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Increased amygdala-visual cortex connectivity in youth with persecutory ideation

Published online by Cambridge University Press:  12 February 2019

Stephanie N. DeCross Open the ORCID record for Stephanie N. DeCross [Opens in a new window] ,
Amy H. Farabaugh ,
Avram J. Holmes ,
Maeve Ward ,
Emily A. Boeke ,
Rick P. F. Wolthusen ,
Garth Coombs III ,
Maren Nyer ,
Maurizio Fava  and
Randy L. Buckner
...Show all authors
Stephanie N. DeCross
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Psychology, Harvard University, Cambridge, MA, USA
Amy H. Farabaugh
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Avram J. Holmes
Affiliation:
Department of Psychology, Yale University, New Haven, CT, USA
Maeve Ward
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Sidney Kimmel Medical College, Philadelphia, PA, USA
Emily A. Boeke
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Psychology, New York University, New York, NY, USA
Rick P. F. Wolthusen
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine Carl Gustav Carus of the Technische Universität Dresden, Dresden, Germany
Garth Coombs III
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Psychology, Harvard University, Cambridge, MA, USA
Maren Nyer
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Maurizio Fava
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Randy L. Buckner
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA Harvard Medical School, Boston, MA, USA Department of Psychology, Harvard University, Cambridge, MA, USA
Daphne J. Holt*
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA Harvard Medical School, Boston, MA, USA
*
Author for correspondence: Daphne J. Holt, E-mail: [email protected]
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Abstract

Background

Subclinical delusional ideas, including persecutory beliefs, in otherwise healthy individuals are heritable symptoms associated with increased risk for psychotic illness, possibly representing an expression of one end of a continuum of psychosis severity. The identification of variation in brain function associated with these symptoms may provide insights about the neurobiology of delusions in clinical psychosis.

Methods

A resting-state functional magnetic resonance imaging scan was collected from 131 young adults with a wide range of severity of subclinical delusional beliefs, including persecutory ideas. Because of evidence for a key role of the amygdala in fear and paranoia, resting-state functional connectivity of the amygdala was measured.

Results

Connectivity between the amygdala and early visual cortical areas, including striate cortex (V1), was found to be significantly greater in participants with high (n = 43) v. low (n = 44) numbers of delusional beliefs, particularly in those who showed persistence of those beliefs. Similarly, across the full sample, the number of and distress associated with delusional beliefs were positively correlated with the strength of amygdala-visual cortex connectivity. Moreover, further analyses revealed that these effects were driven by those who endorsed persecutory beliefs.

Conclusions

These findings are consistent with the hypothesis that aberrant assignments of threat to sensory stimuli may lead to the downstream development of delusional ideas. Taken together with prior findings of disrupted sensory-limbic coupling in psychosis, these results suggest that altered amygdala-visual cortex connectivity could represent a marker of psychosis-related pathophysiology across a continuum of symptom severity.

Keywords

AmygdalafMRIpersecutory ideationresting-state functional connectivitysubclinical delusionsvisual cortex
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 2 , January 2020 , pp. 273 - 283
Copyright
Copyright © Cambridge University Press 2019

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