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Inhibition of entry of some amino acids into the brain, with observations on mental retardation in the aminoacidurias

Published online by Cambridge University Press:  09 July 2009

Guadalupe Baños ,
P. M. Daniel ,
S. R. Moorhouse  and
O. E. Pratt
Guadalupe Baños
Affiliation:
Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London
P. M. Daniel
Affiliation:
Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London
S. R. Moorhouse
Affiliation:
Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London
O. E. Pratt
Affiliation:
Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London
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Sysnopsis

Abnormally high levels of various amino acids were maintained in the bloodstream of rats, causing saturation of amino acid transport into the brain and partial exclusion from the brain of other amino acids which are necessary for protein synthesis. Excluded amino acids could be made to enter the brain by raising their concentration in the bloodstream. The possible relevance of these findings to improvements in the dietary treatment of some inborn errors of metabolism is discussed.

Type
Research Article
Information
Psychological Medicine , Volume 4 , Issue 3 , August 1974 , pp. 262 - 269
Copyright
Copyright © Cambridge University Press 1974

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References

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