Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-28T16:25:19.989Z Has data issue: false hasContentIssue false
  • English
  • Français

Role of fluphenazine decanoate in lessening the burden of chronic schizophrenics on the community

Published online by Cambridge University Press:  09 July 2009

Barbara C. Stevens
Barbara C. Stevens
Affiliation:
From the Medical Research Council Social Psychiatry Unit, Institute of Psychiatry, De Crespigny Park, London SE5
Get access Rights & Permissions [Opens in a new window]

Synopsis

This paper reports the social results of a double-blind placebo controlled trial of fluphenazine decanoate. Among patients on placebo there was a deterioration in family relationships, which was due to an increase in aggression, noisiness, talking about delusions, and socially embarrassing behaviour after withdrawal of active drug.

Type
Research Article
Information
Psychological Medicine , Volume 3 , Issue 2 , May 1973 , pp. 141 - 158
Copyright
Copyright © Cambridge University Press 1973

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Allert, M.-L. (1969). Über die Bedeutung der ambulanten Nachsorge mit Psychopharmaka. Arzneimittel-Forschung, 19, 527–528.Google Scholar
Angrist, S. S., Lefton, M., Dinitz, S., and Pasamanick, B. (1968). Women after Treatment. Appleton: New York.Google Scholar
Bartholomew, A. A. (1968). A long-acting phenothiazine as a possible agent to control deviant sexual behavior. American Journal of Psychiatry, 124, 917–923.CrossRefGoogle ScholarPubMed
Benassi, P., Bertolotti, P., and Pecorari, T. (1966). Esperienze cliniche con un derivato fenotiazinico ad azione prolungata. Rivista Sperimentale di Freniatria e Medicina Legale delle Alienazioni Mentali, 90, 51–75.Google Scholar
Bennett, D. (1967). Social therapy and drug treatment in scho/phrenia: a review. In New Aspects of the Mental Health Service. pp. 76–87. Edited by Freeman, H. and Farndale, W.. Pergamon Press: Oxford.Google Scholar
Blackwell, B., and Shepherd, M. (1968). Prophylactic lithium: another therapeutic myth? Lancet. 1, 968–971.CrossRefGoogle ScholarPubMed
Brown, G. W., Bone, M., Dalison, B., and Wing, J. K.(1966). Schizophrenia and Social Care. Maudsley Monograph No. 17. Oxford University Press: London.Google Scholar
Bucci, L., Fuchs, M., Simeon, J., and Fink, M. (1970). Depot fluphenazine in the treatment of psychosis in a community mental health clinic. Diseases of the Nervous System, 31, Sept. Suppl., 28–31.Google Scholar
Capstick, N. (1970). Long-acting drug treatment in overall psychiatric management. Diseases of the Nervous System, 31, Sept. Suppl., 15–17.Google Scholar
Crumpton, N. (1968). The role of drugs in maintaining patients in the community. In The Treatment of Mental Disorders in the Community, pp. 15–24. Edited by Daniel, G. R. and Freeman, H. L.. Baillière: London.Google Scholar
Daniel, G. R. (1968). Social and economic effects of long-acting phenothiazines. British Journal of Social Psychiatry, 2, 167–169.Google Scholar
De Alarcón, R., and Carney, M. W. P. (1969). Severe depressive mood changes following slow-release intramuscular fluphenazine injection. British Medical Journal, 3, 564–567.CrossRefGoogle ScholarPubMed
Denham, J., and Adamson, L. (1971). The contribution of fluphenazine enanthate and decanoate in the prevention of re-admission of schizophrenic patients. Acta Psychiatrica Scandinavica, 47, 420–450.CrossRefGoogle Scholar
Edwards, A. L. (1960). Experimental Design in Psychological Research. 2nd edn.Rinehart: New York.Google Scholar
Engelhardt, D. M., and Freedman, N. (1970). Maintenance drug therapy: the schizophrenic patient in the community. In Social Psychiatry. Vol. 1. pp. 256–282. Edited by Kiev, A.. Routledge: London.Google Scholar
Finney, D. J., Latscha, R., Bennett, B. M., and Hsu, P. (1963). Tables for Testing Significance in a 2 × 2 Contingency Table. Cambridge University Press: London.Google Scholar
