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Growth hormone and physiological responses to clonidine in depression

Published online by Cambridge University Press:  09 July 2009

Cornelius L. E. Katona ,
David Healy ,
Eugene S. Paykel ,
Andreas E. Theodorou ,
Kevin M. Lawrence ,
Andrew Whitehouse ,
Bill White  and
Roger W. Horton
Cornelius L. E. Katona*
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
David Healy
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
Eugene S. Paykel
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
Andreas E. Theodorou
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
Kevin M. Lawrence
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
Andrew Whitehouse
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
Bill White
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
Roger W. Horton
Affiliation:
Department of Psychiatry, University College and Middlesex School of Medicine, London
*
1Address for correspondence: Professor Cornelius L. E. Katona, Department of Psychiatry, UCMSM, Wolfson Building, Middlesex Hospital, London WIN 8AA.
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Synopsis

Clonidine (1·3 μg/kg) was administered to 62 control and 55 depressed patients free of psychoactive drugs for at least 7 days and fasted overnight. Growth hormone (GH), pulse, blood pressure and sedation were measured every 15 min for 1 h before and 2 h after clonidine infusion.

GH response did not differ significantly between control and depressed subjects overall or when divided by sex. The systolic hypotensive and sedative responses were blunted in depressed subjects compared with controls; these effects appeared to be secondary to residual antidepressant drugs since the differences were only significant for those depressed subjects with short drug-free intervals.

No differences between depressed subjects and controls were seen in diastolic hypotensive or bradycardic responses and no differences in GH, cardiovascular or sedative responses were found between endogenous and non-endogenous depressed subjects.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 1 , February 1993 , pp. 57 - 63
Copyright
Copyright © Cambridge University Press 1993

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