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Reward learning deficits in Parkinson's disease depend on depression

Published online by Cambridge University Press:  04 April 2017

M. H. M. Timmer ,
G. Sescousse ,
M. E. van der Schaaf ,
R. A. J. Esselink  and
R. Cools
M. H. M. Timmer*
Affiliation:
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands Department of Neurology and Parkinson Center Nijmegen (ParC), Radboud University Medical Center, Nijmegen, The Netherlands
G. Sescousse
Affiliation:
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands
M. E. van der Schaaf
Affiliation:
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands
R. A. J. Esselink
Affiliation:
Department of Neurology and Parkinson Center Nijmegen (ParC), Radboud University Medical Center, Nijmegen, The Netherlands
R. Cools
Affiliation:
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands
*
*Address for correspondence: M. H. M. Timmer, M.D., Department of Neurology (HP 935), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. (Email: [email protected])
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Abstract

Background

Depression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal.

Methods

We investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging in 22 non-depressed PD patients and 19 PD patients with past or present depression.

Results

PD patients with a depression (history) exhibited impaired reward v. punishment reversal learning as well as reduced reward v. punishment-related BOLD signal in the striatum (putamen) compared with non-depressed PD patients. No effects of dopaminergic medication were observed.

Conclusions

The present findings demonstrate that impairments in reversal learning from reward v. punishment and associated striatal signalling depend on the presence of (a history of) depression in PD.

Keywords

Parkinson's diseasedepressiondopaminelearningfunctional MRI
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 13 , October 2017 , pp. 2302 - 2311
Copyright
Copyright © Cambridge University Press 2017 

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