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The relationship between prolactin levels and clinical ratings in manic patients treated with oral and intravenous test doses of haloperidol

Published online by Cambridge University Press:  09 July 2009

J. C. Cookson ,
P. J. A. Moult ,
D. Wiles  and
G. M. Besser
J. C. Cookson*
Affiliation:
Academic Unit of Human Psychopharmacology and Department of Endocrinology, St Bartholomew's Hospital, London, Littlemore Hospital Research Unit, Oxford
P. J. A. Moult
Affiliation:
Academic Unit of Human Psychopharmacology and Department of Endocrinology, St Bartholomew's Hospital, London, Littlemore Hospital Research Unit, Oxford
D. Wiles
Affiliation:
Academic Unit of Human Psychopharmacology and Department of Endocrinology, St Bartholomew's Hospital, London, Littlemore Hospital Research Unit, Oxford
G. M. Besser
Affiliation:
Academic Unit of Human Psychopharmacology and Department of Endocrinology, St Bartholomew's Hospital, London, Littlemore Hospital Research Unit, Oxford
*
1Address for correspondence: Dr J. C. Cookson, The London Hospital (St Clement's), 2a Bow Road, London E3 4LL.
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Synopsis

Twelve manic patients were treated for 2 weeks with oral haloperidol; in 6 patients treatment commenced with intravenous haloperidol, and intravenous ‘test’ doses were given after 1, 3–5 and 14 days of oral medication. From 24 hours to 14 days baseline serum prolactin levels rose towards a plateau, as did the improvement in clinical ratings. After the first intravenous test doses of haloperidol, prolactin levels peaked at 1 hour; however, they fell to a low point at 24 hours, and no response to further test doses was seen for 3–5 days. The response tended to return at 14 days. The mechanisms underlying the changes in prolactin levels, and in clinical state, are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 2 , May 1983 , pp. 279 - 285
Copyright
Copyright © Cambridge University Press 1983

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