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Psychological morbidity among adults with cerebral palsy and spina bifida

Published online by Cambridge University Press:  27 July 2020

Mark D. Peterson Open the ORCID record for Mark D. Peterson [Opens in a new window] ,
Paul Lin ,
Neil Kamdar ,
Elham Mahmoudi ,
Christina N. Marsack-Topolewski ,
Heidi Haapala ,
Karin Muraszko  and
Edward A. Hurvitz
Mark D. Peterson*
Affiliation:
Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA Institute for Healthcare Policy and Innovation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA
Paul Lin
Affiliation:
Institute for Healthcare Policy and Innovation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA
Neil Kamdar
Affiliation:
Institute for Healthcare Policy and Innovation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA Department of Obstetrics and Gynecology, Michigan Medicine, University of MichiganAnn Arbor, MI, USA Department of Emergency Medicine, Michigan Medicine, University of MichiganAnn Arbor, MI, USA Department of Surgery, Michigan Medicine, University of MichiganAnn Arbor, MI, USA
Elham Mahmoudi
Affiliation:
Institute for Healthcare Policy and Innovation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA Department of Family Medicine, Michigan Medicine, University of MichiganAnn Arbor, MI, USA
Christina N. Marsack-Topolewski
Affiliation:
School of Social Work, Eastern Michigan University, Ypsilanti, MI, USA
Heidi Haapala
Affiliation:
Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA
Karin Muraszko
Affiliation:
Department of Neurosurgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA
Edward A. Hurvitz
Affiliation:
Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA
*
Author for correspondence: Mark D. Peterson, E-mail: [email protected]
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Abstract

Background

Very little is known about the risk of developing psychological morbidities among adults living with cerebral palsy (CP) or spina bifida (SB). The objective of this study was to compare the incidence of and adjusted hazards for psychological morbidities among adults with and without CP or SB.

Methods

Privately insured beneficiaries were included if they had an International Classification of Diseases, Ninth revision, Clinical Modification diagnostic code for CP or SB (n = 15 302). Adults without CP or SB were also included (n = 1 935 480). Incidence estimates of common psychological morbidities were compared at 4-years of enrollment. Survival models were used to quantify unadjusted and adjusted hazard ratios for incident psychological morbidities.

Results

Adults living with CP or SB had a higher 4-year incidence of any psychological morbidity (38.8% v. 24.2%) as compared to adults without CP or SB, and differences were to a clinically meaningful extent. Fully adjusted survival models demonstrated that adults with CP or SB had a greater hazard for any psychological morbidity [hazard ratio (HR): 1.60; 95% CI 1.55–1.65], and all but one psychological disorder (alcohol-related disorders), and ranged from HR: 1.32 (1.23, 1.42) for substance disorders, to HR: 4.12 (3.24, 5.25) for impulse control disorders.

Conclusions

Adults with CP or SB have a significantly higher incidence of and risk for common psychological morbidities, as compared to adults without CP or SB. Efforts are needed to facilitate the development of improved clinical screening algorithms and early interventions to reduce the risk of disease onset/progression in these higher-risk populations.

Keywords

Anxietycerebral palsydepressiondisabilityspina bifida
Type
Original Article
Information
Psychological Medicine , Volume 51 , Issue 4 , March 2021 , pp. 694 - 701
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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References

