Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-22T19:38:12.390Z Has data issue: false hasContentIssue false

How should DSM-V classify eating disorder not otherwise specified (EDNOS) presentations in women with lifetime anorexia or bulimia nervosa?

Published online by Cambridge University Press:  05 January 2010

K. T. Eddy*
Affiliation:
Harris Center, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
S. A. Swanson
Affiliation:
National Institute of Mental Health, Section on Developmental Genetic Epidemiology, Bethesda, MD, USA
R. D. Crosby
Affiliation:
Neuropsychiatric Research Institute, Fargo, ND, USA Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA
D. L. Franko
Affiliation:
Harris Center, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Counseling and Applied Educational Psychology, Northwestern University, Boston, MA, USA
S. Engel
Affiliation:
Neuropsychiatric Research Institute, Fargo, ND, USA Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA
D. B. Herzog
Affiliation:
Harris Center, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
*
*Address for correspondence: K. T. Eddy, Ph.D., Massachusetts General Hospital, Department of Psychiatry, 2 Longfellow Place, Ste 200, Boston, MA 02214, USA. (Email: [email protected])

Abstract

Objective

Anorexia nervosa (AN) and bulimia nervosa (BN) are marked by longitudinal symptom fluctuations. DSM-IV-TR does not address how to classify eating disorder (ED) presentations in individuals who no longer meet full criteria for these disorders. To consider this issue, we examined subthreshold presentations in women with initial diagnoses of AN and BN.

Method

A total of 246 women with AN or BN were followed for a median of 9 years; weekly symptom data were collected at frequent intervals using the Longitudinal Interval Follow-up Evaluation of Eating Disorders (LIFE-EAT-II). Outcomes were ED presentations that were subthreshold for ⩾3 months, including those narrowly missing full criteria for AN or BN, along with binge eating disorder (BED) and purging disorder.

Results

During follow-up, most women (77.6%) experienced a subthreshold presentation. Subthreshold presentation was related to intake diagnosis (Wald χ2=8.065, df=2, p=0.018). Individuals with AN most often developed subthreshold presentations resembling AN; those with BN were more likely to develop subthreshold BN. Purging disorder was experienced by half of those with BN and one-quarter of those with AN binge/purge type (ANBP); BED occurred in 20% with BN. Transition from AN or BN to most subthreshold types was associated with improved psychosocial functioning (p<0.001).

Conclusions

Subthreshold presentations in women with lifetime AN and BN were common, resembled the initial diagnosis, and were associated with modest improvements in psychosocial functioning. For most with lifetime AN and BN, subthreshold presentations seem to represent part of the course of illness and to fit within the original AN or BN diagnosis.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agras, WS, Crow, S, Mitchell, JE, Halmi, KA, Bryson, S (2009). A 4-year prospective study of eating disorder NOS compared with full eating disorder syndromes. International Journal of Eating Disorders 42, 565570.CrossRefGoogle ScholarPubMed
Anderluh, M, Tchanturia, K, Rabe-Heskith, S, Collier, D, Treasure, J (2009). Lifetime course of eating disorders: design and validity testing of a new strategy to define the eating disorders phenotype. Psychological Medicine 39, 105114.CrossRefGoogle ScholarPubMed
APA (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn, text revision. American Psychiatric Association: Washington, DC.Google Scholar
Eddy, KT, Dorer, DJ, Franko, DL, Tahilani, K, Thompson-Brenner, H, Herzog, DB (2008). Longitudinal diagnostic crossover of anorexia and bulimia nervosa: implications for DSM-V. American Journal of Psychiatry 165, 245250.CrossRefGoogle ScholarPubMed
Fairburn, CG, Bohn, K (2005). Eating disorder NOS (EDNOS): an example of the troublesome ‘not otherwise specified’ (NOS) category in DSM-IV. Behaviour Research and Therapy 43, 691701.CrossRefGoogle ScholarPubMed
Herzog, DB, Dorer, DJ, Keel, PK, Selwyn, SE, Ekeblad, ER, Flores, AT, Greenwood, DN, Burwell, RA, Keller, MB (1999). Recovery and relapse in anorexia and bulimia nervosa: a 7.5-year follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry 38, 829837.CrossRefGoogle ScholarPubMed
Herzog, DB, Hopkins, JD, Burns, CD (1993). A follow-up study of 33 subdiagnostic eating disordered women. International Journal of Eating Disorders 14, 261267.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Keel, PK (2007). Purging disorder: subthreshold variant or full-threshold eating disorder? International Journal of Eating Disorders 40, S89S94.CrossRefGoogle ScholarPubMed
Keel, PK, Dorer, DJ, Franko, DL, Jackson, SC, Herzog, DB (2005). Postremission predictors of relapse in women with eating disorders. American Journal of Psychiatry 162, 22632268.CrossRefGoogle ScholarPubMed
Keel, PK, Striegel-Moore, (2009). The validity and clinical utility of purging disorder. International Journal of Eating Disorders 42, 706719.CrossRefGoogle ScholarPubMed
Keller, MB, Lavori, PW, Friedman, B, Nielsen, E, Endicott, J, McDonald-Scott, P, Andreasen, NC (1987). The Longitudinal Interval Follow-Up Evaluation: a comprehensive interview for assessing outcome in prospective longitudinal studies. Archives of General Psychiatry 44, 540548.CrossRefGoogle ScholarPubMed
Leon, AC, Solomon, DA, Mueller, TI, Endicott, J, Posternak, M, Judd, LL, Schlettler, PJ, Akiskal, HS, Keller, MB (2000). A brief assessment of psychosocial functioning of subjects with bipolar I disorder: the LIFE-RIFT. Longitudinal Interval Follow-Up Evaluation Range of Impaired Functioning Tool. Journal of Nervous and Mental Disease 188, 805812.CrossRefGoogle ScholarPubMed
Leon, AC, Solomon, DA, Mueller, TI, Turvey, CL, Endicott, J, Keller, MB (1999). The Range of Impaired Functioning Tool (LIFE-RIFT): a brief measure of functional impairment. Psychological Medicine 29, 869878.CrossRefGoogle ScholarPubMed
Milos, G, Spindler, A, Schnyder, U, Fairburn, CG (2005). Instability of eating disorder diagnoses: prospective study. British Journal of Psychiatry 187, 573578.CrossRefGoogle ScholarPubMed
R Development Core Team (2007). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria (www.R-project.org).Google Scholar
Thomas, JJ, Vartanian, LR, Brownell, KD (2009). The relationship between eating disorder not otherwise specified (EDNOS) and officially recognized eating disorders: meta-analysis and implications for DSM. Psychological Bulletin 135, 407433.CrossRefGoogle Scholar
Tozzi, F, Thornton, LM, Klump, KL, Fichter, MM, Halmi, KA, Kaplan, AS, Strober, M, Woodside, DB, Crow, S, Mitchell, JE, Rotondo, A, Mauri, M, Cassano, G, Keel, P, Plotnikov, KH, Pollice, C, Lilenfeld, LR, Berrettini, WH, Bulik, CM, Kaye, WH (2005). Symptom fluctuation in eating disorder: correlates of diagnostic crossover. American Journal of Psychiatry 162, 732740.CrossRefGoogle ScholarPubMed