-specific effects. Psychiatry Research 95, 119–131.CrossRefGoogle ScholarPubMed
Brébion, G, Bressan, RA, Ohlsen, RI, Pilowsky, LS, David, AS (2010 b). Production of atypical category exemplars in patients with schizophrenia. Journal of the International Neuropsychological Society 16, 822–828.CrossRefGoogle ScholarPubMed
Brébion, G, David, AS, Bressan, RA, Ohlsen, RI, Pilowsky, LS (2009). Hallucinations and two types of free-recall intrusion in schizophrenia. Psychological Medicine 39, 917–926.CrossRefGoogle ScholarPubMed
Brébion, G, David, AS, Jones, HM, Ohlsen, R, Pilowsky, LS (2007 a). Temporal context discrimination in patients with schizophrenia: associations with auditory hallucinations and negative symptoms. Neuropsychologia 45, 817–823.CrossRefGoogle ScholarPubMed
Brébion, G, David, AS, Jones, H, Pilowsky, LS (2005). Hallucinations, negative symptoms, and response bias in a verbal recognition task in schizophrenia. Neuropsychology 19, 612–617.CrossRefGoogle Scholar
Brébion, G, David, AS, Ohlsen, R, Jones, HM, Pilowsky, LS (2007 b). Visual memory errors in schizophrenic patients with auditory and visual hallucinations. Journal of the International Neuropsychological Society 13, 832–838.CrossRefGoogle ScholarPubMed
Brébion, G, Gorman, J, Amador, X, Malaspina, D, Sharif, Z (2002). Source monitoring impairments in schizophrenia: characterisation and associations with positive and negative symptomatology. Psychiatry Research 112, 27–39.CrossRefGoogle ScholarPubMed
Brébion, G, Larøi, F, van der Linden, M (2010 a). Associations of hallucination proneness with free-recall intrusions and response bias in a nonclinical sample. Journal of Clinical and Experimental Neuropsychology 32, 847–854.CrossRefGoogle Scholar
Brébion, G, Ohlsen, RI, Pilowsky, LS, David, AS (2008). Visual hallucinations in schizophrenia: confusion between imagination and perception. Neuropsychology 22, 383–389.CrossRefGoogle ScholarPubMed
Brébion, G, Smith, M, Amador, X, Malaspina, D, Gorman, J (1998). Word recognition, discrimination accuracy, and decision bias in schizophrenia: association with positive symptomatology and depressive symptomatology. Journal of Nervous and Mental Disease 186, 604–609.CrossRefGoogle ScholarPubMed
Diaz-Asper, C, Malley, J, Genderson, M, Apud, J, Elvevåg, B (2008). Context binding in schizophrenia: effects of clinical symptomatology and item content. Psychiatry Research 159, 259–270.CrossRefGoogle ScholarPubMed
Ditman, T, Kuperberg, GR (2005). A source-monitoring account of auditory verbal hallucinations in patients with schizophrenia. Harvard Review of Psychiatry 13, 280–299.CrossRefGoogle ScholarPubMed
Doré, M-C, Caza, N, Gingras, N, Maziade, M, Rouleau, N (2009). Effects of phonological and semantic cuing on encoding and retrieval processes in adolescent psychosis. Journal of Clinical and Experimental Neuropsychology 31, 533–544.CrossRefGoogle ScholarPubMed
Franck, N, Rouby, P, Daprati, E, Daléry, J, Marie-Cardine, M, Georgieff, N (2000). Confusion between silent and overt reading in schizophrenia. Schizophrenia Research 41, 357–364.CrossRefGoogle ScholarPubMed
Heinrichs, RW, McDermid Vaz, S (2004). Verbal memory errors and symptoms in schizophrenia. Cognitive and Behavioral Neurology 17, 98–101.CrossRefGoogle ScholarPubMed
Hemsley, DR (2005). The schizophrenic experience: taken out of context? Schizophrenia Bulletin 31, 43–53.CrossRefGoogle ScholarPubMed
Johnson, MK, Hashtroudi, S, Lindsay, DS (1993). Source monitoring. Psychological Bulletin 114, 3–28.CrossRefGoogle ScholarPubMed
