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A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence

Published online by Cambridge University Press:  21 April 2010

A. C. Edwards ,
H. H. Maes ,
N. L. Pedersen  and
K. S. Kendler
A. C. Edwards*
Affiliation:
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
H. H. Maes
Affiliation:
Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
N. L. Pedersen
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
K. S. Kendler
Affiliation:
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
*
*Address for correspondence: A. C. Edwards, Ph.D., Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, PO Box 980126, Richmond, VA23298-0126, USA. (Email: [email protected])
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Abstract

Background

Numerous epidemiological studies have reported a positive association between major depression (MD) and regular tobacco use (RU) or nicotine dependence (ND). However, few have used a genetically informative design to assess whether these traits share a common genetic and/or environmental liability.

Method

We assessed MD, RU and ND in same-sex twins from the population-based Swedish Twin Registry. In males, we examined both cigarette use and snus (smokeless tobacco) use. We used structural equation modeling to examine the relationship between MD, RU, and ND given RU.

Results

The results suggest modest correlations between MD and RU, and between MD and ND. In males, the liability shared between MD and RU is solely genetic for both cigarettes and snus, while MD and ND share both genetic and unique environmental influences. The continuation to ND given RU differed considerably between cigarette and snus users. In females, both MD–RU and MD–ND relationships are partially attributable to genetic and unique environmental correlations.

Conclusions

The relationship among MD, RU and ND is at least partially attributable to shared genetic and environmental risk factors. The genetic and environmental correlations between traits are modest. The nature of the shared liability differs by sex, and in males, by the type of tobacco product used. Differences between previous reports and results presented in the current study are suggestive of population differences in how MD and tobacco use inter-relate.

Keywords

Genetic riskshared liabilitytwin modeling
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 2 , February 2011 , pp. 395 - 405
Copyright
Copyright © Cambridge University Press 2010

