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Impulsivity and neural correlates of response inhibition in schizophrenia

Published online by Cambridge University Press:  21 April 2010

A. Kaladjian ,
R. Jeanningros ,
J.-M. Azorin ,
J.-L. Anton  and
P. Mazzola-Pomietto
A. Kaladjian*
Affiliation:
Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS – Université de la Méditerranée, Marseille, France Pôle Universitaire de Psychiatrie Adulte, Hôpital Sainte Marguerite, Marseille, France
R. Jeanningros
Affiliation:
Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS – Université de la Méditerranée, Marseille, France
J.-M. Azorin
Affiliation:
Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS – Université de la Méditerranée, Marseille, France Pôle Universitaire de Psychiatrie Adulte, Hôpital Sainte Marguerite, Marseille, France
J.-L. Anton
Affiliation:
Centre d'Imagerie par Résonance Magnétique fonctionnelle, IFR 131, Marseille, France
P. Mazzola-Pomietto
Affiliation:
Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS – Université de la Méditerranée, Marseille, France
*
*Address for correspondence: A. Kaladjian, M.D., Ph.D., Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS – Université de la Méditerranée, 31, chemin Joseph Aiguier13402Marseillecedex 20, France (Email: [email protected])
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Abstract

Background

The clinical picture of schizophrenia is frequently worsened by manifestations of impulsivity. However, the neural correlates of impulsivity in this disorder are poorly known. Although impulsivity has been related to disturbances of the neural processes underlying response inhibition, no studies have yet examined the relationship between these processes and psychometric measures of impulsivity in schizophrenia. This was the aim of the current investigation.

Method

Event-related functional magnetic resonance imaging in conjunction with a Go/NoGo task was employed to probe the neural activity associated with response inhibition in 26 patients with schizophrenia and 30 healthy comparison subjects. All participants also completed the Barratt Impulsiveness Scale – version 11 (BIS-11). Voxel-wise regression analyses were used to examine the relationship between the BIS-11 score and brain activation during response inhibition in each group.

Results

Patients with schizophrenia were more impulsive than healthy subjects, as indicated by higher BIS-11 scores. Patients, but not healthy subjects, were found to display a positive correlation between these scores and cerebral activation associated with response inhibition. This correlation involves a unique cluster localized within the right ventrolateral prefrontal cortex (VLPFC), a key node of the brain network subserving response inhibition.

Conclusions

We evidenced in patients with schizophrenia that greater BIS-11 scores are associated with greater activation within the right VLPFC during response inhibition. This finding suggests that the efficiency of this brain region to process inhibitory control is reduced in the more impulsive patients.

Keywords

Barrattbrain activationfMRIimpulsivityresponse inhibitionschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 2 , February 2011 , pp. 291 - 299
Copyright
Copyright © Cambridge University Press 2010

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