Jones, SR (2010). Do we need multiple models of auditory verbal hallucinations? Examining the phenomenological fit of cognitive and neurological models. Schizophrenia Bulletin 36, 566–575.CrossRefGoogle ScholarPubMed
Larøi, F, van der Linden, M, Marczewski, P (2004). The effects of emotional salience, cognitive effort and meta-cognitive beliefs on a reality monitoring task in hallucination-prone subjects. British Journal of Clinical Psychology 43, 221–233.CrossRefGoogle ScholarPubMed
Larøi, F, Woodward, TS (2007). Hallucinations from a cognitive perspective. Harvard Review of Psychiatry 15, 109–117.CrossRefGoogle ScholarPubMed
Minor, KS, Cohen, AS, Weber, CR, Brown, LA (2011). The relationship between atypical semantic activation and odd speech in schizotypy across emotionally evocative conditions. Schizophrenia Research 126, 144–149.CrossRefGoogle ScholarPubMed
Moritz, S, Heeren, D, Andresen, B, Krausz, M (2001). An analysis of the specificity and the syndromal correlates of verbal memory impairments in schizophrenia. Psychiatry Research 101, 23–31.CrossRefGoogle ScholarPubMed
Rankin, PM, O'Carroll, PJ (1995). Reality discrimination, reality monitoring and disposition towards hallucination. British Journal of Clinical Psychology 34, 517–528.CrossRefGoogle ScholarPubMed
Seal, ML, Aleman, A, McGuire, PK (2004). Compelling imagery, unanticipated speech and deceptive memory: neurocognitive models of auditory verbal hallucinations in schizophrenia. Cognitive Neuropsychiatry 9, 43–72.CrossRefGoogle ScholarPubMed
Servan-Schreiber, D, Cohen, JD, Steingard, S (1996). Schizophrenic deficits in the processing of context. A test of a theoretical model. Archives of General Psychiatry 53, 1105–1112.CrossRefGoogle ScholarPubMed
Soriano, MF, Jiménez, JF, Román, P, Bajo, MT (2009). Intentional inhibition in memory and hallucinations: directed forgetting and updating. Neuropsychology 23, 61–70.CrossRefGoogle ScholarPubMed
Stirling, JD, Hellewell, JSE, Ndlovu, D (2001). Self-monitoring dysfunction and the positive symptoms of schizophrenia. Psychopathology 34, 198–202.CrossRefGoogle ScholarPubMed
Talamini, LM, de Haan, L, Nieman, DH, Linszen, DH, Meeter, M (2010). Reduced context effects on retrieval in first-episode schizophrenia. PLoS ONE 5, e10356.CrossRefGoogle ScholarPubMed
Turetsky, BI, Moberg, PJ, Mozley, LH, Moelter, ST, Agrin, RN, Gur, RC, Gur, RE (2002). Memory-delineated subtypes of schizophrenia: relationship to clinical, neuroanatomical, and neurophysiological measures. Neuropsychology 16, 481–490.CrossRefGoogle ScholarPubMed
Varese, F, Barkus, E, Bentall, RP (2011). Dissociative and metacognitive factors in hallucination-proneness when controlling for comorbid symptoms. Cognitive Neuropsychiatry 16, 193–217.CrossRefGoogle ScholarPubMed
Waters, FAV, Badcock, JC, Maybery, MT, Michie, PT (2003). Inhibition in schizophrenia: association with auditory hallucinations. Schizophrenia Research 62, 275–280.CrossRefGoogle ScholarPubMed
Waters, FAV, Badcock, JC, Michie, PT, Maybery, MT (2006). Auditory hallucinations in schizophrenia: intrusive thoughts and forgotten memories. Cognitive Neuropsychiatry 11, 65–83.CrossRefGoogle ScholarPubMed
Waters, F, Woodward, T, Allen, P, Aleman, A, Sommer, I (2012). Self-recognition deficits in schizophrenia patients with auditory hallucinations: a meta-analysis of the literature. Schizophrenia Bulletin. Published online 8 December 2010. doi:10.1093/schbul/sbq144.CrossRefGoogle ScholarPubMed