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Reduced cortical call to arms differentiates psychopathy from antisocial personality disorder

Published online by Cambridge University Press:  31 July 2012

L. E. Drislane ,
U. Vaidyanathan  and
C. J. Patrick
L. E. Drislane
Affiliation:
Florida State University, Tallahassee, FL, USA
U. Vaidyanathan
Affiliation:
Florida State University, Tallahassee, FL, USA
C. J. Patrick*
Affiliation:
Florida State University, Tallahassee, FL, USA
*
*Address for correspondence: C. J. Patrick, Ph.D., 1107 West Call Street, Tallahassee, FL 32306-4301, USA. (Email: [email protected])
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Abstract

Background

Psychopathy and antisocial personality disorder (ASPD) are both characterized by impulsive, externalizing behaviors. Researchers have argued, however, that psychopathy is distinguished from ASPD by the presence of interpersonal–affective features that reflect an underlying deficit in emotional sensitivity. No study to date has tested for differential relations of these disorders with the brain's natural orienting response to sudden aversive events.

Method

Electroencephalography was used to assess cortical reactivity to abrupt noise probes presented during the viewing of pleasant, neutral and unpleasant pictures in 140 incarcerated males diagnosed using the Psychopathy Checklist – Revised and DSM-IV criteria for ASPD. The primary dependent measure was the P3 event-related potential response to the noise probes.

Results

Psychopaths showed significantly smaller amplitude of P3 response to noise probes across trials of all types compared with non-psychopaths. Follow-up analyses revealed that this overall reduction was attributable specifically to the affective–interpersonal features of psychopathy. By contrast, no group difference in general amplitude of probe P3 was evident for ASPD versus non-ASPD participants.

Conclusions

The findings demonstrate a reduced cortical orienting response to abrupt aversive stimuli in participants exhibiting features of psychopathy that are distinct from ASPD. The specificity of the observed effect fits with the idea that these distinctive features of psychopathy reflect a deficit in defensive reactivity, or mobilization of the brain's defensive system, in the context of threat cues.

Keywords

Antisocial personality disorderbrain responsedifferential diagnosisERPpsychopathy
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 4 , April 2013 , pp. 825 - 835
Copyright
Copyright © Cambridge University Press 2012

