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Methysergide in mania: a double-blind comparison with thioridazine

Published online by Cambridge University Press:  09 July 2009

H. B. McNamee ,
D. Le Poidevin  and
G. J. Naylor
H. B. McNamee
Affiliation:
Department of Psychiatry, University of Dundee, and Royal Dundee Liff Hospital
D. Le Poidevin
Affiliation:
Department of Psychiatry, University of Dundee, and Royal Dundee Liff Hospital
G. J. Naylor
Affiliation:
Department of Psychiatry, University of Dundee, and Royal Dundee Liff Hospital
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Synopsis

During 20 separate illnesses 17 severely disturbed manic patients were given either methysergide or thioridazine in a 21 day double-blind controlled trial. For most of the trial patients received either 9 mg methysergide or 450 mg thioridazine daily; during one 24-hour period 12 mg methysergide or 600 mg thioridazine was administered. Daily clinical assessments were made. Methysergide proved significantly less effective than the phenothiazine.

Type
Research Article
Information
Psychological Medicine , Volume 2 , Issue 1 , February 1972 , pp. 66 - 69
Copyright
Copyright © Cambridge University Press 1972

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References

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