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Maternal antenatal daytime sleepiness and child neuropsychiatric and neurocognitive development

Published online by Cambridge University Press:  08 October 2018

M. Lahti-Pulkkinen ,
T. H. Mina ,
R. L. Riha ,
K. Räikkönen ,
A. K. Pesonen ,
A. J. Drake ,
F. C. Denison  and
R. M. Reynolds Open the ORCID record for R. M. Reynolds [Opens in a new window]
M. Lahti-Pulkkinen
Affiliation:
British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
T. H. Mina
Affiliation:
British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK Tommy's Centre for Maternal and Fetal Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK
R. L. Riha
Affiliation:
Department of Sleep Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK
K. Räikkönen
Affiliation:
Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
A. K. Pesonen
Affiliation:
Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
A. J. Drake
Affiliation:
British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
F. C. Denison
Affiliation:
Tommy's Centre for Maternal and Fetal Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK
R. M. Reynolds*
Affiliation:
British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK Tommy's Centre for Maternal and Fetal Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK
*
Author for correspondence: R. M. Reynolds, E-mail: [email protected]
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Abstract

Background

The prevalence of sleep problems among pregnant women is over 50%, and daytime sleepiness is among the most common sleep problems. Previous studies have associated antenatal sleep problems with adverse maternal health and neonatal outcomes, but the consequences of antenatal sleep problems and particularly daytime sleepiness on child psychological development have not been assessed prospectively.

Methods

In this prospective cohort study including 111 mother-child dyads, we examined the associations of maternal daytime sleepiness during pregnancy, assessed at 17 and 28 weeks of gestation using the Epworth Sleepiness Scale, with child neuropsychiatric problems and neuropsychological development, assessed with mother-rated questionnaires and individually administered neuropsychological tests, at child age 2.6–5.7 years (mean = 4.3 years).

Results

Independently of sociodemographic and perinatal covariates and maternal depressive and anxiety symptoms during and/or after pregnancy, maternal antenatal daytime sleepiness was associated with increased total [unstandardized regression coefficient (B) = 0.25 standard deviation (s.d.) units; 95% confidence interval (CI) 0.01–0.48] and internalizing (B = 0.25 s.d.s: 95% CI 0.01–0.49) psychiatric problems and ADHD symptoms (B = 0.27 s.d.s: 95% CI 0.04–0.50) in children, and with poorer executive function, particularly in the areas of attention, working memory and inhibitory control (B = −0.39 s.d.s: 95% CI −0.69 to −0.10).

Conclusions

Maternal antenatal daytime sleepiness carries adverse consequences for offspring psychological development. The assessment of sleep problems may be an important addition to standard antenatal care.

Keywords

ADHDexecutive functionpregnancypsychiatricsleepiness
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 12 , September 2019 , pp. 2081 - 2090
Copyright
Copyright © Cambridge University Press 2018 

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