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Sampling strategy in linkage studies of affective disorders

Published online by Cambridge University Press:  09 July 2009

M. Leboyer ,
M. C. Babron  and
F. Clerget-Darpoux
M. Leboyer*
Affiliation:
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
M. C. Babron
Affiliation:
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
F. Clerget-Darpoux
Affiliation:
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
*
1Address for correspondence: Dr M. Leboyer, INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Château de Longchamp, Bois de Boulogne, Paris 75016, France.
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Synopsis

Evidence of linkage in families of bipolar patients has so far been identified with genetic markers on chromosome X and 11. However, replications of these data have not consistently been reported in either case, which favours the hypothesis of genetic heterogeneity. Therefore, we have tried to outline a sampling strategy for linkage replication in affective disorders. We estimated the average number of nuclear families required to replicate X or 11 linkage as a function of the degree of heterogeneity as well as the number to prove heterogeneity given that linkage exists. The results are presented and discussed.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 3 , August 1990 , pp. 573 - 579
Copyright
Copyright © Cambridge University Press 1990

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References

Baron, M. (1977). Linkage between an X-chromosome marker (deutan color blindness) and bipolar affective illness. Archives of General Psychiatry 24, 721–727.Google Scholar
Baron, M., Risch, N., Hamburger, R., Mandel, B., Kushner, S., Newman, M., Drumer, D. & Belmaker, R. (1987). Genetic linkage between X chromosome markers and bipolar affective illness. Nature 326, 289–292.CrossRefGoogle ScholarPubMed
Botstein, D., White, R., Skolnick, M. & Davis, R. (1980). Construction of a genetic linkage map using restriction fragment length polymorphisms. American Journal of Human Genetics 32, 314–331.Google ScholarPubMed
Cavalli-Sforza, L. & King, M. C. (1986). Detecting linkage for genetically heterogeneous disease and detecting heterogeneity with linkage data. American Journal of Human Genetics 38, 599–616.Google ScholarPubMed
Clerget-Darpoux, F., Babron, M.-C. & Bonaiti, C. (1987). Power and robustness of the linkage homogeneity test in genetic analysis of common disorder. Journal of Psychiatric Research 21, 625–630.Google Scholar
Detera-Wadleigh, S. D., Berrettini, W. H., Goldin, L., Boorman, D., Anderson, S. & Gershon, E. S. (1987). Close linkage of C-Harvey- Ras and the insulin gene to affective disorders is ruled out in three North American pedigrees. Nature 325, 806–808.CrossRefGoogle ScholarPubMed
Egeland, J. A., Gerhard, D. S., Pauls, D. L., Sussex, J. N., Kidd, K. K., Allen, C. R., Hostetter, A. M. & Housman, D. E. (1987). Bipolar affective disorders linked to DNA markers on chromosome II. Nature 325, 783–787.CrossRefGoogle Scholar
Gershon, E. S. & Goldin, L. R. (1987). The outlook for linkage research in psychiatric disorders. Journal of Psychiatry Research 21, 541–550.Google Scholar
Gershon, E. S., Targum, S. D., Matthysse, S. & Bunney, W. E. (1979). Colour blindness not closely linked to bipolar illness. Archives of General Psychiatry 36, 1423–1430.CrossRefGoogle Scholar
Gill, M., McKeon, P. & Humphries, P. (1988). Linkage analysis of manic-depression in an Irish family using H-RasI and INS DNA markers. Journal of Medical Genetics 25, 634–637.Google Scholar
Goldin, L. & Gershon, E. (1988 a). Power of the affected sib-pair method for heterogeneous disorders. Genetic Epidemiology 5, 35–42.CrossRefGoogle ScholarPubMed
Goldin, L. & Gershon, E. (1988 b). The genetic epidemiology of major depressive illness. In American Psychiatric Press Review of Psychiatry, Vol. 7 (ed. Frances, A. J. and Hales, R. E.), pp. 149–168. American Psychiatric Press: Washington, DC.Google Scholar
Goldin, L. R., Cox, N. J., Gershon, E. S. & Kidd, K. K. (1984). The detection of major loci by segregation and linkage analysis: a simulation study. Genetic Epidemiology 1, 285–296.CrossRefGoogle ScholarPubMed
Hodgkinson, S., Sherrington, R., Gurling, H., Marchbanks, R., Reeders, S., Mallet, J., McInnis, M., Petursson, H. & Brynjolfsson, J. (1987). Molecular genetic evidence of heterogeneity in manic depression. Nature 325, 805–806.CrossRefGoogle ScholarPubMed
Kidd, K. K., Egeland, J., Molthan, L., Pauls, D., Kruger, S., Phil, M. & Messner, K. (1984). Amish study. IV. Genetic linkage study of pedigrees of bipolar probands. American Journal of Psychiatry 141, 1042–1048.Google ScholarPubMed
Leckman, J., Gershon, E. S., McGinniss, M. H., Targum, S. D. & Dibble, E. D. (1979). New data do not suggest linkage between the Xg blood group and bipolar illness. Archives of General Psychiatry 36, 1436–1441.Google Scholar
McGuffin, P. & Katz, R. (1986). Nature, nurture and affective disorders. In The Biology of Depression (ed. Deakin, J. F. W.), pp. 27–51. Gaskell Royal College of Psychiatrists: London.Google Scholar
Mendlewicz, J. & Fleiss, J. L. (1974). Linkage studies with X-chromosome markers in bipolar (manic-depressive) and unipolar depressive illness. Journal of Biological Psychiatry 9, 261–294.Google Scholar
Mendlewicz, J., Linkowski, P. & Wilmotte, J. (1980). Linkage between glucose-6-phosphate dehydrogenase deficiency and manic-depressive illness: new evidence. British Journal of Psychiatry 137, 337–342.CrossRefGoogle Scholar
Mendlewicz, J., Simon, P., Sevy, S., Charon, F., Brocas, H., Legros, S. & Vassart, G. (1987). Polymorphic DNA marker on X chromosome and manic depression. Lancet. i, 1230–1232.Google Scholar
Morton, N. E. (1955). Sequential tests for the detection of linkage. American Journal of Human Genetics 7, 277–318.Google ScholarPubMed
Neyman, J. & Pearson, E. S. (1928). On the use and interpretation of certain trait criteria for purposes of statistical inferences. Biometrica 20A, 175–263.Google Scholar
O'Rourke, D. H., McGuffin, P. & Reich, T. (1984). Genetic analysis of manic-depressive illness. American Journal of Physical Anthropology 62, 51–59.Google Scholar
Risch, N. & Baron, M. (1982). X-linkage and genetic heterogeneity in bipolar related major affective illness: re-analysis of linkage data. Annals of Human Genetics 46, 153–166.CrossRefGoogle Scholar
Smith, C. A. B. (1963). Testing for heterogeneity of recombination fraction values in human genetics. Annals of Human Genetics 27, 175–182.CrossRefGoogle ScholarPubMed
Winokur, G. & Tanna, V. (1969). Possible role of X-linked dominant factor in manic-depressive disease. Diseases of the Nervous System 30, 89–96.Google Scholar