Freeman, H., and Johnson, D. A. W. (1970). Community care. New Society, 15, 702.Google Scholar
Garcia, J. A., Madalena, J. C., Ferreira, L. R., and Gangemi, G. (1965). Experiêncies psicofarmacológitas com um no˚vo derivado fenotiazinico de açâo prolongada. Hospital (Rio), 67, 29–41.Google Scholar
Goldberg, S. C., Schooler, N. R., Davidson, E. M., and Kayce, M. M. (1966). Sex and race differences in response to drug treatment among schizophrenics. Psychopharmacologia, 9, 31–47.Google Scholar
Goldberg, S. C., Schooler, N. R., and Mattsson, N. (1967). Paranoid and withdrawal symptoms in schizophrenia: differential symptom reduction over time. Journal of Nervous and Mental Disorders, 145, 158–162.CrossRefGoogle ScholarPubMed
Gove, W. R. (1970). Societal reaction as an explanation of mental illness: an evaluation. American Sociological Review, 35, 873–884.Google Scholar
Grosser, H. H.(1970). Experience of psychiatric management of schizophrenia with fluphenazine decanoate. Diseases of the Nervous System, 31, Sept. Suppl., 32–36.Google Scholar
Heinrich, K. (1969). Zur Bedeutung des Depot–Neurolepticums Fluphenazin-decanoate für die Therapie schizophrener Psychosen. Arzneimittel-Forschung, 19, 502–503.Google Scholar
Hirsch, S., Gaind, R., Rohde, P., Stevens, B., and Wing, J. K. (1973). Out-patient maintenance treatment of chronic schizophrenics with fluphenazine decanoate injections: a double blind placebo trial. British Medical Journal, 1, 633–637.CrossRefGoogle Scholar
Hoenig, J., and Hamilton, M. W. (1969). The Desegregation of the Mentally III. Routledge: London.Google Scholar
Imlah, N. W. (1971). Recent advances in the treatment of schizophrenia. Midland Medical Review, 7, 14–22.Google Scholar
Itil, T., and Keskiner, A. (1970). Fluphenazine hydrochloride, enanthate, and decanoate in the management of chronic psychosis. Diseases of the Nervous System, 31, Sept. Suppl. 37–42.Google Scholar
John, A. L., Leite-Ribeiro, M. O., and Buckle, D. (1963). The Nurse in Mental Health Practice. Public Health Papers No. 22. World Health Organization: Geneva.Google ScholarPubMed
Kerckhoff, A. C. (1965). Nuclear and extended family relationships: a normative and behavioral analysis. In Social Structure and the Family: Generational Relations, pp. 93–112. Edited by Shanas, E. and Streib, G. F.. Prentice-Hall: Englewood Cliffs, N.J.Google Scholar
Kurland, A. A., and Richardson, J. H. (1966). A comparative study of two long acting phenothiazine preparations, fluphenazine-enanthate and fluphenazine-decanoate. Psychopharmacologia, 9, 320–327.CrossRefGoogle ScholarPubMed
Kurland, A. A., Dim, B. H., and Olsson, J. E. (1970). The effectiveness of parenteral administration of fluphenazine decanoate in the treatment of chronic schizophrenics. Diseases of the Nervous System, 31, Sept. Suppl., 18–23.Google Scholar
Lambert, P. A., and Marcou, G. (1970). Fluphenazine enanthate given to inpatients and outpatients. Diseases of the Nervous System, 31, Sept. Suppl., 63–65.Google Scholar
Leff, J. P., and Wing, J. K. (1971). Trial of maintenance therapy in schizophrenia. British Medical Journal, 3, 599–604.Google Scholar
Lehmann, H. E. (1970). The philosophy of a long-acting medication in psychiatry. Diseases of the Nervous System, 31, Sept. Suppl., 7–9.Google ScholarPubMed
Litwak, E. (1965). Extended kin relations in an industrial democratic society. In Social Structure and the Family: Generational Relations, pp. 290–323. Edited by Shanas, E. and Streib, G. F.. Prentice-Hall: Englewood Cliffs, N.J.Google Scholar
Lowther, J. (1969). The effect of fluphenazine enanthate on chronic and relapsing schizophrenia. (Abstract.) British Journal of Psychiatry, 115, 691–692.Google Scholar
