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Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects

Published online by Cambridge University Press:  09 July 2009

G. J. Naylor ,
A. Smith ,
L. J. Boardman ,
D. A. T. Dick ,
E. G. Dick  and
P. Dick
G. J. Naylor*
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
A. Smith
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
L. J. Boardman
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
D. A. T. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
E. G. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
P. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
*
1Address for correspondence: Dr G. J. Naylor, Department of Psychiatry, Ninewells Hospital and Medical School, Dundee.
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Synopsis

Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies of lithium in manic depressive psychosis. The fluctuations in the erythrocyte membrane cation carrier were studied in 5 normal subjects over 12 weeks and the correlations between the parameters calculated. The erythrocyte sodium concentration correlated positively with the ouabain sensitive potassium influx. This too contrasts with findings in manic depressive psychosis.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 2 , May 1977 , pp. 229 - 233
Copyright
Copyright © Cambridge University Press 1977

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References

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