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Life events, anxious depression and personality: a prospective and genetic study

Published online by Cambridge University Press:  25 February 2008

C. M. Middeldorp ,
D. C. Cath ,
A. L. Beem ,
G. Willemsen  and
D. I. Boomsma
C. M. Middeldorp*
Affiliation:
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
D. C. Cath
Affiliation:
Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
A. L. Beem
Affiliation:
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
G. Willemsen
Affiliation:
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
D. I. Boomsma
Affiliation:
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
*
*Address for correspondence: Dr C. M. Middeldorp, Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081BT, Amsterdam, The Netherlands. (Email: [email protected])
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Abstract

Background

The association between life events and anxious depression might be due to causality or to gene–environment correlation. We examined unidirectional and reciprocal causality and a gene–environment correlation model, in which genes that influence the vulnerability for anxious depression also increase the risk of exposure to life events. The effect of genes that influence environmental exposure might be mediated through personality and we therefore also examined the association between life events and personality (neuroticism and extraversion).

Method

Information on life events, anxious depression, neuroticism and extraversion was collected in 5782 monozygotic (MZ) and dizygotic (DZ) twins who participated in a longitudinal survey study of the Netherlands Twin Register. To examine causality, data were analysed longitudinally. To examine gene–environment correlation, the co-twin control method was used.

Results

Anxious depression and, to a lesser extent, neuroticism scores increased after exposure to life events. Anxious depression and neuroticism also predicted the experience of life events. Prospectively, extraversion was not associated with life events. Anxious depression, neuroticism and extraversion scores did not differ between the non-exposed subjects of MZ and DZ twin pairs and unrelated subjects discordant for life events.

Conclusions

Our findings suggest that reciprocal causation explains the relationship between life events and anxious depression and between life events and neuroticism. Extraversion is not related to life events. No evidence was found for gene–environment correlation, i.e. the genes that influence anxious depression, neuroticism or extraversion do not overlap with the genes that increase the risk of exposure to life events.

Keywords

Anxietydepressionlife eventspersonality
Type
Original Articles
Information
Psychological Medicine , Volume 38 , Issue 11 , November 2008 , pp. 1557 - 1565
Copyright
Copyright © 2008 Cambridge University Press

