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Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder

Published online by Cambridge University Press:  09 July 2009

Walter J. Muir ,
David M. St. Clair  and
Douglas H. R. Blackwood
Walter J. Muir*
Affiliation:
Department of Psychiatry, University of Edinburgh
David M. St. Clair
Affiliation:
Department of Psychiatry, University of Edinburgh
Douglas H. R. Blackwood
Affiliation:
Department of Psychiatry, University of Edinburgh
*
1Address for correspondence: Dr Walter J. Muir, Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF.
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Synopsis

Long-latency auditory event-related potentials were examined in 96 subjects with schizophrenia, 99 with bipolar affective disorder and 48 with major depressive (unipolar) disorder, and compared with 32 in-patient and 213 normal controls. The latency of the P3 component was significantly greater in the schizophrenic and bipolar subjects compared to other groups. The difference was stable with respect to clinical state at the time of testing and was not due to age differences or the effect of psychotropic medications. The results support the clinical distinction between bipolar and unipolar affective disorders, but also show that P3 change is not specific to schizophrenia and found in bipolar but not unipolar affective disorder.

Type
Original Articles
Information
Psychological Medicine , Volume 21 , Issue 4 , November 1991 , pp. 867 - 879
Copyright
Copyright © Cambridge University Press 1991

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