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Patterns of subjective memory impairment in the elderly: association with memory performance

Published online by Cambridge University Press:  11 July 2007

FRANK JESSEN ,
BIRGITT WIESE ,
GABRIELA CVETANOVSKA ,
ANGELA FUCHS ,
HANNA KADUSZKIEWICZ ,
HEIKE KÖLSCH ,
TOBIAS LUCK ,
EDELGARD MÖSCH ,
MICHAEL PENTZEK  and
STEFFI G. RIEDEL-HELLER
...Show all authors
FRANK JESSEN*
Affiliation:
Department of Psychiatry, University of Bonn, Germany
BIRGITT WIESE
Affiliation:
Institute for Biometrics, Hannover Medical School, Germany
GABRIELA CVETANOVSKA
Affiliation:
Department of Psychiatry, University of Bonn, Germany
ANGELA FUCHS
Affiliation:
Department of General Practice, University Medical Centre, Düsseldorf, Germany
HANNA KADUSZKIEWICZ
Affiliation:
Department of Primary Medical Care, University Medical Centre, Hamburg-Eppendorf, Germany
HEIKE KÖLSCH
Affiliation:
Department of Psychiatry, University of Bonn, Germany
TOBIAS LUCK
Affiliation:
Department of Psychiatry, University of Leipzig, Germany
EDELGARD MÖSCH
Affiliation:
Department of Psychiatry, Technical University, Munich, Germany
MICHAEL PENTZEK
Affiliation:
Department of General Practice, University Medical Centre, Düsseldorf, Germany
STEFFI G. RIEDEL-HELLER
Affiliation:
Department of Psychiatry, University of Leipzig, Germany
JOCHEN WERLE
Affiliation:
Central Institute for Mental Health, Mannheim, Germany
SIEGFRIED WEYERER
Affiliation:
Central Institute for Mental Health, Mannheim, Germany
THOMAS ZIMMERMANN
Affiliation:
Department of Primary Medical Care, University Medical Centre, Hamburg-Eppendorf, Germany
WOLFGANG MAIER
Affiliation:
Department of Psychiatry, University of Bonn, Germany
HORST BICKEL
Affiliation:
Department of Psychiatry, Technical University, Munich, Germany
*
*Address for correspondence: Frank Jessen, M.D., Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. (Email: [email protected])
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Abstract

Background

The association of subjective memory impairment (SMI) with cognitive performance in healthy elderly subjects is poor because of confounds such as depression. However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline.

Method

A total of 2389 unimpaired subjects were recruited from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe), as part of the German Competence Network on Dementia. Clusters of SMI according to patterns of response to SMI questions were identified. Gender, age, depressive symptoms, apolipoprotein E (apoE) genotype, delayed recall and verbal fluency were included in a Classification and Regression Tree (CART) analysis to identify discriminators between the clusters.

Results

We identified three clusters. Cluster 1 contained subjects without memory complaints. Cluster 2 contained subjects with general memory complaints, but mainly without memory complaints on individual tasks of daily living. Cluster 3 contained subjects with general memory complaints and complaints on individual tasks of daily living. Depressive symptoms, as the first-level discriminator, distinguished between clusters 1 and 2 versus cluster 3. In subjects with only a few depressive symptoms, delayed recall discriminated between cluster 1 versus clusters 2 and 3.

Conclusions

In SMI subjects with only a minor number of depressive symptoms, memory complaints are associated with delayed recall. As delayed recall is a sensitive predictor for future cognitive decline, SMI may be the first manifestation of future dementia in elderly subjects without depression.

Type
Original Article
Information
Psychological Medicine , Volume 37 , Issue 12 , December 2007 , pp. 1753 - 1762
Copyright
Copyright © Cambridge University Press 2007

