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Profiles of visuospatial memory dysfunction in opioid-exposed and dependent populations

Published online by Cambridge University Press:  20 November 2018

A. Baldacchino ,
S. Tolomeo ,
D.J. Balfour  and
K Matthews
A. Baldacchino*
Affiliation:
Division of Population and Behavioural Science, School of Medicine, St Andrews University, St Andrews, Fife, UK
S. Tolomeo
Affiliation:
School of Medicine (Neuroscience), Ninewells Hospital & Medical School, University of Dundee, Dundee, Tayside, UK
D.J. Balfour
Affiliation:
School of Medicine (Neuroscience), Ninewells Hospital & Medical School, University of Dundee, Dundee, Tayside, UK
K Matthews
Affiliation:
School of Medicine (Neuroscience), Ninewells Hospital & Medical School, University of Dundee, Dundee, Tayside, UK
*
Author for correspondence: A. Baldacchino, E-mail: [email protected]
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Abstract

Background

Chronic opioid exposure is common world-wide, but behavioural performance remains under-investigated. This study aimed to investigate visuospatial memory performance in opioid-exposed and dependent clinical populations and its associations with measures of intelligence and cognitive impulsivity.

Methods

We recruited 109 participants: (i) patients with a history of opioid dependence due to chronic heroin use (n = 24), (ii) heroin users stabilised on methadone maintenance treatment (n = 29), (iii) participants with a history of chronic pain and prescribed tramadol and codeine (n = 28) and (iv) healthy controls (n = 28). The neuropsychological tasks from the Cambridge Neuropsychological Test Automated Battery included the Delayed Matching to Sample (DMS), Pattern Recognition Memory, Spatial Recognition Memory, Paired Associate Learning, Spatial Span Task, Spatial Working Memory and Cambridge Gambling Task. Pre-morbid general intelligence was assessed using the National Adult Reading Test.

Results

As hypothesised, this study identified the differential effects of chronic heroin and methadone exposures on neuropsychological measures of visuospatial memory (p < 0.01) that were independent of injecting behaviour and dependence status. The study also identified an improvement in DMS performance (specifically at longer delays) when the methadone group was compared with the heroin group and also when the heroin group was stabilised onto methadone. Results identified differential effects of chronic heroin and methadone exposures on various neuropsychological measures of visuospatial memory independently from addiction severity measures, such as injecting behaviour and dependence status.

Keywords

Codeinecognitionheroinmethadoneopioidstramadolvisuospatial memory
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 7 , May 2019 , pp. 1174 - 1184
Copyright
Copyright © Cambridge University Press 2018 

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