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References

Akaike, H (1987). Factor analysis and AIC. Psychometrika 52, 317–332.CrossRefGoogle Scholar
Balfour, DJ, Ridley, DL (2000). The effects of nicotine on neural pathways implicated in depression: a factor in nicotine addiction? Pharmacology Biochemistry and Behavior 66, 79–85.CrossRefGoogle ScholarPubMed
Breslau, N, Johnson, EO (2000). Predicting smoking cessation and major depression in nicotine-dependent smokers. American Journal of Public Health 90, 1122–1127.Google ScholarPubMed
Breslau, N, Kilbey, M, Andreski, P (1991). Nicotine dependence, major depression, and anxiety in young adults. Archives of General Psychiatry 48, 1069–1074.CrossRefGoogle ScholarPubMed
Ding, J, Nieto, FJ, Beauchamp, NJ, Longstreth, WT Jr, Manolio, TA, Hetmanski, JB, Fried, LP (2003). A prospective analysis of risk factors for white matter disease in the brain stem: the Cardiovascular Health Study. Neuroepidemiology 22, 275–282.CrossRefGoogle ScholarPubMed
Fagerstrom, K (2005). The nicotine market: an attempt to estimate the nicotine intake from various sources and the total nicotine consumption in some countries. Nicotine and Tobacco Research 7, 343–350.CrossRefGoogle ScholarPubMed
Fu, Q, Heath, AC, Bucholz, KK, Nelson, E, Goldberg, J, Lyons, MJ, True, WR, Jacob, T, Tsuang, MT, Eisen, SA (2002). Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men. Archives of General Psychiatry 59, 1125–1132.CrossRefGoogle ScholarPubMed
Heatherton, TF, Kozlowski, LT, Frecker, RC, Fagerstrom, KO (1991). The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction 86, 1119–1127.CrossRefGoogle ScholarPubMed
Hughes, JR, Oliveto, AH, Riggs, R, Kenny, M, Liguori, A, Pillitteri, JL, MacLaughlin, MA (2004). Concordance of different measures of nicotine dependence: two pilot studies. Addictive Behaviors 29, 1527–1539.CrossRefGoogle ScholarPubMed
Kandel, D, Schaffran, C, Griesler, P, Samuolis, J, Davies, M, Galanti, R (2005). On the measurement of nicotine dependence in adolescence: comparisons of the mFTQ and a DSM-IV-based scale. Journal of Pediatric Psychology 30, 319–332.CrossRefGoogle Scholar
Kendler, KS (1983). Overview: a current perspective on twin studies of schizophrenia. American Journal of Psychiatry 140, 1413–1425.Google ScholarPubMed
Kendler, KS, Aggen, SH, Prescott, CA, Jacobson, KC, Neale, MC (2004). Level of family dysfunction and genetic influences on smoking in women. Psychological Medicine 34, 1263–1269.CrossRefGoogle ScholarPubMed
Kendler, KS, Gatz, M, Gardner, CO, Pedersen, NL (2006). A Swedish national twin study of lifetime major depression. American Journal of Psychiatry 163, 109–114.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, MacLean, CJ, Heath, AC, Eaves, LJ, Kessler, RC (1993). Smoking and major depression. A causal analysis. Archives of General Psychiatry 50, 36–43.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, Sullivan, P, Corey, LA, Gardner, CO, Prescott, CA (1999). A population-based twin study in women of smoking initiation and nicotine dependence. Psychological Medicine 29, 299–308.CrossRefGoogle ScholarPubMed
Kendler, KS, Thornton, LM, Pedersen, NL (2000). Tobacco consumption in Swedish twins reared apart and reared together. Archives of General Psychiatry 57, 886–892.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, PA, Borges, G, Castilla-Puentes, RC, Glantz, MD, Jaeger, SA, Merikangas, KR, Nock, MK, Russo, LJ, Stang, PE (2007). Smoking and suicidal behaviors in the National Comorbidity Survey: Replication. Journal of Nervous and Mental Disease 195, 369–377.CrossRefGoogle ScholarPubMed
Klungsoyr, O, Nygard, JF, Sorensen, T, Sandanger, I (2006). Cigarette smoking and incidence of first depressive episode: an 11-year, population-based follow-up study. American Journal of Epidemiology 163, 421–432.CrossRefGoogle ScholarPubMed
Korhonen, T, Broms, U, Varjonen, J, Romanov, K, Koskenvuo, M, Kinnunen, T, Kaprio, J (2007). Smoking behaviour as a predictor of depression among Finnish men and women: a prospective cohort study of adult twins. Psychological Medicine 37, 705–715.CrossRefGoogle ScholarPubMed
Lichtenstein, P, De Faire, U, Floderus, B, Svartengren, M, Svedberg, P, Pedersen, NL (2002). The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine 252, 184–205.CrossRefGoogle ScholarPubMed
Lyons, M, Hitsman, B, Xian, H, Panizzon, MS, Jerskey, BA, Santangelo, S, Grant, MD, Rende, R, Eisen, S, Eaves, L, Tsuang, MT (2008). A twin study of smoking, nicotine dependence, and major depression in men. Nicotine and Tobacco Research 10, 97–108.CrossRefGoogle ScholarPubMed
Maes, HH, Sullivan, PF, Bulik, CM, Neale, MC, Prescott, CA, Eaves, LJ, Kendler, KS (2004). A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence. Psychological Medicine 34, 1251–1261.CrossRefGoogle ScholarPubMed
Malone, KM, Waternaux, C, Haas, GL, Cooper, TB, Li, S, Mann, JJ (2003). Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders. American Journal of Psychiatry 160, 773–779.CrossRefGoogle ScholarPubMed
Manley, MJ, de Jonge, P, Kershaw, TS, Desai, RA, Lin, H, Kasl, SV (2009). Association of major depression with subtypes of nicotine dependence found among adult daily smokers: a latent class analysis. Drug and Alcohol Dependence 104, 126–132.CrossRefGoogle ScholarPubMed
McCaffery, JM, Niaura, R, Swan, GE, Carmelli, D (2003). A study of depressive symptoms and smoking behavior in adult male twins from the NHLBI twin study. Nicotine and Tobacco Research 5, 77–83.CrossRefGoogle ScholarPubMed
McCaffery, JM, Papandonatos, GD, Stanton, C, Lloyd-Richardson, EE, Niaura, R (2008). Depressive symptoms and cigarette smoking in twins from the National Longitudinal Study of Adolescent Health. Health Psychology 27, S207–S215.CrossRefGoogle ScholarPubMed
Neale, MC, Boker, SM, Xie, G, Maes, HH (2003). Mx: Statistical Modeling. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University: Richmond, VA.Google Scholar
Parrott, AC (2006). Nicotine psychobiology: how chronic-dose prospective studies can illuminate some of the theoretical issues from acute-dose research. Psychopharmacology 184, 567–576.CrossRefGoogle ScholarPubMed
Pedersen, NL, Lichtenstein, P, Svedberg, P (2002). The Swedish Twin Registry in the third millennium. Twin Research 5, 427–432.CrossRefGoogle ScholarPubMed
Schmitt, JE, Prescott, CA, Gardner, CO, Neale, MC, Kendler, KS (2005). The differential heritability of regular tobacco use based on method of administration. Twin Research and Human Genetics 8, 60–62.Google ScholarPubMed
Sihvola, E, Rose, RJ, Dick, DM, Pulkkinen, L, Marttunen, M, Kaprio, J (2008). Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins. Addiction 103, 2045–2053.CrossRefGoogle ScholarPubMed
Tiemeier, H (2003). Biological risk factors for late life depression. European Journal of Epidemiology 18, 745–750.CrossRefGoogle ScholarPubMed
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