Alriksson-Schmidt, A., Josenby, A. L., Lindquist, B., & Westbom, L. (2018). Pain and health status in adults with myelomeningocele living in Sweden. The Journal of Pediatric Rehabilitation Medicine, 11(4), 255–264. doi: 10.3233/PRM-170517.CrossRefGoogle ScholarPubMed
Atta, C. A., Fiest, K. M., Frolkis, A. D., Jette, N., Pringsheim, T., St Germaine-Smith, C., … Metcalfe, A. (2016). Global birth prevalence of spina bifida by folic acid fortification status: A systematic review and meta-analysis. American Journal of Public Health, 106(1), e24–e34. doi: 10.2105/AJPH.2015.302902.CrossRefGoogle ScholarPubMed
Bellin, M. H., Zabel, T. A., Dicianno, B. E., Levey, E., Garver, K., Linroth, R., & Braun, P. (2010). Correlates of depressive and anxiety symptoms in young adults with spina bifida. Journal of Pediatric Psychology, 35(7), 778–789. doi: 10.1093/jpepsy/jsp094.CrossRefGoogle ScholarPubMed
Benner, J. L., Hilberink, S. R., Veenis, T., Stam, H. J., van der Slot, W. M., & Roebroeck, M. E. (2017). Long-Term deterioration of perceived health and functioning in adults with cerebral palsy. Archives of Physical Medicine and Rehabilitation, 98(11), 2196–2205 e2191. doi: 10.1016/j.apmr.2017.03.013CrossRefGoogle ScholarPubMed
Benson, K., & Hartz, A. J. (2000). A comparison of observational studies and randomized, controlled trials. The New England Journal of Medicine, 342(25), 1878–1886. doi: 10.1056/NEJM200006223422506.CrossRefGoogle ScholarPubMed
Blackman, J. A., Svensson, C. I., & Marchand, S. (2018). Pathophysiology of chronic pain in cerebral palsy: Implications for pharmacological treatment and research. Developmental Medicine and Child Neurology, 60(9), 861–865. doi: 10.1111/dmcn.13930.CrossRefGoogle ScholarPubMed
Brooks, J. C., Strauss, D. J., Shavelle, R. M., Tran, L. M., Rosenbloom, L., & Wu, Y. W. (2014). Recent trends in cerebral palsy survival. Part I: Period and cohort effects. Developmental Medicine and Child Neurology, 56(11), 1059–1064. doi: 10.1111/dmcn.12520.CrossRefGoogle ScholarPubMed
Christensen, D., Van Naarden Braun, K., Doernberg, N. S., Maenner, M. J., Arneson, C. L., Durkin, M. S., … Yeargin-Allsopp, M. (2014). Prevalence of cerebral palsy, co-occurring autism spectrum disorders, and motor functioning – Autism and Developmental Disabilities Monitoring Network, USA, 2008. Developmental Medicine and Child Neurology, 56(1), 59–65. doi: 10.1111/dmcn.12268CrossRefGoogle Scholar
Dennis, M., Spiegler, B. J., & Hetherington, R. (2000). New survivors for the new millennium: Cognitive risk and reserve in adults with childhood brain insults. Brain and Cognition, 42(1), 102–105. doi: 10.1006/brcg.1999.1174.CrossRefGoogle ScholarPubMed
Dicianno, B. E., Kinback, N., Bellin, M. H., Chaikind, L., Buhari, A. M., Holmbeck, G. N., … Collins, D. M. (2015). Depressive symptoms in adults with spina bifida. Rehabilitation Psychology, 60(3), 246–253. doi: 10.1037/rep0000044.CrossRefGoogle ScholarPubMed
Doktorchik, C., Patten, S., Eastwood, C., Peng, M., Chen, G., Beck, C. A., … Quan, H. (2019). Validation of a case definition for depression in administrative data against primary chart data as a reference standard. BMC Psychiatry, 19(1), 9. doi: 10.1186/s12888-018-1990-6.CrossRefGoogle ScholarPubMed
Dosa, N. P., Foley, J. T., Eckrich, M., Woodall-Ruff, D., & Liptak, G. S. (2009). Obesity across the lifespan among persons with spina bifida. Disability and Rehabilitation, 31(11), 914–920.CrossRefGoogle ScholarPubMed
Fehlings, D. (2017). Pain in cerebral palsy: A neglected comorbidity. Developmental Medicine and Child Neurology, 59(8), 782–783. doi: 10.1111/dmcn.13477.CrossRefGoogle ScholarPubMed
Fortuna, R. J., Holub, A., Turk, M. A., Meccarello, J., & Davidson, P. W. (2018). Health conditions, functional status and health care utilization in adults with cerebral palsy. Family Practice, 35(6), 661–670. doi: 10.1093/fampra/cmy027.CrossRefGoogle ScholarPubMed
