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Reduced volume of parietal and frontal association areas in patients with schizophrenia characterized by passivity delusions

Published online by Cambridge University Press:  13 September 2004

P. MARUFF ,
S. J. WOOD ,
D. VELAKOULIS ,
D. J. SMITH ,
B. SOULSBY ,
J. SUCKLING ,
E. T. BULLMORE  and
C. PANTELIS
P. MARUFF
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
S. J. WOOD
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
D. VELAKOULIS
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
D. J. SMITH
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
B. SOULSBY
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
J. SUCKLING
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
E. T. BULLMORE
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
C. PANTELIS
Affiliation:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia; Brain Research Institute, Melbourne, Australia; Orygen Research Centre, University of Melbourne, Australia; Department of Psychiatry, University of Cambridge, Cambridge, UK
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Abstract

Background. In patients with schizophrenia, passivity delusions are characterized by a difficulty in determining the agency of purposive actions. Neuropsychological and functional neuroimaging data suggest that passivity delusions are associated with dysfunction of the parietal lobe association cortex.

Method. Cortical volume calculated from magnetic resonance imaging data in a group of 12 patients with schizophrenia characterized by motor passivity delusions was compared statistically with the cortical volume of 11 patients without passivity delusions.

Results. Reduced cortical volume was observed in parietal and frontal association cortices in the passivity group.

Conclusions. These data provide direct evidence for the involvement of the parietal lobe in the pathophysiology of passivity delusions in schizophrenia.

Type
Research Article
Information
Psychological Medicine , Volume 35 , Issue 6 , June 2005 , pp. 783 - 789
Copyright
© 2004 Cambridge University Press

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