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Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study

Published online by Cambridge University Press:  24 June 2016

M. Hu ,
X. Zong ,
J. Zheng ,
J. J. Mann ,
Z. Li ,
S. P. Pantazatos ,
Y. Li ,
Y. Liao ,
Y. He  and
J. Zhou
...Show all authors
M. Hu
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
X. Zong
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China
J. Zheng
Affiliation:
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China
J. J. Mann
Affiliation:
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
Z. Li
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China
S. P. Pantazatos
Affiliation:
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry, Columbia University, New York, NY 10032, USA
Y. Li
Affiliation:
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China
Y. Liao
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA 90024,USA
Y. He
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China
J. Zhou
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China
D. Sang
Affiliation:
Department of Radiology, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, People's Republic of China
H. Zhao
Affiliation:
Department of Radiology, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, People's Republic of China
J. Tang*
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA 90024,USA
H. Chen*
Affiliation:
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China
L. Lv*
Affiliation:
Department of Psychiatry, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, People's Republic of China Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Xinxiang Medical University, Xinxiang, Henan 453002, People's Republic of China
X. Chen*
Affiliation:
Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China The China National Clinical Research Center for Mental Health Disorders, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China National Technology Institute of Psychiatry, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China
*
*Address for correspondence: X. Chen, J. Tang, H. Chen and L. Lv, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. (Email: [email protected]; [email protected]; [email protected]; [email protected])
*Address for correspondence: X. Chen, J. Tang, H. Chen and L. Lv, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. (Email: [email protected]; [email protected]; [email protected]; [email protected])
*Address for correspondence: X. Chen, J. Tang, H. Chen and L. Lv, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. (Email: [email protected]; [email protected]; [email protected]; [email protected])
*Address for correspondence: X. Chen, J. Tang, H. Chen and L. Lv, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. (Email: [email protected]; [email protected]; [email protected]; [email protected])
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Abstract

Background

It remains unclear whether the topological deficits of the white matter network documented in cross-sectional studies of chronic schizophrenia patients are due to chronic illness or to other factors such as antipsychotic treatment effects. To answer this question, we evaluated the white matter network in medication-naive first-episode schizophrenia patients (FESP) before and after a course of treatment.

Method

We performed a longitudinal diffusion tensor imaging study in 42 drug-naive FESP at baseline and then after 8 weeks of risperidone monotherapy, and compared them with 38 healthy volunteers. Graph theory was utilized to calculate the topological characteristics of brain anatomical network. Patients’ clinical state was evaluated using the Positive and Negative Syndrome Scale (PANSS) before and after treatment.

Results

Pretreatment, patients had relatively intact overall topological organizations, and deficient nodal topological properties primarily in prefrontal gyrus and limbic system components such as the bilateral anterior and posterior cingulate. Treatment with risperidone normalized topological parameters in the limbic system, and the enhancement positively correlated with the reduction in PANSS-positive symptoms. Prefrontal topological impairments persisted following treatment and negative symptoms did not improve.

Conclusions

During the early phase of antipsychotic medication treatment there are region-specific alterations in white matter topological measures. Limbic white matter topological dysfunction improves with positive symptom reduction. Prefrontal deficits and negative symptoms are unresponsive to medication intervention, and prefrontal deficits are potential trait biomarkers and targets for negative symptom treatment development.

Keywords

First-episode schizophrenialongitudinal studiesnetworksschizophreniatopologywhite matter
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 12 , September 2016 , pp. 2549 - 2560
Copyright
Copyright © Cambridge University Press 2016 

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