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Pre-morbid asociality in neuroleptic-resistant and neuroleptic-responsive schizophrenia

Published online by Cambridge University Press:  09 July 2009

R. L. Findling ,
K. Jayathilake  and
H. Y. Meltzer
R. L. Findling
Affiliation:
Department of Psychiatry, Laboratory of Biological Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
K. Jayathilake
Affiliation:
Department of Psychiatry, Laboratory of Biological Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
H. Y. Meltzer*
Affiliation:
Department of Psychiatry, Laboratory of Biological Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
*
1Address for correspondence: Professor Herbert Y. Meltzer Department of PsychiatryUniversity Hospitals of ClevelandHanna PavilionRoom B-6811100 Euclid AvenueClevelandOH 44106–5078USA.
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Synopsis

The purpose of this study was to evaluate whether childhood and adolescent premorbid asociality differed in neuroleptic-responsive and neuroleptic-resistant schizophrenia. Premorbid asociality was assessed with the Pre-morbid Asociality Adjustment Scale in 411 patients meeting DSM-III-R criteria for chronic schizophrenia or schizoaffective disorder categorized as being either neuroleptic-responsive or neuroleptic-resistant. Patterns of childhood and adolescent asociality were found to be different in neuroleptic-resistant and neuroleptic-responsive patients. Pre-morbid asociality during the pre-adult years was not consistently worse in patients with poor response to neuroleptic treatment. Greater impairment in late adolescent psychosexual functioning was predictive of poor outcome with regard to neuroleptic treatment.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 5 , September 1996 , pp. 1033 - 1041
Copyright
Copyright © Cambridge University Press 1996

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