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Relationships between cardiovascular and immunological changes in an experimental stress model

Published online by Cambridge University Press:  09 July 2009

R. J. Benschop ,
G. L. R. Godaert ,
R. Geenen ,
J. F. Brosschot ,
M. B. M. De Smet ,
M. Olff ,
C. J. Heijnen  and
R. E. Ballieux
R. J. Benschop*
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
G. L. R. Godaert
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
R. Geenen
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
J. F. Brosschot
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
M. B. M. De Smet
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
M. Olff
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
C. J. Heijnen
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
R. E. Ballieux
Affiliation:
Departments of Immunology and Rheumatology, University Hospital, Utrecht, Department of Clinical and Health Psychology, Utrecht University, Janus Jongbloed Research Centre, Psychoimmunophysiology Section, Utrecht, Department of Immunology, University Hospital for Children and Youth ‘Het Wilhelmina Kinderziekenhuis’, Utrecht, The Netherlands
*
1Address for correspondence: Dr Robert J. Benschop, Hannover Medical School, Department of Clinical Immunology, 30623 Hannover, Germany.
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Synopsis

To investigate the relationships between cardiovascular variables (SBP, DBP, and HR) and circulating natural killer (NK) cell numbers, 70 male volunteers were subjected to a rest condition (N = 30) or a stressful laboratory task (N = 40). At baseline, no significant relationships could be demonstrated between the number of NK cells and the cardiovascular variables. Analysis of covariance showed that the stressor induced increases in the number of NK cells, SBP, DBP, and HR. Changes in NK cell numbers were highly correlated to changes in cardiovascular variables in both the task and the no-task group. These results indicate that there is no relationship between the number of circulating NK cells and cardiovascular levels per se, but that changes in these variables, either stress-induced or under rest conditions, are regulated by a common mechanism.

Type
Original Articles
Information
Psychological Medicine , Volume 25 , Issue 2 , March 1995 , pp. 323 - 327
Copyright
Copyright © Cambridge University Press 1995

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