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References

REFERENCES

Alvarez, J. A. & Emory, E. (2006). Executive function and the frontal lobes: a meta-analytic review. Neuropsychological Review 16, 17–42.CrossRefGoogle ScholarPubMed
Bäckman, L., Small, B. J. & Fratiglioni, L. (2001). Stability of the preclinical episodic memory deficit in Alzheimer's disease. Brain 124, 96–102.CrossRefGoogle ScholarPubMed
Barnes, L. L., Schneider, J. A., Boyle, P. A., Bienias, J. L. & Bennett, D. A. (2006). Memory complaints are related to Alzheimer disease pathology in older persons. Neurology 67, 1581–1585.CrossRefGoogle ScholarPubMed
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C. & Wilson, R. S. (2006). Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66, 1837–1844.Google Scholar
Blair, C. K., Folsom, A. R., Knopman, D. S., Bray, M. S., Mosley, T. H. & Boerwinkle, E.; Atherosclerosis Risk in Communities (ARIC) Study Investigators (2005). APOE genotype and cognitive decline in a middle-aged cohort. Neurology 64, 268–276.Google Scholar
Braak, H. & Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologia (Berlin) 82, 239–259.CrossRefGoogle ScholarPubMed
Breiman, L., Friedman, J. H., Olshen, R. A. & Stone, C. J. (1984). Classification and Regression Trees. Wadsworth: Belmont, CA.Google Scholar
Busse, A., Aurich, C., Zaudig, M., Riedel-Heller, S., Matschinger, H. & Angermayer, M. C. (2002). Age- and education-specific reference values for the cognitive test of the SIDAM (Structured Interview for the Diagnosis of Dementia of the Alzheimer type, Multi-infarct dementia and dementias of other etiology according to ICD-10 and DSM-IV). Zeitschrift für Gerontologie und Geriatrie 35, 565–574.Google Scholar
Busse, A., Hensel, A., Guhne, U., Angermeyer, M. C. & Riedel-Heller, S. G. (2006). Mild cognitive impairment: long-term course of four clinical subtypes. Neurology 67, 2176–2185.CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, M. E. & McHugh, P. R. (1975). ‘Mini-Mental State’: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatry Research 12, 189–198.CrossRefGoogle Scholar
Gagnon, M., Dartigues, J. F., Mazaux, J. M., Dequae, L., Letenneur, L., Giroire, J. M. & Barberger-Gateau, P. (1994). Self-reported memory complaints and memory performance in elderly French community residents: results of the PAQUID Research Program. Neuroepidemiology 13, 145–154.Google Scholar
Gauthier, S., Reisberg, B., Zaudig, M., Petersen, R. C., Ritchie, K., Broich, K., Belleville, S., Brodaty, H., Bennett, D., Chertkow, H., Cummings, J. L., de Leon, M., Feldman, H., Ganguli, M., Hampel, H., Scheltens, P., Tierney, M. C., Whitehouse, P. & Winblad, B.; International Psychogeriatric Association Expert Conference on mild cognitive impairment (2006). Mild cognitive impairment. Lancet 367, 1262–1270.CrossRefGoogle ScholarPubMed
Ghebremedhin, E., Schultz, C., Thal, D. R., Rub, U., Ohm, T. G., Braak, E. & Braak, H. (2001). Gender and age modify the association between APOE and AD-related neuropathology. Neurology 56, 1696–1701.CrossRefGoogle ScholarPubMed
Hanninen, T., Reinikainen, K. J., Helkala, E. L., Koivisto, K., Mykkanen, L., Laakso, M., Pyorala, K. & Riekkinen, P. J. (1994). Subjective memory complaints and personality traits in normal elderly subjects. Journal of the American Geriatrics Society 42, 1–4.Google Scholar
Heun, R., Kolsch, H. & Jessen, F. (2006). Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD. European Archives of Psychiatry and Clinical Neuroscience 256, 28–36.CrossRefGoogle Scholar
Hixson, J. E. & Vernier, D. T. (1990). Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. Journal of Lipid Research 31, 545–548.CrossRefGoogle ScholarPubMed
Jessen, F., Feyen, L., Freymann, K., Tepest, R., Maier, W., Heun, R., Schild, H. H. & Scheef, L. (2006). Volume reduction of the entorhinal cortex in subjective memory impairment. Neurobiology of Aging 27, 1751–1756.Google Scholar
Jonker, C., Geerlings, M. I. & Schmand, B. (2000). Are memory complaints predictive for dementia? A review of clinical and population-based studies. International Journal of Geriatric Psychiatry 15, 983–991.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Jonker, C., Launer, L. J., Hooijer, C. & Lindeboom, J. (1996). Memory complaints and memory impairment in older individuals. Journal of the American Geriatrics Society 44, 44–49.Google Scholar
Jorm, A. F., Butterworth, P., Anstey, K. J., Christensen, H., Easteal, S., Maller, J., Mather, K. A., Turakulov, R. I., Wen, W. & Sachdev, P. (2004 a). Memory complaints in a community sample aged 60–64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities. Psychological Medicine 34, 1495–1506.CrossRefGoogle Scholar
Jorm, A. F., Christensen, H., Korten, A. E., Jacomb, P. A. & Henderson, A. S. (2001). Memory complaints as a precursor of memory impairment in older people: a longitudinal analysis over 7–8 years. Psychological Medicine 31, 441–449.Google Scholar
