Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-16T17:23:53.237Z Has data issue: false hasContentIssue false

The social outcome of patients in a trial of long-term continuation therapy in schizophrenia: pimozide vs. fluphenazine

Published online by Cambridge University Press:  09 July 2009

I. Falloon
Affiliation:
St John's Hospital, Stone, Aylesbury and the Institute of Psychiatry, London
D. C. Watt
Affiliation:
St John's Hospital, Stone, Aylesbury and the Institute of Psychiatry, London
M. Shepherd*
Affiliation:
St John's Hospital, Stone, Aylesbury and the Institute of Psychiatry, London
*
1Address for correspondence: Professor M. Shepherd, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.

Synopsis

A blind social assessment at home was carried out twice during a year's follow-up of 41 patients on continuation therapy, 21 randomly allocated to pimozide tablets and 20 to fluphenazine decanoate injections. Patients on pimozide were significantly more favourably rated on aspects of sociability, use of leisure, warmth of personal relationships, household tasks and child-rearing. The mode of production of this result is discussed.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abuzzahab, F. S. Sr & Zimmerman, R. L. (1976). A three-year double-blind investigation of pimozide versus fluphenazine in chronic schizophrenia. Psychopharmacology Bulletin 12, 2627.Google ScholarPubMed
Andrews, W. N. (1973). Long-acting tranquillizers and the amotivational syndrome in the treatment of schizophrenia. In Community Management of the Schizophrenic in Chemical Remission (ed. King, M. H.), pp. 14. Excerpta Medica: Amsterdam.Google Scholar
Argyle, M., Trower, P. & Bryant, B. (1974). Explorations in the treatment of personality disorders and neuroses by social skills training. British Journal of Medical Psychology 47, 6372.CrossRefGoogle ScholarPubMed
Baro, F., Van Lommel, R., Dorn, R. & De Mesmaecker, L. (1972). Pimozide treatment of chronic schizophrenics as compared with haloperidol and penfluridol maintenance treatment. Acta Psychiatrica Belgique 72, 199214.Google ScholarPubMed
Chouinard, C., Lehmann, H. E. & Ban, T. A. (1970). Pimozide in the treatment of chronic schizophrenic patients. Current Therapeutic Research 12, 598.Google ScholarPubMed
Engelhardt, D. M. & Freedman, N. (1970). Maintenance drug therapy: the schizophrenic patient in the community. In Social Psychiatry (ed. Kiev, Ari), pp. 256282. Routledge and Kegan Paul: London.Google Scholar
Espvall, M., Perris, C. & Rapp, W. (1974). Measurements of performance in chronic schizophrenic patients treated with pimozide. Acta Psychiatrica Scandinavica Supplement 249, 8793.CrossRefGoogle ScholarPubMed
Falloon, I. R. H., Watt, D. C. & Shepherd, M. (1978). A comparative controlled trial of pimozide and fluphenazine decanoate in the continuation therapy of schizophrenia. Psychological Medicine 8, 5970.CrossRefGoogle ScholarPubMed
Finney, D. J., Latscha, R., Bennett, B. M. & Hsu, P. (1963). Tables for Testing Significance in a 2 × 2 Contingency Table. Cambridge University Press: London.Google Scholar
Hirsch, S. R., Gaind, R., Rohde, P. D., Stevens, B. C. & Wing, J. K. (1973). Outpatient maintenance of chronic schizophrenic patients with long-acting fluphenazine: double-blind placebo trial. British Medical Journal i, 633637.CrossRefGoogle Scholar
Hogarty, G. E., Solomon, S. C., Schooler, N. & Ulrich, R. F. (1974 a). Drug and sociotherapy in the after-care of schizophrenic patients. II. Two-year relapse rates. Archives of General Psychiatry 31, 603608.CrossRefGoogle ScholarPubMed
Hogarty, G. E., Goldberg, S. C. & Schooler, N. R. (1974 b). Drug and sociotherapy in the after-care of schizophrenic patients. III. Adjustment of non-relapsed patients. Archives of General Psychiatry 31, 609618.CrossRefGoogle Scholar
Katz, M. M. & Lyerly, S. B. (1963). Methods of measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. Psychological Reports 13, 503535.CrossRefGoogle Scholar
Kolivakis, T., Azim, H. & Kingstone, E. (1974). A double-blind comparison of pimozide and chlorpromazine in the maintenance care of chronic schizophrenic outpatients. Current Therapeutic Research 16, 998.Google ScholarPubMed
Lapierre, Y. D. & Lavallee, J. (1975). Pimozide and the social behaviour of schizophrenics. Current Therapeutic Research 18, 181188.Google ScholarPubMed
Pinder, R. M., Brogden, R. N., Sawyer, P. R., Speight, T. M., Spencer, R. & Avery, G. S. (1976). Pimozide: a review of its pharmacological properties and therapeutic uses in psychiatry. Drugs 12, 140.CrossRefGoogle ScholarPubMed
Sims, A. C. P. & Burnside, I. G. (1975). Activity in chronic schizophrenic patients: comparison of pimozide with fluphenazine in a double-blind trial. Psychological Medicine 5, 161164.CrossRefGoogle Scholar
Stevens, B. C. (1972). Dependence of schizophrenic patients on elderly relatives. Psychological Medicine 2, 1732.CrossRefGoogle ScholarPubMed
Stevens, B. C. (1973). Role of fluphenazine decanoate in lessening the burden of chronic schizophrenics on the community. Psychological Medicine 3, 141158.CrossRefGoogle ScholarPubMed
Stevens, B. C. (1976). The social value of fluphenazine decanoate. Acta Psychiatrica (Belgium) 76, 792804.Google ScholarPubMed
Vaughn, C. E. & Leff, J. P. (1976). The influence of family and social factors on the course of psychiatric illness: a comparison of schizophrenic and depressed neurotic patients. British Journal of Psychiatry 129, 125137.CrossRefGoogle ScholarPubMed