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Prevalence and determinants of cognitive impairment in the euthymic phase of bipolar disorders: results from the FACE-BD cohort

Published online by Cambridge University Press:  08 May 2018

Paul Roux Open the ORCID record for Paul Roux [Opens in a new window] ,
Bruno Etain ,
Anne-Sophie Cannavo ,
Valérie Aubin ,
Bruno Aouizerate ,
Jean-Michel Azorin ,
Frank Bellivier ,
Raoul Belzeaux ,
Thierry Bougerol  and
Iréna Cussac
...Show all authors
Paul Roux*
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France
Bruno Etain
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences, Paris, France Université Paris Diderot, UMR-S 1144, Paris, France Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Affective Disorders, London, UK
Anne-Sophie Cannavo
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France
Valérie Aubin
Affiliation:
Fondation Fondamental, Créteil, France Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France
Bruno Aouizerate
Affiliation:
Fondation Fondamental, Créteil, France Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France
Jean-Michel Azorin
Affiliation:
Fondation Fondamental, Créteil, France AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, 13274 Marseille, France
Frank Bellivier
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences, Paris, France Université Paris Diderot, UMR-S 1144, Paris, France
Raoul Belzeaux
Affiliation:
Fondation Fondamental, Créteil, France AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, 13274 Marseille, France
Thierry Bougerol
Affiliation:
Fondation Fondamental, Créteil, France University Grenoble Alpes, CS 40700, 38058 Grenoble Cedex 9, France CHU de Grenoble et des Alpes, CS10217, F-38043 Grenoble, France Grenoble Institut des Neurosciences (GIN) Inserm U 836, Chemin Fortuné Ferrini, 38706 La Tronche, France
Iréna Cussac
Affiliation:
Fondation Fondamental, Créteil, France Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, BP489, 98012 Monaco, France
Philippe Courtet
Affiliation:
Fondation Fondamental, Créteil, France Department of Emergency Psychiatry & Post Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France INSERM U1061, Montpellier, France
Jean-Pierre Kahn
Affiliation:
Fondation Fondamental, Créteil, France Pôle de Psychiatrie et Psychologie Clinique – Centre Psychothérapique de Nancy, 54520 Laxou, France Université de Lorraine, Nancy, France
Marion Leboyer
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil 94000, France Université Paris Est, Faculté de Médecine, Créteil 94000, France Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France
Katia M'Bailara
Affiliation:
Fondation Fondamental, Créteil, France Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France Laboratoire de Psychologie, EA4139, Université de Bordeaux, France
Marion Perrin Payet
Affiliation:
Pôle de Psychiatrie et Psychologie Clinique – Centre Psychothérapique de Nancy, 54520 Laxou, France Université de Lorraine, Nancy, France
Emilie Olié
Affiliation:
Fondation Fondamental, Créteil, France Department of Emergency Psychiatry & Post Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France INSERM U1061, Montpellier, France
Chantal Henry
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil 94000, France Université Paris Est, Faculté de Médecine, Créteil 94000, France Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France Institut Pasteur, Unité Perception et Mémoire, F-75015 Paris, France
Christine Passerieux
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France
the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences, Paris, France Université Paris Diderot, UMR-S 1144, Paris, France Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Affective Disorders, London, UK Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, 13274 Marseille, France University Grenoble Alpes, CS 40700, 38058 Grenoble Cedex 9, France CHU de Grenoble et des Alpes, CS10217, F-38043 Grenoble, France Grenoble Institut des Neurosciences (GIN) Inserm U 836, Chemin Fortuné Ferrini, 38706 La Tronche, France Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, BP489, 98012 Monaco, France Department of Emergency Psychiatry & Post Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France INSERM U1061, Montpellier, France Pôle de Psychiatrie et Psychologie Clinique – Centre Psychothérapique de Nancy, 54520 Laxou, France Université de Lorraine, Nancy, France AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil 94000, France Université Paris Est, Faculté de Médecine, Créteil 94000, France Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France Laboratoire de Psychologie, EA4139, Université de Bordeaux, France Institut Pasteur, Unité Perception et Mémoire, F-75015 Paris, France
*
Author for correspondence: Paul Roux, E-mail: [email protected]
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Abstract

Background

Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive impairment, based on psychometric properties, to estimate the prevalence of neuropsychological deficits in euthymic BD, and identify risk factors for cognitive deficits using a multivariate approach.

Methods

We investigated neuropsychological performance in 476 euthymic patients with BD recruited via the French network of BD expert centres. We used a battery of tests, assessing five domains of cognition. Five criteria for the identification of neuropsychological impairment were tested based on their convergent and concurrent validity. Uni- and multivariate logistic regressions between cognitive impairment and several clinical and demographic variables were performed to identify risk factors for neuropsychological impairment in BD.

Results

One cut-off had satisfactory psychometric properties and yielded a prevalence of 12.4% for cognitive deficits in euthymic BD. Antipsychotics use were associated with the presence of a cognitive deficit.

Conclusions

This is the first study to validate a criterion for clinically significant cognitive impairment in BD. We report a lower prevalence of cognitive impairment than previous studies, which may have overestimated its prevalence. Patients with euthymic BD and cognitive impairment may benefit from cognitive remediation.

Keywords

Antipsychoticattentionbipolar disordercognitioneuthymicexecutivememorypsychometricremediationsocial functioning
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 3 , February 2019 , pp. 519 - 527
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

*

List of FondaMental Advanced Center of Expertise (FACE-BD): FACE-BD Clinical Coordinating Center (Fondation FondaMental); B. Etain, C. Henry, E. Olié, and M. Leboyer; FACE-BD Data Coordinating Center (Fondation FondaMental); V. Barteau, O. Godin, H. Laouamri, and Karmene Souryis; FACE-BD Clinical Sites and Principal Collaborators in France;AP-HP, DHU PePSY, Pôle de Psychiatrie et d'Addictologie des Hôpitaux Universitaires H Mondor, Créteil; S. Hotier, A. Pelletier, and A. Raust; AP-HP, GH Saint-Louis–Lariboisière–Fernand Widal, Pôle Neurosciences, Paris; F. Bellivier, M. Carminati, B. Etain, and P. Seguin; Hôpital C. Perrens, Centre Expert Trouble Bipolaire, Service de Psychiatrie Adulte, Pôle 3-4-7, Bordeaux; B. Antoniol, A. Desage, S. Gard, A. Jutant, K. Mbailara, I. Minois, and L. Zanouy; Département d'Urgence et Post Urgence Psychiatrique, CHRU Montpellier, Montpellier; S. Bonnet, F. Coppola, P. Courtet, D. Ducasse, M. Gachet, L. Matos, F. Molière, B. Noisette, E. Olié and G. Tarquini; Département de Psychiatrie, Hôpital Sainte Marguerite, Marseille; J. M. Azorin, R. Belzeaux, N. Corréard, J. L. Consoloni, F. Groppi, L. Lescalier. J. Montant and N. Viglianese; Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy; R. Cohen, J.P. Kahn, P. Kieffer, and O. Wajsbrot-Elgrabli; Clinique Universitaire de Psychiatrie, CHU de Grenoble et des Alpes, Grenoble; T. Bougerol, B. Fredembach, S. Garçon, P. Grignon, A. Perrin, and M. Polosan; Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie d'adultes, Le Chesnay; A.M. Galliot, I. Grévin, A.S. Cannavo, N. Kayser, C. Passerieux, and P. Roux; Service de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco; V. Aubin, I. Cussac, M.A Dupont, J. Loftus, and I. Medecin.

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