Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-23T00:45:20.353Z Has data issue: false hasContentIssue false
  • English
  • Français

HLA antigens and manic-depressive disorders: further evidence of an association

Published online by Cambridge University Press:  09 July 2009

Robert W. Shapiro ,
Lars P. Ryder ,
Arne Svejgaard  and
Ole J. Rafaelsen
Robert W. Shapiro*
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
Lars P. Ryder
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
Arne Svejgaard
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
Ole J. Rafaelsen
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
*
1Address for correspondence: Dr Robert W.Shapiro, Massachusett Mental Health Center, Boston Psycho pathic Hospital, 72–76 Fenwood Road, Boston, Mass. 02115, U.S.A.
Get access Rights & Permissions [Opens in a new window]

Synopsis

One hundred and seven unrelated Danish patients considered to be manic-depressive according to strict diagnostic, symptomatic and course criteria were typed for antigens of the HLA system, the major histocompatibility system in man. Preliminary results from the first 47 patients had previously been reported to suggest a positive association between manic-depressive disorders and HLA-A3, HLA-B7, and HLA-Bw16 and a negative association between such disorders and HLA-B8. Results from the extended series provide confirmatory evidence that there is a positive association between manic-depressive disorders and HLA-Bw16 and also strongly suggest a positive association between HLA-B7 and such disorders. HLA typing may prove to be a useful way of identifying sub-groups of manic-depressive patients for other biological studies. The associations described provide a potential lead for formulating hypotheses about the nature of the biological mechanisms which predispose to manic-depressive disorders.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 3 , August 1977 , pp. 387 - 396
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bennahum, D. A., Troup, G. M., Rada, R. T., Kellner, R. & Kyner, T. (1977). HLA antigens in schizophrenic and manic depressive mental disorders. Clinical Research 25 (2), 114A.Google Scholar
Kissmeyer-Nielsen, F. & Kjerbye, K. E. (1967). Lymphocytonic microtechnique – purification of lymphocytes by flotation. Histocompatibility Testing (ed. Curtoni, E. S., Mattiuz, P. L. and Tosi, R. M.), pp. 381–383. Williams and Wilkins: Baltimore.Google Scholar
Rafaelsen, O. J. (1974). Manic-depressive psychosis or manic-melancholic mode. Danish Medical Bulletin 21, 81–87.Google ScholarPubMed
Rafaelsen, O. J. (1976). Biochemical theories of manic-melancholic disorders, In Monamine Oxidase and its Inhibition, CIBA Foundation Symposium (ed. Knight, J. & Wolstenholme, G. E. W.), pp. 372–378. Excerpta Medica: Amsterdam.Google Scholar
Shapiro, R. & Rafaelsen, O. J. (in preparation). A Multiaxial Classification of Affective Disorders for research purposes (MULTI-CLAD).Google Scholar
Shapiro, R. W., Bock, E., Rafaelsen, O. J., Ryder, L. P. & Svejgaard, A. (1976). Histocompatibility antigens and manic-depressive disorders. Archives of General Psychiatry 33, 823–825.CrossRefGoogle ScholarPubMed
Shapiro, R. W., Rafaelsen, O. J., Ryder, L. P., Svejgaard, A. & Sørensen, H. (1977). ABO blood groups in unipolar and bipolar manic-depressive patients. The American Journal of Psychiatry 134, 197–200.Google ScholarPubMed
Staub Nielsen, L., Jersild, C., Ryder, L. P. & Svejgaard, A. (1975). HLA antigen, gene, and haplotype frequencies in Denmark. Tissue Antigens 6, 70.CrossRefGoogle ScholarPubMed
Stember, R. H. & Fieve, R. R. (1976). Histocompatibility complex in affective disorders.Paper read at the annual meeting of the American Psychiatric AssociationMiami, May 1976.Google Scholar
Svejgaard, A. & Ryder, L. P. (1976). Hypothesis – interaction of HLA molecules with non-immunological ligands as an explanation of HLA and disease associations. Lancet ii, 547–549.CrossRefGoogle Scholar
Svejgaard, A., Hauge, M., Jersild, C., Platz, P., Ryder, L. P., Staub Nielsen, L. & Thomsen, M. (1975). The HLA System. An Introductory Survey. S. Karger: Basel.Google ScholarPubMed