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References

APA (2012). Proposed draft revisions to DSM disorder and criteria. American Psychiatric Association: Washington, DC.Google Scholar
Bauer, LO, O'Connor, S, Hesselbrock, VM (1994). Frontal P300 decrements in antisocial personality disorder. Alcoholism: Clinical and Experimental Research 18, 1300–1305.CrossRefGoogle ScholarPubMed
Benning, SD, Patrick, CJ, Hicks, BM, Blonigen, DM, Krueger, RF (2003). Factor structure of the psychopathic personality inventory: validity and implications for clinical assessment. Psychological Assessment 15, 340–350.CrossRefGoogle ScholarPubMed
Benning, SD, Patrick, CJ, Iacono, WG (2005). Psychopathy, startle blink modulation, and electrodermal reactivity in twin men. Psychophysiology 42, 753–762.CrossRefGoogle ScholarPubMed
Blair, RJR (2001). Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. Journal of Neurology, Neurosurgery and Psychiatry 71, 727–731.CrossRefGoogle ScholarPubMed
Blair, RJR (2003). Neurobiological basis of psychopathy. British Journal of Psychiatry 182, 5–7.CrossRefGoogle ScholarPubMed
Blair, RJR, Jones, L, Clark, F, Smith, M (1997). The psychopathic individual: a lack of responsiveness to distress cues? Psychophysiology 34, 192–198.CrossRefGoogle ScholarPubMed
Blonigen, DM, Hicks, BM, Krueger, RF, Patrick, CJ, Iacono, WG (2005). Psychopathic personality traits: heritability and genetic overlap with internalizing and externalizing psychopathology. Psychological Medicine 35, 637–648.CrossRefGoogle ScholarPubMed
Bradley, MM, Lang, PJ, Cuthbert, BN (1993). Emotion, novelty, and the startle reflex: habituation in humans. Behavioral Neuroscience 107, 970–980.CrossRefGoogle ScholarPubMed
Carlson, SR, Thái, S, McLarnon, ME (2009). Visual P3 amplitude and self-reported psychopathic personality traits: frontal reduction is associated with self-centered impulsivity. Psychophysiology 46, 100–113.CrossRefGoogle ScholarPubMed
Cuthbert, BN, Schupp, HT, Bradley, M, McManis, M, Lang, PJ (1998). Probing affective pictures: attended startle and tone probes. Psychophysiology 35, 344–347.CrossRefGoogle ScholarPubMed
Czigler, I, Cox, TJ, Gyimesi, K, Horváth, J (2007). Event-related potential study to aversive auditory stimuli. Neuroscience Letters 420, 251–256.CrossRefGoogle ScholarPubMed
Decety, J, Lamm, C (2007). The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition. Neuroscientist 13, 580–593.CrossRefGoogle ScholarPubMed
Dindo, L, Fowles, D (2011). Dual temperamental risk factors for psychopathic personality: evidence from self-report and skin conductance. Journal of Personality and Social Psychology 100, 557–566.CrossRefGoogle ScholarPubMed
Drislane, LE, Lucy, MD, Yancey, JR, Vaidyanathan, U, Patrick, CJ (2011). Heritability of probe P3 amplitude and affect modulation in a community twin sample. Psychophysiology 48, S99.Google Scholar
First, MB, Spitzer, RL, Williams, JBW, Gibbon, M (1997). Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) User's Guide and Interview. American Psychiatric Press: Washington, DC.Google Scholar
Frick, PJ (1998). Conduct Disorders and Severe Antisocial Behavior. Plenum Press: New York.CrossRefGoogle Scholar
Gao, Y, Raine, A (2009). P3 event-related potential impairments in antisocial and psychopathic individuals: a meta-analysis. Biological Psychiatry 82, 199–210.Google Scholar
Graham, FK (1979). Distinguishing among orienting, defense, and startle reflexes. In The Orienting Reflex in Humans (ed. Kimmel, H. D., van Olst, E. H. and Orlebeke, J. F.), pp. 137–167. Erlbaum: Hillsdale, NJ.Google Scholar
Hare, RD (1978). Electrodermal and cardiovascular correlates of psychopathy. In Psychopathic Behavior: Approaches to Research (ed. Hare, R. D. and Schalling, D.), pp. 107–143. Wiley: Chichester, UK.Google Scholar
Hare, RD (2003). The Hare Psychopathy Checklist – Revised, 2nd edn. Multi-Health Systems: Toronto.Google Scholar