Mariátegui, T., Alarcón, R., Arana, J., Azcárate, C., and Butler, A. (1966). Ensayo terapeutico con un derivado fenotiacinico de accion prolongada. El enantato de flufenacina en un grupo de esquizofrénicos cronicos. Revista de Neuro-psiquiatria, 29, 33–44.Google Scholar
Maxwell, A. E. (1961). Analysing Qualitative Data. Methuen: London.Google Scholar
Millar, J., and Daniel, G. R. (1967). A trial of fluphenazine enanthate in chronic schizophrenia. British Journal of Psychiatry, 113, 1431–1432.Google Scholar
Pfeiffer, W. M., and Gebelein, H. (1969). Zur klinischen Wirkung des Fluphenazin-decanoat bei einer deutschen and indonesischen Patientengruppe. I. Mitteilung. Arzneimittel-Forschung, 19, 500–502.Google Scholar
Pinker, R. (1971). Social Theory and Social Policy. Heinemann Educational: London.Google Scholar
Polvan, N. (1970). Fluphenazine hydrochloride and enanthate in the management of chronic psychosis. Diseases of the Nervous System, 31, Sept. Suppl., 48–49.Google Scholar
Popper, K. R. (1959). The Logic of Scientific Discovery. Hutchinson: London.Google Scholar
Renton, C. A., Affleck, J. W., Carstairs, G. M., and Forrest, A. D. (1963). A follow-up of schizophrenic patients in Edinburgh. Acta Psychiatrica Scandinavica, 39, 548–600.Google Scholar
Sanseigne, A. J., Yale, H. L., Hess, S. M., Burke, J. C., and Horovitz, Z. P. (1968). New concept of phenothiazine therapy fluphenazine enanthate and fluphenazine decanoate. Agressologie, 9, 309–313.Google ScholarPubMed
Scarpitti, F. R., Lefton, M., Dinitz, S., and Pasamanick, B. (1964). Problems in a home care study for schizophrenics. Archives of General Psychiatry, 10, 143–154.CrossRefGoogle Scholar
Shepherd, M. (1969). Some aspects of clinical trials in psychiatry In Practical Treatment in Psychiatry, pp. 145–157. Edited by Crammer, J. L.. Blackwell: Oxford.Google Scholar
Siegel, S. (1956). Nonparametric Statistics far the Behavioral Sciences. McGraw-Hill: New York.Google Scholar
Stevens, B. C. (1969a). Probability of marriage and fertility of women suffering from schizophrenia or affective disorders. Population Studies, 23, 435–454.CrossRefGoogle ScholarPubMed
Stevens, B. C. (1969b). Marriage and Fertility of Women Suffering from Schizophrenia or Affective Disorders. Maudsley Monograph No. 19. Oxford University Press: London.Google ScholarPubMed
Stevens, B. C. (1970). Frequency of separation and divorce amongst women aged 16–49 suffering from schizophrenia and affective disorders. Acta Psychiatrica Scandinavica 46, 136–150.Google Scholar
Stevens, B. C. (1972a). Dependence of schizophrenic patients on elderly relatives. Psychological Medicine, 2, 17–32.Google Scholar
Stevens, B. (1972b). The impact of fluphenazine decanoate on the family life of schizophrenics. In International Symposium on Rehabilitation in Psychiatry. Proceedings of Symposium, Belgrade, 1972, pp. 621–628. NIP ‘SELO’: Belgrade.Google Scholar
Townsend, P. (1965). The effects of family structure on the likelihood of admission to an institution in old age: the application of a general theory. In Social Structure and the Family: Generational Relations, pp. 163–187. Edited by Shanas, E. and Streib, G. F.. Prentice-Hall, Englewood Cliffs: N.J.Google Scholar
Willcox, D. R. C., Gillan, R., and Hare, E. H. (1965). Do psychiatric out-patients take other drugs? British Medical Journal, 2, 790–792.Google Scholar
Wing, J. K. (1971). Standardization of psychiatric classification. Proceedings of the Royal Society of Medicine, 64, 673–675.Google Scholar
Wing, J. K., Birley, J. L. T., Cooper, J. E., Graham, P., and Isaacs, A. D. (1967). Reliability of a procedure for measuring and classifying ‘present psychiatric state’. British Journal of Psychiatry, 113, 499–515.CrossRefGoogle ScholarPubMed
Wintrob, R. M. (1970). Long acting phenothiazines and long term psychotic patients: the role of fluphenazine enanthate in treatment. Diseases of the Nervous System, 31, Sept. Suppl., 50–62.Google Scholar