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Reflection impulsivity and response inhibition in first-episode psychosis: relationship to cannabis use

Published online by Cambridge University Press:  23 January 2013

V. C. Huddy ,
L. Clark ,
I. Harrison ,
M. A. Ron ,
M. Moutoussis ,
T. R. E. Barnes  and
E. M. Joyce
V. C. Huddy
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
L. Clark
Affiliation:
Department of Psychology, University of Cambridge, UK
I. Harrison
Affiliation:
Mental Health Sciences Unit, University College London, UK
M. A. Ron
Affiliation:
Institute of Neurology, University College London, UK
M. Moutoussis
Affiliation:
Institute of Neurology, University College London, UK
T. R. E. Barnes
Affiliation:
Centre for Mental Health, Imperial College, Charing Cross Campus, London, UK
E. M. Joyce*
Affiliation:
Institute of Neurology, University College London, UK
*
*Address for correspondence: Professor E. M. Joyce, Box 19, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. (Email: [email protected])
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Abstract

Background

People with psychosis demonstrate impaired response inhibition on the Stop Signal Task (SST). It is less clear if this impairment extends to reflection impulsivity, a form of impulsivity that has been linked to substance use in non-psychotic samples.

Method

We compared 49 patients with first-episode psychosis (FEP) and 30 healthy control participants on two forms of impulsivity measured using the Information Sampling Test (IST) and the SST, along with clinical and IQ assessments. We also compared those patients who used cannabis with those who had either given up or never used.

Results

Patients with FEP had significantly greater impairment in response inhibition but not in reflection impulsivity compared with healthy controls. By contrast, patients who reported current cannabis use demonstrated greater reflection impulsivity than those that had either given up or never used, whereas there were no differences in response inhibition.

Conclusions

These data suggest that abnormal reflection impulsivity is associated with substance use in psychosis but not psychosis itself; the opposite relationship may hold for response inhibition.

Keywords

Cannabisimpulsivityinhibitionpsychosisschizophreniasubstance use
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 10 , October 2013 , pp. 2097 - 2107
Copyright
Copyright © Cambridge University Press 2013 

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