Fox, M. A., Ayyangar, R., Parten, R., Haapala, H. J., Schilling, S. G., & Kalpakjian, C. Z. (2019). Self-report of pain in young people and adults with spastic cerebral palsy: Interrater reliability of the revised Face, Legs, Activity, Cry, and Consolability (r-FLACC) scale ratings. Developmental Medicine and Child Neurology, 61(1), 69–74. doi: 10.1111/dmcn.13980.CrossRefGoogle ScholarPubMed
Goesling, J., Lin, L. A., & Clauw, D. J. (2018). Psychiatry and pain management: At the intersection of chronic pain and mental health. Current Psychiatry Reports, 20(2), 12. doi: 10.1007/s11920-018-0872-4.CrossRefGoogle ScholarPubMed
Kerr, E. A., McGlynn, E. A., Van Vorst, K. A., & Wickstrom, S. L. (2000). Measuring antidepressant prescribing practice in a health care system using administrative data: Implications for quality measurement and improvement. The Joint Commission Journal on Quality Improvement, 26(4), 203–216.CrossRefGoogle Scholar
Lampe, R., Grassl, S., Mitternacht, J., Gerdesmeyer, L., & Gradinger, R. (2006). MRT-measurements of muscle volumes of the lower extremities of youths with spastic hemiplegia caused by cerebral palsy. Brain & Development, 28(8), 500–506. doi: 10.1016/j.braindev.2006.02.009.CrossRefGoogle ScholarPubMed
Leslie, W. D., Lix, L. M., & Yogendran, M. S. (2011). Validation of a case definition for osteoporosis disease surveillance. Osteoporosis International, 22(1), 37–46. doi: 10.1007/s00198-010-1225-2.CrossRefGoogle ScholarPubMed
Lidal, I. B., Lundberg Larsen, K., & Hoff, M. (2019). 50 Years and older – born with spina bifida: Participation, health issues and physical function. Disability and Rehabilitation, 1–10. doi: 10.1080/09638288.2019.1621953Google ScholarPubMed
Maenner, M. J., Blumberg, S. J., Kogan, M. D., Christensen, D., Yeargin-Allsopp, M., & Schieve, L. A. (2016). Prevalence of cerebral palsy and intellectual disability among children identified in two US National Surveys, 2011–2013. Annals of Epidemiology, 26(3), 222–226. doi: 10.1016/j.annepidem.2016.01.001CrossRefGoogle Scholar
Marreiros, H., Monteiro, L., Loff, C., & Calado, E. (2010). Fractures in children and adolescents with spina bifida: The experience of a Portuguese tertiary-care hospital. Developmental Medicine and Child Neurology, 52(8), 754–759. doi: 10.1111/j.1469-8749.2010.03658.x.CrossRefGoogle ScholarPubMed
Moreau, N. G., Li, L., Geaghan, J. P., & Damiano, D. L. (2008). Fatigue resistance during a voluntary performance task is associated with lower levels of mobility in cerebral palsy. Archives of Physical Medicine and Rehabilitation, 89(10), 2011–2016. doi: 10.1016/j.apmr.2008.03.012.CrossRefGoogle ScholarPubMed
Morley, C. P., Struwe, S., Pratte, M. A., Clayton, G. H., Wilson, P. E., Dicianno, B. E., … Ma, T (2020). Survey of US adults with spina bifida. Disability and Health Journal, 13(2), 1–8. doi: https://doi.org/10.1016/j.dhjo.2019.100833.CrossRefGoogle ScholarPubMed
Mukherjee, S., & Pasulka, J. (2017). Care for adults with spina bifida: Current state and future directions. Topics in Spinal Cord Injury Rehabilitation, 23(2), 155–167. doi: 10.1310/sci2302-155.CrossRefGoogle ScholarPubMed
Noyes, K., Liu, H., Lyness, J. M., & Friedman, B. (2011). Medicare beneficiaries with depression: Comparing diagnoses in claims data with the results of screening. Psychiatric Services, 62(10), 1159–1166. doi: 10.1176/ps.62.10.pss6210_1159.CrossRefGoogle ScholarPubMed
Paneth, N., Hong, T., & Korzeniewski, S. (2006). The descriptive epidemiology of cerebral palsy. Clinics in Perinatology, 33(2), 251–267. doi: 10.1016/j.clp.2006.03.011.CrossRefGoogle ScholarPubMed
Peterson, M. D., Gordon, P. M., & Hurvitz, E. A. (2013). Chronic disease risk among adults with cerebral palsy: The role of premature sarcopoenia, obesity and sedentary behaviour. Obesity Reviews, 14(2), 171–182. doi: 10.1111/j.1467-789X.2012.01052.x.CrossRefGoogle ScholarPubMed
Peterson, M. D., Gordon, P. M., Hurvitz, E. A., & Burant, C. F. (2012). Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy. American Journal of Physiology. Endocrinology and Metabolism, 303(9), E1085–E1093. doi: 10.1152/ajpendo.00338.2012.CrossRefGoogle ScholarPubMed
