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Shifted inferior frontal laterality in women with major depressive disorder is related to emotion-processing deficits

Published online by Cambridge University Press:  08 January 2013

E. M. Briceño ,
S. L. Weisenbach ,
L. J. Rapport ,
K. E. Hazlett ,
L. A. Bieliauskas ,
B. D. Haase ,
M. T. Ransom ,
M. L. Brinkman ,
M. Peciña  and
D. E. Schteingart
...Show all authors
E. M. Briceño
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA Department of Psychology, Wayne State University, Detroit, MI, USA
S. L. Weisenbach
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA Ann Arbor VA Medical Center, Ann Arbor, MI, USA
L. J. Rapport
Affiliation:
Department of Psychology, Wayne State University, Detroit, MI, USA
K. E. Hazlett
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
L. A. Bieliauskas
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA Ann Arbor VA Medical Center, Ann Arbor, MI, USA
B. D. Haase
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
M. T. Ransom
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
M. L. Brinkman
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
M. Peciña
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
D. E. Schteingart
Affiliation:
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
M. N. Starkman
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
B. Giordani
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
R. C. Welsh
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
D. C. Noll
Affiliation:
Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
J.-K. Zubieta
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA
S. A. Langenecker*
Affiliation:
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA
*
*Address for correspondence: S. A. Langenecker, Ph.D., Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Room 579, Chicago, IL 60126, USA. (Email: [email protected])
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Abstract

Background

Facial emotion perception (FEP) is a critical human skill for successful social interaction, and a substantial body of literature suggests that explicit FEP is disrupted in major depressive disorder (MDD). Prior research suggests that weakness in FEP may be an important phenomenon underlying patterns of emotion-processing challenges in MDD and the disproportionate frequency of MDD in women.

Method

Women with (n = 24) and without (n = 22) MDD, equivalent in age and education, completed a FEP task during functional magnetic resonance imaging.

Results

The MDD group exhibited greater extents of frontal, parietal and subcortical activation compared with the control group during FEP. Activation in the inferior frontal gyrus (IFG) appeared shifted from a left >right pattern observed in healthy women to a bilateral pattern in MDD women. The ratio of left to right suprathreshold IFG voxels in healthy controls was nearly 3:1, whereas in the MDD group, there was a greater percentage of suprathreshold IFG voxels bilaterally, with no leftward bias. In MDD, relatively greater activation in right IFG compared with left IFG (ratio score) was present and predicted FEP accuracy (r = 0.56, p < 0.004), with an inverse relationship observed between FEP and subgenual cingulate activation (r = − 0.46, p = 0.02).

Conclusions

This study links, for the first time, disrupted IFG activation laterality and increased subgenual cingulate activation with deficient FEP in women with MDD, providing an avenue for imaging-to-assessment translational applications in MDD.

Keywords

Depressionemotionfaceslateralityidentificationneuroimagingwomen
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 7 , July 2013 , pp. 1433 - 1445
Copyright
Copyright © Cambridge University Press 2013 

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