Hare, RD, Harpur, TJ, Hakstian, AR, Forth, AE, Hart, SD, Newman, JP (1990). The Revised Psychopathy Checklist: reliability and factor structure. Psychological Assessment: A Journal of Consulting and Clinical Psychology 2, 338–341.CrossRefGoogle Scholar
Hare, RD, Hart, SD, Harpur, TJ (1991). Psychopathy and the DSM-IV criteria for antisocial personality disorder. Journal of Abnormal Psychology 100, 391–398.CrossRefGoogle ScholarPubMed
Harpur, TJ, Hare, RD, Hakstian, AR (1989). Two-factor conceptualization of psychopathy: construct validity and assessment implications. Psychological Assessment: A Journal of Consulting and Clinical Psychology 1, 6–17.CrossRefGoogle Scholar
Hauk, O, Pulvermüller, F (2004). Neurophysiological distinction of action words in the fronto-central cortex. Human Brain Mapping 21, 191–201.CrossRefGoogle ScholarPubMed
Herbert, C, Kissler, J (2010). Motivational priming and processing interrupt: startle reflex modulation during shallow and deep processing of emotional words. International Journal of Psychophysiology 76, 64–71.CrossRefGoogle ScholarPubMed
Herbert, C, Kissler, J, Junghöfer, M, Peyk, P, Rockstroh, B (2006). Processing of emotional adjectives: evidence from startle EMG and ERPs. Psychophysiology 43, 197–206.CrossRefGoogle ScholarPubMed
Iacono, WG, Carlson, SR, Malone, SM, McGue, M (2002). P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys. Archives of General Psychiatry 59, 750–757.CrossRefGoogle ScholarPubMed
Keil, A, Bradley, M, Junghöfer, M, Russmann, T, Lowenthal, W, Lang, P (2007). Cross-modal attention capture by affective stimuli: evidence from event-related potentials. Cognitive, Affective and Behavioral Neuroscience 7, 18–24.CrossRefGoogle ScholarPubMed
Kiehl, KA, Bates, AT, Laurens, KR, Hare, RD, Liddle, PF (2006). Brain potentials implicate temporal lobe abnormalities in criminal psychopaths. Journal of Abnormal Psychology 115, 443–453.CrossRefGoogle ScholarPubMed
Kiehl, KA, Hare, RD, Liddle, PF, McDonald, JJ (1999). Reduced P300 responses in criminal psychopaths during a visual oddball task. Biological Psychiatry 45, 1498–1507.CrossRefGoogle ScholarPubMed
Kramer, MD, Patrick, CJ, Krueger, RF, Gasperi, M (2012). Delineating physiologic defensive reactivity in the domain of self-report: phenotypic and etiologic structure of dispositional fear. Psychological Medicine 42, 1305–1320.CrossRefGoogle ScholarPubMed
Lang, P, Bradley, M, Cuthbert, B (1999). International Affective Picture System (IAPS): Technical Manual and Affective Ratings. University of Florida, Center for Research in Psychophysiology: Gainsville.Google Scholar
Lang, PJ, Bradley, MM, Cuthbert, BN (1992). A motivational analysis of emotion: reflex-cortex connections. Psychological Science 3, 44–49.CrossRefGoogle Scholar
Lang, PJ, Bradley, MM, Cuthbert, BN (1997). Motivated attention: affect, activation, and action. In Attention and Orienting: Sensory and Motivational Processes (ed. Lang, P. J., Simons, R. F. and Balaban, M. T.), pp. 97–135. Lawrence Erlbaum Associates Publishers: Mahwah.Google Scholar
Lang, PJ, Greenwald, MK, Bradley, MM, Hamm, AO (1993). Looking at pictures: affective, facial, visceral, and behavioral reactions. Psychophysiology 30, 261–273.CrossRefGoogle ScholarPubMed
Lilienfeld, SO, Andrews, BP (1996). Development and preliminary validation of a self-report measure of psychopathic personality traits in noncriminal populations. Journal of Personality Assessment 66, 488–524.CrossRefGoogle ScholarPubMed
Lovrich, D, Novick, B, Vaughan, HG (1988). Topographic analysis of auditory event-related potentials associated with acoustic and semantic processing. Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section 71, 40–54.CrossRefGoogle ScholarPubMed
