Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-04T21:59:02.821Z Has data issue: false hasContentIssue false
  • English
  • Français

Prediction of clinical course of bipolar manic depressive illness treated with lithium

Published online by Cambridge University Press:  09 July 2009

B. B. Johnston ,
G. J. Naylor ,
E. G. Dick ,
S. E. Hopwood  and
D. A. T. Dick
B. B. Johnston*
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
G. J. Naylor
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
E. G. Dick
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
S. E. Hopwood
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
D. A. T. Dick
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
*
1Address for correspondence: Dr B. B. Johnston, Consultant Psychiatrist, Stratheden Hospital, Cupar, Fife.
Get access Rights & Permissions [Opens in a new window]

Synopsis

A group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na–K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na–K ATPase activity.

Type
Research Article
Information
Psychological Medicine , Volume 10 , Issue 2 , May 1980 , pp. 329 - 334
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bucht, G. & Wahlin, A. (1978). Impairment of renal concentrating capacity by lithium. Lancet i, 778–779.CrossRefGoogle Scholar
Burrows, G. D., Davies, B. & Kincaid-Smith, P. (1978). Unique tubular lesion after lithium. Lancet i, 1310.CrossRefGoogle Scholar
Carman, J. S., Post, R. M., Teplitz, T. A. & Goodwin, F. K. (1974). Divalent cations in predicting antidepressant response to lithium. Lancet ii, 1454.CrossRefGoogle Scholar
Frazer, A., Mendels, J., Brunswick, D., London, J., Pring, M., Ramsey, T. A. & Rybakowski, J. (1978). Erythrocyte concentrations of the lithium ion; clinical correlates and mechanisms of action. American Journal of Psychiatry 135, 1065–1069.Google ScholarPubMed
Glen, A. I. M. (1978). Lithium regulation of membrane ATPases. In Lithium in Medical Practice (ed. Johnson, F. N. and Johnson, S.), p. 186. MTP Press: Lancaster.Google Scholar
Hestbech, J., Hansen, H. E., Amdisen, A. & Olsen, S. (1977). Chronic renal lesions following long-term treatment with lithium. Kidney International 12, 205–213.CrossRefGoogle ScholarPubMed
Johnston, B. B., Dick, E. G., Naylor, G. J. & Dick, D. A. T. (1979). Lithium side effects in a routine lithium clinic. British Journal of Psychiatry 134, 482–487.CrossRefGoogle Scholar
Lee, C. R., Hill, S. E., Dimitrakoudi, M., Jenner, F. A. & Pollett, R. J. (1975). The relationship of plasma to erythrocyte lithium levels in patients taking lithium carbonate. British Journal of Psychiatry 127, 596–598.CrossRefGoogle ScholarPubMed
Mendels, J. & Frazer, A. (1973). Intracellular lithium concentration and clinical response: towards a membrane theory of depression. Journal of Psychiatric Research 10, 9–18.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T., Dick, E. G. & Moody, J. P. (1974). Lithium therapy and erythrocyte membrane cation carrier. Psychopharmacologia (Berlin) 37, 81–86.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T. & Dick, E. G. (1976). Erythrocyte membrane cation carrier, relapse rate of manic depressive illness and response to lithium. Psychological Medicine 6, 257–263.CrossRefGoogle ScholarPubMed
Perrild, H., Madsen, S. N. & Hansen, J. E. M. (1978). Irreversible myxoedema after lithium carbonate. British Medical Journal i, 1108–1109.CrossRefGoogle Scholar
Ratey, J. J. & Mallinger, A. G. (1977). The relationship between extra and intracellular lithium concentration in human red blood cells: an in vitro. study. British Journal of Psychiatry 131, 59–62.CrossRefGoogle ScholarPubMed
Serry, M. (1969). Lithium retention and response. Lancet. i, 1267–1268.CrossRefGoogle Scholar
Stokes, J. W., Mendels, J., Secunda, S. K. & Dyson, W. L. (1972). Lithium excretion and therapeutic response. Journal of Nervous and Mental Disease 154, 43–48.CrossRefGoogle ScholarPubMed