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Growth hormone response to growth hormone releasing hormone in non-delusional and delusional depression and healthy controls

Published online by Cambridge University Press:  09 July 2009

F. Contreras ,
M. A. Navarro ,
J. M. Menchon ,
P. Rosel ,
J. Serrallonga ,
F. Perez-Arnau ,
M. Urretavizcaya  and
J. Vallejo
F. Contreras*
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
M. A. Navarro
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
J. M. Menchon
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
P. Rosel
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
J. Serrallonga
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
F. Perez-Arnau
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
M. Urretavizcaya
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
J. Vallejo
Affiliation:
Department of Psychiatry and the Hormone Unit, Hospital de Bellvitge, School of Medicine, Barcelona, Spain
*
1Address for correspondence: Drs F. Contreras and J. Vallejo, Department of Psychiatry, Hospital de Bellvitge, Feixa Llarga, s/n, 08907-L'Hospitalet de Llobregat, Barcelona, Spain.
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Synopsis

Growth hormone (GH) responses to growth hormone releasing hormone (GHRH) of 53 in-patients meeting DSM-III-R criteria for major depressive episode with melancholia (24 non-delusional and 23 delusional depression) were compared with those of 19 healthy controls. No significant differences in basal GH were found between the control and either the non-delusional or the delusional groups. The whole group of depressed patients showed a significantly lower response than the control patients at all points of the GH response to GHRH curve as well as a lower area under curve. When the three groups (control, delusional and non-delusional depressed) were compared, it was found that only the non-delusional depressed patients had a significantly lower area under curve and lower values at +60, +90 and +120 min than the controls. The only significant difference between the two groups of depressed patients was that the delusional group showed a delayed appearance of the maximum response peak and a more prolonged response.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 2 , March 1996 , pp. 301 - 307
Copyright
Copyright © Cambridge University Press 1996

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References

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