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References

Achenbach, TM (1990). The Young Adult Self Report. University of Vermont, Department of Psychiatry: Burlington, VT.Google Scholar
APA (1994). Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th edn. American Psychiatric Press: Washington, DC.Google Scholar
Blaney, PH (1986). Affect and memory: a review. Psychological Bulletin 99, 229–246.CrossRefGoogle ScholarPubMed
Boomsma, DI, de Geus, EJ, Vink, JM, Stubbe, JH, Distel, MA, Hottenga, JJ, Posthuma, D, van Beijsterveldt, TC, Hudziak, JJ, Bartels, M, Willemsen, G (2006). Netherlands Twin Register: from twins to twin families. Twin Research and Human Genetics 9, 849–857.CrossRefGoogle ScholarPubMed
Boomsma, DI, Vink, JM, van Beijsterveldt, TC, de Geus, EJ, Beem, AL, Mulder, EJ, Derks, EM, Riese, H, Willemsen, GA, Bartels, M, van den Berg, M, Kupper, NH, Polderman, TJ, Posthuma, D, Rietveld, MJ, Stubbe, JH, Knol, LI, Stroet, T, van Baal, GC (2002). Netherlands Twin Register: a focus on longitudinal research. Twin Research 5, 401–406.CrossRefGoogle Scholar
Cederlof, R, Friberg, L, Lundman, T (1977). The interactions of smoking, environment and heredity and their implications for disease etiology. A report of epidemiological studies on the Swedish twin registries. Acta Medica Scandinavica (Suppl.) 612, 1–128.Google ScholarPubMed
de Graaf, R, Bijl, RV, Ravelli, A, Smit, F, Vollebergh, WAM (2002). Predictors of first incidence of DSM-III-R psychiatric disorders in the general population: findings from the Netherlands Mental Health Survey and Incidence Study. Acta Psychiatrica Scandinavica 106, 303–313.Google Scholar
Doyle, R, Mick, E, Biederman, J (2007). Convergence between the Achenbach Youth Self-Report and Structured Diagnostic Interview diagnoses in ADHD and non-ADHD youth. Journal of Nervous and Mental Disease 195, 350–352.CrossRefGoogle ScholarPubMed
Eysenck, HJ, Eysenck, SBG (1964). Eysenck Personality Inventory. Educational Industrial Testing Service: San Diego, CA.Google Scholar
Faravelli, C, Pallanti, S (1989). Recent life events and panic disorder. American Journal of Psychiatry 146, 622–626.Google ScholarPubMed
Farmer, A, Harris, T, Redman, K, Sadler, S, Mahmood, A, McGuffin, P (2000). Cardiff Depression Study. A sib-pair study of life events and familiality in major depression. British Journal of Psychiatry 176, 150–155.CrossRefGoogle ScholarPubMed
Fergusson, DM, Horwood, LJ (1987). Vulnerability to life events exposure. Psychological Medicine 17, 739–749.CrossRefGoogle ScholarPubMed
Hammen, C (2003). Social stress and women's risk for recurrent depression. Archives of Women's Health 6, 9–13.CrossRefGoogle ScholarPubMed
Karney, BR, Bradbury, TN (1995). The longitudinal course of marital quality and stability: a review of theory, method, and research. Psychological Bulletin 118, 3–34.CrossRefGoogle ScholarPubMed
Kendler, KS, Eaves, LJ (1986). Models for the joint effect of genotype and environment on liability to psychiatric illness. American Journal of Psychiatry 143, 279–289.Google ScholarPubMed
Kendler, KS, Gardner, CO, Prescott, CA (2003 a). Personality and the experience of environmental adversity. Psychological Medicine 33, 1193–1202.CrossRefGoogle ScholarPubMed
Kendler, KS, Hettema, JM, Butera, F, Gardner, CO, Prescott, CA (2003 b). Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Archives of General Psychiatry 60, 789–796.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski, LM, Prescott, CA (1998). Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. Journal of Nervous and Mental Disease 186, 661–669.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski, LM, Prescott, CA (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry 156, 837–841.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski-Shuman, L (1997). Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychological Medicine 27, 539–547.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, MacLean, CJ, Heath, AC, Eaves, LJ, Kessler, RC (1993). Smoking and major depression. A causal analysis. Archives of General Psychiatry 50, 36–43.CrossRefGoogle ScholarPubMed
Lucas, RE (2005). Time does not heal all wounds. Psychological Science 16, 945–950.CrossRefGoogle ScholarPubMed
Magnus, K, Diener, E, Fujita, F, Pavot, W (1993). Extraversion and neuroticism as predictors of objective life events: a longitudinal analysis. Journal of Personality and Social Psychology 65, 1046–1053.CrossRefGoogle ScholarPubMed
