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Resilience and corpus callosum microstructure in adolescence

Published online by Cambridge University Press:  30 March 2015

A. Galinowski ,
R. Miranda ,
H. Lemaitre ,
M.-L. Paillère Martinot ,
E. Artiges ,
H. Vulser ,
R. Goodman ,
J. Penttilä ,
M. Struve  and
A. Barbot
...Show all authors
A. Galinowski*
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Paris-Sud 11, Orsay, France
R. Miranda
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Paris-Sud 11, Orsay, France
H. Lemaitre
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Paris-Sud 11, Orsay, France
M.-L. Paillère Martinot
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France Université Paris-Sud 11, Orsay, France
E. Artiges
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Paris-Sud 11, Orsay, France Psychiatry Department 91G16, Orsay Hospital, Orsay, France
H. Vulser
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Paris-Sud 11, Orsay, France
R. Goodman
Affiliation:
King's College, London Institute of Psychiatry, London, UK
J. Penttilä
Affiliation:
Psychiatry Department, University of Tampere, School of Medicine, Tampere, Finland
M. Struve
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
A. Barbot
Affiliation:
Neurospin, Saclay, France
T. Fadai
Affiliation:
Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany
L. Poustka
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
P. Conrod
Affiliation:
King's College, London Institute of Psychiatry, London, UK Department of Psychiatry, Université de Montréal, CHU Ste Justine Hospital, Montréal, QC, Canada
T. Banaschewski
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
G. J. Barker
Affiliation:
King's College, London Institute of Psychiatry, London, UK
A. Bokde
Affiliation:
Institute of Neuroscience and Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland
U. Bromberg
Affiliation:
Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany
C. Büchel
Affiliation:
Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany
H. Flor
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
J. Gallinat
Affiliation:
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité–Universitätsmedizin, Berlin, Germany
H. Garavan
Affiliation:
Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland Departments of Psychiatry and Psychology, University of Vermont, USA
A. Heinz
Affiliation:
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité–Universitätsmedizin, Berlin, Germany
B. Ittermann
Affiliation:
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany
V. Kappel
Affiliation:
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany
C. Lawrence
Affiliation:
School of Psychology, University of Nottingham, UK
E. Loth
Affiliation:
King's College, London Institute of Psychiatry, London, UK MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK
K. Mann
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
F. Nees
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
T. Paus
Affiliation:
School of Psychology, University of Nottingham, UK Rotman Research Institute, University of Toronto, Toronto, ONT, Canada Montreal Neurological Institute, McGill University, QC, Canada
Z. Pausova
Affiliation:
Department of Physiology and Nutritional Sciences, The Hospital for Sick Children, University of Toronto, Toronto, ONT, Canada
J.-B. Poline
Affiliation:
Neurospin, Saclay, France Helen Wills Neuroscience Institute, University of California, Berkeley, USA
M. Rietschel
Affiliation:
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany
T. W. Robbins
Affiliation:
Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, UK
M. Smolka
Affiliation:
Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Germany Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Germany
G. Schumann
Affiliation:
King's College, London Institute of Psychiatry, London, UK MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK
J.-L. Martinot
Affiliation:
INSERM, UMR 1000, Research unit Imaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France; AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France Université Paris-Sud 11, Orsay, France
*
*Address for correspondence: Dr A. Galinowski, INSERM UMR 1000, Research unit ‘Imaging and Psychiatry’, Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91401 Cedex Orsay, France.(Email: [email protected])
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Abstract

Background

Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents.

Method

Three groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography.

Results

Higher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups.

Conclusion

High FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.

Keywords

Adolescencecorpus callosumDAWBADTINEO-FFIresiliencetractography
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 11 , August 2015 , pp. 2285 - 2294
Copyright
Copyright © Cambridge University Press 2015 

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