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Mood swings associated with the ‘on—off’ phenomenon in Parkinson's disease

Published online by Cambridge University Press:  09 July 2009

H. Nissenbaum ,
N. P. Quinn ,
R. G. Brown ,
B. Toone ,
A.-M. Gotham  and
C. D. Marsden
H. Nissenbaum
Affiliation:
University Departments of Psychological Medicine and Neurology, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London
N. P. Quinn*
Affiliation:
University Departments of Psychological Medicine and Neurology, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London
R. G. Brown
Affiliation:
University Departments of Psychological Medicine and Neurology, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London
B. Toone
Affiliation:
University Departments of Psychological Medicine and Neurology, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London
A.-M. Gotham
Affiliation:
University Departments of Psychological Medicine and Neurology, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London
C. D. Marsden
Affiliation:
University Departments of Psychological Medicine and Neurology, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London
*
1Address for correspondence: Dr N. P. Quinn, Golla Ward, The Maudsley Hospital, De Crespigny Park, London SE5 8AZ.
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Synopsis

Mood swings accompanying the motor fluctuations of patients with Parkinson's disease on chronic levodopa treatment frequently occur, but are poorly recognized. Occasionally, their functional impact may be greater than that caused by the motor disability itself.

In this study we have assessed the nature of, and relationship between, mood and motor fluctuations in nine Parkinsonian patients with ‘on—off’ motor swings. The results of an additional questionnaire survey confirm that ‘on–off’ mood swings occur in approximately two thirds of patients with Parkinson's disease experiencing motor fluctuations on dopaminergic treatment. Aetiological and therapeutic implications are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 4 , November 1987 , pp. 899 - 904
Copyright
Copyright © Cambridge University Press 1987

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