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Reduced connectivity of the auditory cortex in patients with auditory hallucinations: a resting state functional magnetic resonance imaging study

Published online by Cambridge University Press:  06 November 2009

M. Gavrilescu ,
S. Rossell ,
G. W. Stuart ,
T. L. Shea ,
H. Innes-Brown ,
K. Henshall ,
C. McKay ,
A. A. Sergejew ,
D. Copolov  and
G. F. Egan
M. Gavrilescu*
Affiliation:
Howard Florey Institute, Florey Neuroscience Institutes, Melbourne, Australia
S. Rossell
Affiliation:
Monash University, The Alfred Hospital, Prahran, Victoria, Australia
G. W. Stuart
Affiliation:
University of Melbourne, Melbourne, Australia
T. L. Shea
Affiliation:
Mental Health Research Institute, Melbourne, Australia Centre for Neuroscience, Melbourne, Australia
H. Innes-Brown
Affiliation:
Mental Health Research Institute, Melbourne, Australia
K. Henshall
Affiliation:
University of Melbourne, Melbourne, Australia
C. McKay
Affiliation:
School of Psychological Sciences, University of Manchester, UK
A. A. Sergejew
Affiliation:
Mental Health Research Institute, Melbourne, Australia
D. Copolov
Affiliation:
Mental Health Research Institute, Melbourne, Australia Monash University, Melbourne, Australia
G. F. Egan
Affiliation:
Howard Florey Institute, Florey Neuroscience Institutes, Melbourne, Australia Centre for Neuroscience, Melbourne, Australia
*
*Address for correspondence: Dr M. Gavrilescu, Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, Parkville, 3010, Victoria, Australia. (Email: [email protected])
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Abstract

Background

Previous research has reported auditory processing deficits that are specific to schizophrenia patients with a history of auditory hallucinations (AH). One explanation for these findings is that there are abnormalities in the interhemispheric connectivity of auditory cortex pathways in AH patients; as yet this explanation has not been experimentally investigated. We assessed the interhemispheric connectivity of both primary (A1) and secondary (A2) auditory cortices in n=13 AH patients, n=13 schizophrenia patients without auditory hallucinations (non-AH) and n=16 healthy controls using functional connectivity measures from functional magnetic resonance imaging (fMRI) data.

Method

Functional connectivity was estimated from resting state fMRI data using regions of interest defined for each participant based on functional activation maps in response to passive listening to words. Additionally, stimulus-induced responses were regressed out of the stimulus data and the functional connectivity was estimated for the same regions to investigate the reliability of the estimates.

Results

AH patients had significantly reduced interhemispheric connectivity in both A1 and A2 when compared with non-AH patients and healthy controls. The latter two groups did not show any differences in functional connectivity. Further, this pattern of findings was similar across the two datasets, indicating the reliability of our estimates.

Conclusions

These data have identified a trait deficit specific to AH patients. Since this deficit was characterized within both A1 and A2 it is expected to result in the disruption of multiple auditory functions, for example, the integration of basic auditory information between hemispheres (via A1) and higher-order language processing abilities (via A2).

Keywords

Functional connectivityprimary auditory cortexschizophreniasecondary auditory cortex
Type
Original Articles
Information
Psychological Medicine , Volume 40 , Issue 7 , July 2010 , pp. 1149 - 1158
Copyright
Copyright © Cambridge University Press 2009

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