Jorm, A. F., Masaki, K. H., Davis, D. G., Hardman, J., Nelson, J., Markesbery, W. R., Petrovitch, H., Ross, G. W. & White, L. R. (2004 b). Memory complaints in nondemented men predict future pathologic diagnosis of Alzheimer disease. Neurology 63, 1960–1961.Google Scholar
Jungwirth, S., Fischer, P., Weissgram, S., Kirchmeyr, W., Bauer, P. & Tragl, K. H. (2004). Subjective memory complaints and objective memory impairment in the Vienna-Transdanube aging community. Journal of the American Geriatrics Society 52, 263–268.CrossRefGoogle ScholarPubMed
Kaufman, L. & Rousseeuw, P. J. (2005). Finding Groups in Data. Wiley: New York.Google Scholar
Khachaturian, A. S., Corcoran, C. D., Mayer, L. S., Zandi, P. P. & Breitner, J. C.; Cache County Study Investigators (2004). Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: the Cache County Study. Archives of General Psychiatry 61, 518–524.Google Scholar
Markesbery, W. R., Schmitt, F. A., Kryscio, R. J., Davis, D. G., Smith, C. D. & Wekstein, D. R. (2006). Neuropathologic substrate of mild cognitive impairment. Archives of Neurology 63, 38–46.Google Scholar
Mayeux, R., Small, S. A., Tang, M., Tycko, B. & Stern, Y. (2001). Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiology of Aging 22, 683–689.Google Scholar
Morris, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D. & Clark, C. (1989). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39, 1159–1165.Google Scholar
Moscovitch, M., Nadel, L., Winocur, G., Gilboa, A. & Rosenbaum, R. S. (2006). The cognitive neuroscience of remote episodic, semantic and spatial memory. Current Opinion in Neurobiology 16, 179–190.Google Scholar
Nilsson, L. G., Adolfsson, R., Backman, L., Cruts, M., Nyberg, L., Small, B. J. & Van Broeckoven, C. (2006). The influence of APOE status on episodic and semantic memory: data from a population-based study. Neuropsychology 20, 645–657.CrossRefGoogle ScholarPubMed
O'Connor, D. W., Pollitt, P. A., Roth, M., Brook, P. B. & Reiss, B. B. (1990). Memory complaints and impairment in normal, depressed, and demented elderly persons identified in a community survey. Archives of General Psychiatry 47, 224–227.CrossRefGoogle Scholar
Ponds, R. W., Commissaris, K. J. & Jolles, J. (1997). Prevalence and covariates of subjective forgetfulness in a normal population in The Netherlands. International Journal of Aging and Human Development 45, 207–221.CrossRefGoogle Scholar
Reid, L. M. & MacLullich, A. M. (2006). Subjective memory complaints and cognitive impairment in older people. Dementia and Geriatric Cognitive Disorders 22, 471–485.Google Scholar
Riedel-Heller, S. G., Matschinger, H., Schork, A. & Angermeyer, M. C. (1999). Do memory complaints indicate the presence of cognitive impairment? Results of a field study. European Archives of Psychiatry and Clinical Neuroscience 249, 197–204.Google Scholar
Riley, K. P., Snowdon, D. A. & Markesbery, W. R. (2002). Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Annals of Neurology 51, 567–577.Google Scholar
Riudavets, M. A., Rubio, A., Cox, C., Rudow, G., Fowler, D. & Troncoso, J. C. (2006). The prevalence of Alzheimer neuropathologic lesions is similar in Blacks and Whites. Journal of Neuropathology and Experimental Neurology 65, 1143–1148.Google Scholar
Rubinsztein, D. C. & Easton, D. F. (1999). Apolipoprotein E genetic variation and Alzheimer's disease: a meta-analysis. Dementia and Geriatric Cognitive Disorders 10, 199–209.Google Scholar
Saykin, A. J., Wishart, H. A., Rabin, L. A., Santulli, R. B., Flashman, L. A., West, J. D., McHugh, T. L. & Mamourian, A. C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology 67, 834–842.Google Scholar
van der Flier, W. M., van Buchem, M. A., Weverling-Rijnsburger, A. W., Mutsaers, E. R., Bollen, E. L., Admiraal-Behloul, F., Westendorp, R. G. & Middelkoop, H. A. (2004). Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. Journal of Neurology 251, 671–675.Google Scholar
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. O., Nordberg, A., Backman, L., Albert, M., Almkvist, O., Arai, H., Basun, H., Blennow, K., de Leon, M., DeCarli, C., Erkinjuntti, T., Giacobini, E., Graff, C., Hardy, J., Jack, C., Jorm, A., Ritchie, K., van Duijn, C., Visser, P. & Petersen, R. C. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine 256, 240–246.CrossRefGoogle Scholar
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M. & Leirer, V. O. (1982). Development and validation of a geriatric depression screening scale: a preliminary report. Journal of Psychiatry Research 17, 37–49.Google Scholar
Zaudig, M. (1992). A new systematic method of measurement and diagnosis of ‘mild cognitive impairment’ and dementia according to ICD-10 and DSM-III-R criteria. International Psychogeriatrics 4 (Suppl. 2), 203–219.CrossRefGoogle ScholarPubMed
Zaudig, M. & Hiller, W. (1996). SIDAM-Handbook. Structured Interview for Diagnosis of Dementia of Alzheimer type, Multi-infarct dementia and dementia of other aetiology according to DSM-IIIR, DSM-IV and ICD-10 [in German]. Huber: Bern.Google Scholar