Marsh, AA, Finger, EC, Mitchell, DGV, Reid, ME, Sims, C, Kosson, DS, Towbin, KE, Leibenluft, E, Pine, DS, Blair, RJR (2008). Reduced amygdala response to fearful expressions in children and adolescents with callous–unemotional traits and disruptive behavior disorders. American Journal of Psychiatry 165, 712–720.CrossRefGoogle ScholarPubMed
Newman, JP, Schmitt, WA, Voss, WD (1997). The impact of motivationally neutral cues on psychopathic individuals: assessing the generality of the response modulation hypothesis. Journal of Abnormal Psychology 106, 563–575.CrossRefGoogle ScholarPubMed
O'Connor, S, Bauer, L, Tasman, A, Hesselbrock, V (1994). Reduced P3 amplitudes are associated with both a family history of alcoholism and antisocial personality disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 18, 1307–1321.CrossRefGoogle ScholarPubMed
Patrick, CJ (1994). Emotion and psychopathy: startling new insights. Psychophysiology 31, 319–330.CrossRefGoogle ScholarPubMed
Patrick, CJ, Bernat, EM (2009). Neurobiology of psychopathy: a two process theory. In Handbook of Neuroscience for the Behavioral Sciences, vol. 2 (ed. Berntson, G. G. and Cacioppo, J. T.), pp. 1110–1131. John Wiley & Sons Inc.: Hoboken.Google Scholar
Patrick, CJ, Bernat, EM, Malone, SM, Iacono, WG, Krueger, RF, McGue, M (2006). P300 amplitude as an indicator of externalizing in adolescent males. Psychophysiology 43, 84–92.CrossRefGoogle ScholarPubMed
Patrick, CJ, Bradley, MM, Lang, PJ (1993). Emotion in the criminal psychopath: startle reflex modulation. Journal of Abnormal Psychology 102, 82–92.CrossRefGoogle ScholarPubMed
Patrick, CJ, Fowles, DC, Krueger, RF (2009). Triarchic conceptualization of psychopathy: developmental origins of disinhibition, boldness, and meanness. Development and Psychopathology 21, 913–938.CrossRefGoogle ScholarPubMed
Patrick, CJ, Zempolich, KA, Levenston, GK (1997). Emotionality and violent behavior in psychopaths: a biosocial analysis. In Biosocial Bases of Violence (ed. Raine, A., Brennan, P. A., Farrington, D. P. and Mednick, S. A.), pp. 145–161. Plenum Press: New York.CrossRefGoogle Scholar
Raine, A (1993). The Psychopathology of Crime: Criminal Behavior as a Clinical Disorder. Academic Press: San Diego.CrossRefGoogle Scholar
Rogers, R, Duncan, JC, Lynett, E, Sewell, KW (1994). Prototypical analysis of antisocial personality disorder: DSM-IV and beyond. Law and Human Behavior 18, 471–484.CrossRefGoogle Scholar
Roth, WT, Dorato, KH, Kopell, BS (1984). Intensity and task effects on evoked physiological responses to noise bursts. Psychophysiology 21, 466–481.CrossRefGoogle ScholarPubMed
Schupp, HT, Cuthbert, BN, Bradley, MM, Birbaumer, N, Lang, PJ (1997). Probe P3 and blinks: two measures of affective startle modulation. Psychophysiology 34, 1–6.CrossRefGoogle ScholarPubMed
Schupp, HT, Cuthbert, BN, Bradley, MM, Hillman, CH, Hamm, AO, Lang, PJ (2004). Brain processes in emotional perception: motivated attention. Cognition and Emotion 18, 593–611.CrossRefGoogle Scholar
Semlitsch, HV, Anderer, P, Schuster, P, Presslich, O (1986). A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology 23, 695–703.CrossRefGoogle Scholar
Vaidyanathan, U, Hall, JR, Patrick, CJ, Bernat, EM (2011). Clarifying the role of defensive reactivity deficits in psychopathy and antisocial personality using startle reflex methodology. Journal of Abnormal Psychology 120, 253–258.CrossRefGoogle ScholarPubMed
Venables, NC, Patrick, CJ, Hohman, K, Tennenbaum, R, Bernat, EM (2010). Coherence among variants of P3 from differing tasks as indicators of the antisocial deviance factor of criminal psychopathy. Psychophysiology 47, S53–S54.Google Scholar
Viding, E, Blair, RJR, Moffitt, TE, Plomin, R (2005). Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry 46, 592–597.CrossRefGoogle ScholarPubMed
Vizueta, N, Patrick, CJ, Jiang, Y, Thomas, KM, He, S (2012). Dispositional fear, negative affectivity, and neuroimaging response to visually suppressed emotional faces. Neuroimage 59, 761–771.CrossRefGoogle ScholarPubMed