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Lithium therapy and alkaline earth metal metabolism: a biochemical screening study

Published online by Cambridge University Press:  09 July 2009

N. J. Birch*
Affiliation:
From the Department of Biochemistry, University of Leeds, and the Computing and Statistics Section, British Iron and Steel Research Association, Sheffield
A. A. Greenfield
Affiliation:
From the Department of Biochemistry, University of Leeds, and the Computing and Statistics Section, British Iron and Steel Research Association, Sheffield
R. P. Hullin
Affiliation:
From the Department of Biochemistry, University of Leeds, and the Computing and Statistics Section, British Iron and Steel Research Association, Sheffield
*
1Address for correspondence: Dr N. J. Birch, Department of Biochemistry, University of Leeds, 9 Hyde Terrace, Leeds LS2 9LS

Synopsis

A study is described of 90 patients receiving lithium prophylactically for recurrent affective disorder. A total of 90 biochemical variables was analysed by correlation matrices. No abnormality in calcium or magnesium metabolism was detected though this may merely be a reflection of the insensitivity of the screening technique used.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1977

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References

Andreoli, V. M., Villani, F. & Brambilla, G. (1972). Increased magnesium and calcium excretion induced by lithium carbonate. Psychopharmacologia 25, 7785.CrossRefGoogle ScholarPubMed
Aronoff, M. S., Evens, R. G. & Durell, J. (1971). Effect of lithium salts on electrolyte metabolism. Journal of Psychiatric Research 8, 139159.CrossRefGoogle ScholarPubMed
Baron, D. N. (1970). A Short Textbook of Chemical Pathology (2nd edn). English Universities Press: London.Google Scholar
Birch, N. J. (1970). Lithium and plasma magnesium. British Journal of Psychiatry 116, 461.CrossRefGoogle ScholarPubMed
Birch, N. J. (1971). A study of the effects of lithium salts on the distribution and excretion of other ions. Ph.D. Thesis, University of Sheffield. (British Library, Lending Division, Boston Spa, Yorkshire. Microfilm No. D3225/73.)Google Scholar
Birch, N. J. (1974 a). Lithium and magnesium dependent enzymes. Lancet ii, 965966.CrossRefGoogle Scholar
Birch, N. J. (1974 b). Lithium accumulation in bone after oral administration in rat and in man. Clinical Science and Molecular Medicine 46, 409413.Google ScholarPubMed
Birch, N. J. & Hullin, R. P. (1972). The distribution and binding of lithium following its long-term administration. Life Sciences 11, 10951099.CrossRefGoogle ScholarPubMed
Birch, N. J. & Jenner, F. A. (1973). The distribution of lithium and its effects on the distribution and excretion of other ions in the rat. British Journal of Pharmacology 47, 586594.CrossRefGoogle ScholarPubMed
Birch, N. J., Greenfield, A. A. & Hullin, R. P. (1974). A metabolic profile of patients receiving prophylactic lithium therapy. British Journal of Pharmacology 52, 443P.Google ScholarPubMed
Birch, N. J., Greenfield, A. A. & Hullin, R. P. (1977). Pharmacodynamic aspects of lithium prophylaxis. Submitted for publication.Google Scholar
Briscoe, A. M. & Ragan, C. (1967). Relation of magnesium to calcium in human blood serum. Nature 214, 11261127.CrossRefGoogle ScholarPubMed
Bunney, W. E., Goodwin, F. K., Davis, J. M. & Fawcett, J. A. (1968). A behavioural-biochemical study of lithium treatment. American Journal of Psychiatry 125, 499512.CrossRefGoogle Scholar
Carman, J. S., Post, R. M., Teplitz, T. A. & Goodwin, F. K. (1974). Divalent cations in predicting antidepressant response to lithium. Lancet ii, 1454.CrossRefGoogle Scholar
Crammer, J. (1975). Lithium, calcium and mental illness. Lancet i, 215216.CrossRefGoogle Scholar