McGuffin, P, Katz, R, Bebbington, P (1988). The Camberwell Collaborative Depression Study. III. Depression and adversity in the relatives of depressed probands. British Journal of Psychiatry 152, 775–782.CrossRefGoogle ScholarPubMed
Middeldorp, CM, Cath, DC, van den Berg, M, Beem, AL, van Dyck, R, Boomsma, DI (2006). The association of personality with anxious and depressive psychopathology. In The Biological Basis of Personality and Individual Differences (ed. Canli, T.), pp. 251–272. Guilford Press: New York.Google Scholar
Middeldorp, CM, Cath, DC, Vink, JM, Boomsma, DI (2005). Twin and genetic effects on life events. Twin Research and Human Genetics 8, 224–231.CrossRefGoogle ScholarPubMed
Moffitt, TE, Caspi, A, Rutter, M (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 62, 473–481.CrossRefGoogle ScholarPubMed
Newman, SC, Bland, RC (1994). Life events and the 1-year prevalence of major depressive episode, generalized anxiety disorder, and panic disorder in a community sample. Comprehensive Psychiatry 35, 76–82.CrossRefGoogle Scholar
Ormel, J, Oldehinkel, AJ, Brilman, EI (2001). The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first and recurrent depressive episodes in later life. American Journal of Psychiatry 158, 885–891.CrossRefGoogle ScholarPubMed
Ormel, J, Wohlfarth, T (1991). How neuroticism, long-term difficulties, and life situation change influence psychological distress: a longitudinal model. Journal of Personality and Social Psychology 60, 744–755.CrossRefGoogle ScholarPubMed
Patton, GC, Coffey, C, Posterino, M, Carlin, JB, Bowes, G (2003). Life events and early onset depression: cause or consequence? Psychological Medicine 33, 1203–1210.CrossRefGoogle ScholarPubMed
Paykel, ES (1983). Methodological aspects of life events research. Journal of Psychosomatic Research 27, 341–352.CrossRefGoogle ScholarPubMed
Paykel, ES (2003). Life events and affective disorders. Acta Psychiatrica Scandinavica 108 (Suppl. 418), 61–66.CrossRefGoogle Scholar
Poulton, RG, Andrews, G (1992). Personality as a cause of adverse life events. Acta Psychiatrica Scandinavica 85, 35–38.CrossRefGoogle ScholarPubMed
Purcell, S (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research 5, 554–571.CrossRefGoogle ScholarPubMed
Romanov, K, Varjonen, J, Kaprio, J, Koskenvuo, M (2003). Life events and depressiveness – the effect of adjustment for psychosocial factors, somatic health and genetic liability. Acta Psychiatrica Scandinavica 107, 25–33.CrossRefGoogle ScholarPubMed
Sandin, B, Chorot, P, Santed, MA, Valiente, RM (2004). Differences in negative life events between patients with anxiety disorders, depression and hypochondriasis. Anxiety Stress and Coping 17, 37–47.CrossRefGoogle Scholar
Saudino, KJ, Pedersen, NL, Lichtenstein, P, McClearn, GE, Plomin, R (1997). Can personality explain genetic influences on life events? Journal of Personality and Social Psychology 72, 196–206.CrossRefGoogle ScholarPubMed
Vaidya, JG, Gray, EK, Haig, J, Watson, D (2002). On the temporal stability of personality: evidence for differential stability and the role of life experiences. Journal of Personality and Social Psychology 83, 1469–1484.CrossRefGoogle ScholarPubMed
Van der Velden, PG, Van der Burg, S, Steinmetz, CHD, Van den Bout, J (1992). Slachtoffers van Bankovervallen [Victims of Bank Robberies]. Bohn Stafleu Van Loghum: Houten, The Netherlands.Google Scholar
van Os, J, Park, SB, Jones, PB (2001). Neuroticism, life events and mental health: evidence for person–environment correlation. British Journal of Psychiatry (Suppl.) 40, s72–s77.Google Scholar
Verhulst, FC, Ende, JV, Koot, HM (1997). Handleiding voor de Youth Self Report [Guide for the Youth Self Report]. Afdeling Kinder- en Jeugdpsychiatrie, Sophia Kinderziekenhuis/Academisch Ziekenhuis Rotterdam/Erasmus Universiteit Rotterdam: Rotterdam, The Netherlands.Google Scholar
Wilde, GJS (1970). Neurotische Labiliteit Gemeten Volgens de Vragenlijstmethode [The Questionnaire Method as a Means of Measuring Neurotic Instability]. Van Rossen: Amsterdam, The Netherlands.Google Scholar
Willemsen, G, Posthuma, D, Boomsma, DI (2005). Environmental factors determine where the Dutch live: results from the Netherlands twin register. Twin Research Human Genetics 8, 312–317.Google Scholar