Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-16T15:03:45.135Z Has data issue: false hasContentIssue false
  • English
  • Français

Salience and psychosis: moving from theory to practise

A commentary on: ‘Do patients with schizophrenia exhibit aberrant salience?’ by Roiser et al. (2008)

Published online by Cambridge University Press:  12 August 2008

J. Jensen  and
S. Kapur
J. Jensen
Affiliation:
Department of Psychiatry, University of Oslo, Oslo, Norway Department of Psychiatry, Ullevål University Hospital, Oslo, Norway
S. Kapur*
Affiliation:
Institute of Psychiatry, Kings College, London, UK
*
*Address for correspondence: S. Kapur, M.D., Ph.D., Institute of Psychiatry, PO Box 54, De Crespigny Park, London, SE5 8AF, UK. (Email: [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

Modelpsychosissalience
Type
Commentary
Information
Psychological Medicine , Volume 39 , Issue 2 , February 2009 , pp. 197 - 198
Copyright
Copyright © 2008 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Box, GEP (1979). Robustness in the strategy of scientific model building. In Robustness in Statistics (ed. Launer, R. L. and Wilkinson, G. N.). Academic Press: New York.Google Scholar
Jensen, J, Willeit, M, Zipursky, RB, Savina, I, Smith, AJ, Menon, M, Crawley, AP, Kapur, S (2008). The formation of abnormal associations in schizophrenia: neural and behavioral evidence. Neuropsychopharmacology 33, 473–479.CrossRefGoogle ScholarPubMed
Juckel, G, Schlagenhauf, F, Koslowski, M, Filonov, D, Wustenberg, T, Villringer, A, Knutson, B, Kienast, T, Gallinat, J, Wrase, J, Heinz, A (2006 a). Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berlin) 187, 222–228.CrossRefGoogle Scholar
Juckel, G, Schlagenhauf, F, Koslowski, M, Wustenberg, T, Villringer, A, Knutson, B, Wrase, J, Heinz, A (2006 b). Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage 29, 409–416.CrossRefGoogle ScholarPubMed
Kapur, S (2003). Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry 160, 13–23.CrossRefGoogle ScholarPubMed
Murray, GK, Corlett, PR, Clark, L, Pessiglione, M, Blackwell, AD, Honey, G, Jones, PB, Bullmore, ET, Robbins, TW, Fletcher, PC (2008). Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry 13, 239, 267–276.CrossRefGoogle ScholarPubMed
Roiser, JP, Stephan, KE, den Ouden, HEM, Barnes, TRE, Friston, KJ, Joyce, EM (2008). Do patients with schizophrenia exhibit aberrant salience? Psychological Medicine. Published online: 30 June 2008. doi:10.1017/S0033291708003863.Google ScholarPubMed
Schlagenhauf, F, Juckel, G, Koslowski, M, Kahnt, T, Knutson, B, Dembler, T, Kienast, T, Gallinat, J, Wrase, J, Heinz, A (2008). Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine. Psychopharmacology (Berlin) 196, 673–684.CrossRefGoogle ScholarPubMed