Creek, R. D., Lund, P., Thomas, D. P. & Pollard, W. O. (1971). The effect of lithium carbonate on eggshell formation and serum calcium level of the hen. Poultry Science 50, 577580.CrossRefGoogle ScholarPubMed
Dauncey, M. J. & Widdowson, E. M. (1972). Urinary excretion of calcium, magnesium, sodium and potassium in hard and soft water areas. Lancet i, 711714.CrossRefGoogle Scholar
DuBois, D. & DuBois, E. F. (1916). Clinical calorimetry. A formula to estimate the approximate surface area if height and weight be known. Archives of Internal Medicine 17, 863871.CrossRefGoogle Scholar
Dunner, D. L., Meltzer, H. L., Schreiner, H. C. & Fiegelson, J. L. (1975). Plasma and erythrocyte magnesium levels in patients with primary affective disorder during chronic lithium treatment. Acta Psychiatrica Scandinavica 51, 104109.CrossRefGoogle ScholarPubMed
Eastham, R. D. (1971). Biochemical Values in Clinical Medicine (4th edn). John Wright: Bristol.Google Scholar
Frausto da Silva, J. J. R. & Williams, R. J. P. (1976). Possible mechanism for the biological action of lithium. Nature 263, 237239.CrossRefGoogle ScholarPubMed
Gallagher, J. C., Young, M. M. & Nordin, B. E. C. (1972). The effect of artificial menopause on plasma and urine calcium and phosphate. Clinical Endocrinology 1, 5764.CrossRefGoogle ScholarPubMed
Gotfredsen, C. F. & Rafaelsen, O. J. (1970). Effect of lithium and other psychopharmaca on rat electrolyte metabolism. International Pharmacopsychiatry 5, 242248.CrossRefGoogle Scholar
Hullin, R. P., McDonald, R. & Allsopp, M. N. E. (1975). Further report on prophylactic lithium in recurrent affective disorders. British Journal of Psychiatry 126, 281284.CrossRefGoogle Scholar
Lindgärde, F. (1972). Potentiometric determination of serumionized calcium in a normal human population. Clinica Chimica Acta 40, 477484.CrossRefGoogle Scholar
Mellerup, E. T. & Plenge, P. (1976). Lithium effects on magnesium, calcium and phosphate metabolism in rats. International Pharmacopsychiatry 11, 190195.CrossRefGoogle ScholarPubMed
Mellerup, E. T., Plenge, P., Ziegler, R. & Rafaelsen, O. J. (1970). Lithium effects on calcium metabolism in rats. International Pharmacopsychiatry 5, 258264.CrossRefGoogle Scholar
Nielsen, J. (1964). Magnesium lithium studies. I. Serum and erythrocyte magnesium in patients with manic states during lithium treatment. Acta Psychiatrica Scandinavica 40, 190196.CrossRefGoogle ScholarPubMed
Nordin, B. E. C., Hodgkinson, A. & Peacock, M. (1967). The measurement and the meaning of urinary calcium. Clinical Orthopaedics 52, 293322.CrossRefGoogle ScholarPubMed
Rousselet, F. & Durlach, J. (1971). Méthodes analytiques et exploration practique du métabolisme du magnésium en clinique humaine. 1er. Symposium International sur le Deficit Magnésique en Pathologie Humaine 1, Volume des Rapports (ed. Durlach, J.), pp. 6590. S.G.E.M.V.: Vittel.Google Scholar
Schou, M. (1968). Lithium in psychiatric therapy and prophylaxis. Journal of Psychiatric Research 6, 6795.CrossRefGoogle ScholarPubMed
Scott, J. T., Fergusson, T. M., Bradley, J. W. & Greger, C. R. (1973). The effects of low levels of lithium chloride in the diet of the laying hen. Poultry Science 52, 23362337.CrossRefGoogle ScholarPubMed
Seelig, M. S. & Berger, A. R. (1974). Range of normal serum magnesium values. New England Journal of Medicine 290, 974975.Google Scholar
Shaw, D. M. (1973). Effects of lithium salts on amine metabolism and electrolytes. Biochemistry Society Transactions 1, 7881.CrossRefGoogle Scholar
Varley, H. (1967). Practical Clinical Biochemistry (4th edn). Heinemann: London.Google Scholar
Wacker, W. E. C. & Parisi, A. F. (1968). Magnesium metabolism. New England Journal of Medicine 278, 658663.CrossRefGoogle ScholarPubMed
Wills, M. R. (1969). The urinary calcium/creatinine ratio as a measure of urinary calcium excretion. Journal of Clinical Pathology 22, 287290.CrossRefGoogle ScholarPubMed