Peterson, M. D., Zhang, P., Haapala, H. J., Wang, S. C., & Hurvitz, E. A. (2015). Greater adipose tissue distribution and diminished spinal musculoskeletal density in adults with cerebral palsy. Archives of Physical Medicine and Rehabilitation, 96(10), 1828–1833. doi: 10.1016/j.apmr.2015.06.007.CrossRefGoogle ScholarPubMed
Polfuss, M., Bandini, L. G., & Sawin, K. J. (2017). Obesity prevention for individuals with spina bifida. Current Obesity Reports, 6(2), 116–126. doi: 10.1007/s13679-017-0254-y.CrossRefGoogle ScholarPubMed
Reeves, S., Garcia, E., Kleyn, M., Housey, M., Stottlemyer, R., Lyon-Callo, S., & Dombkowski, K. J. (2014). Identifying sickle cell disease cases using administrative claims. Academic Pediatrics, 14(Suppl 5), S61–S67. doi:10.1016/j.acap.2014.02.008.CrossRefGoogle ScholarPubMed
Smith, K. J., Peterson, M. D., O'Connell, N. E., Victor, C., Liverani, S., Anokye, N., & Ryan, J. M. (2018). Risk of depression and anxiety in adults with cerebral palsy. JAMA Neurology, 76(3), 294–300. doi: 10.1001/jamaneurol.2018.4147.CrossRefGoogle Scholar
Trinh, A., Wong, P., Sakthivel, A., Fahey, M. C., Hennel, S., Brown, J., … Milat, F. (2017). Fat-bone interactions in adults with spina bifida. Journal of the Endocrine Society, 1(10), 1301–1311. doi: 10.1210/js.2017-00258.CrossRefGoogle ScholarPubMed
Tsang, A., Von Korff, M., Lee, S., Alonso, J., Karam, E., Angermeyer, M. C., … Watanabe, M. (2008). Common chronic pain conditions in developed and developing countries: Gender and age differences and comorbidity with depression-anxiety disorders. Journal of Pain, 9(10), 883–891. doi: 10.1016/j.jpain.2008.05.005.CrossRefGoogle ScholarPubMed
van der Slot, W. M. A., Benner, J. L., Brunton, L., Engel, J. M., Gallien, P., Hilberink, S. R., … Roebroeck, M. E. (2020). Pain in adults with cerebral palsy: A systematic review and meta-analysis of individual participant data. Annals of Physical and Rehabilitation Medicine. doi: 10.1016/j.rehab.2019.12.011.CrossRefGoogle ScholarPubMed
van Gorp, M., Dallmeijer, A., van Wely, L., de Groot, V., Terwee, C., Flens, G., … Roebroeck, M. (2019). Pain, fatigue, depressive symptoms and sleep disturbance in young adults with cerebral palsy. Disability and Rehabilitation, In Press. doi.org/10.1080/09638288.2019.1694998.CrossRefGoogle Scholar
Verschuren, O., Smorenburg, A. R. P., Luiking, Y., Bell, K., Barber, L., & Peterson, M. D. (2018). Determinants of muscle preservation in individuals with cerebral palsy across the lifespan: A narrative review of the literature. Journal of Cachexia, Sarcopenia and Muscle, 9(3), 453–464. doi: 10.1002/jcsm.12287.CrossRefGoogle ScholarPubMed
Wagner, R., Linroth, R., Gangl, C., Mitchell, N., Hall, M., Cady, R., & Christenson, M. (2015). Perception of secondary conditions in adults with spina bifida and impact on daily life. Disability and Health Journal, 8(4), 492–498. doi: 10.1016/j.dhjo.2015.03.012.CrossRefGoogle ScholarPubMed
Ware, A. L., Kulesz, P. A., Juranek, J., Cirino, P. T., & Fletcher, J. M. (2017). Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele. Neuropsychology, 31(4), 411–423. doi: 10.1037/neu0000350.CrossRefGoogle ScholarPubMed
Whitney, D. G., Alford, A. I., Devlin, M. J., Caird, M. S., Hurvitz, E. A., & Peterson, M. D. (2019b). Adults with cerebral palsy have higher prevalence of fracture compared with adults without cerebral palsy independent of osteoporosis and cardiometabolic diseases. The Journal of Bone and Mineral Research, 34(7), 1240–1247. doi: 10.1002/jbmr.3694CrossRefGoogle Scholar
Whitney, D. G., Hurvitz, E. A., Devlin, M. J., Caird, M. S., French, Z. P., Ellenberg, E. C., & Peterson, M. D. (2018). Age trajectories of musculoskeletal morbidities in adults with cerebral palsy. Bone, 114, 285–291. doi: 10.1016/j.bone.2018.07.002.CrossRefGoogle ScholarPubMed
Whitney, D., Warschausky, S., Ng, S., Hurvitz, E., Kamdar, N., & Peterson, M. (2019a). Prevalence of mental health disorders among adults with cerebral palsy a cross-sectional analysis. Annals of Internal Medicine, 171(5), 328–333. doi: 10.7326/M18-3420.CrossRefGoogle Scholar
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