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Genetics and developmental stability: an integrative conjecture on aetiology and neurobiology of schizophrenia

Published online by Cambridge University Press:  09 July 2009

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Copyright © Cambridge University Press 1992

References

Adams, M. S. & Niswander, J. D. (1967). Developmental ‘noise’ and a congenital malformation. Genetical Research 10, 313317.CrossRefGoogle Scholar
Andreasen, N. C., Dennert, J. W., Olson, S. A., & Damasio, A. R. (1982). Hemispheric asymmetrics and schizophrenia. American Journal of Psychiatry 139, 427430.Google Scholar
Bader, R. (1965). Fluctuating asymmetry in the dentition of the house mouse. Growth 29, 291300.Google ScholarPubMed
Bailit, H. L., Workman, P. L., Niswander, J. D. & MacLean, C. J. (1970). Dental asymmetry as an indicator of genetic and environmental conditions in human populations. Human Biology 42, 626638.Google ScholarPubMed
Bassett, A. S., McGilliray, B. C., Jones, B. D. & Pantzar, J. T. (1988). Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet i, 799801.CrossRefGoogle Scholar
Bleuler, M. (1974). The longterm cause of the schizophrenic psychoses. Psychological Medicine 4, 244254.CrossRefGoogle Scholar
Bradshaw, J. L. & Nettleton, N. C. (1981). The nature of hemispheric specialization in man. Behavior and Brain Sciences 4, 5193.CrossRefGoogle Scholar
Brown, R., Colter, N., Corsellis, J. A. N., Crow, T. J., Frith, C. D., Jagoe, X. X. & Johnstone, E. C. (1984). Post mortem evidence of structural brain changes in schizophrenia. Archives of General Psychiatry 43, 3642.CrossRefGoogle Scholar
Cannon, T. D., Mednick, S. A. & Parnas, J. (1989). Genetic and perinatal determinants of structural brain deficits in schizophrenia. Archives of General Psychiatry 46, 883889.CrossRefGoogle ScholarPubMed
Cavalli-Sforza, L. L. & Bodmer, W. (1971). The Genetics of Human Populations. W. H. Freeman: San Francisco.Google Scholar
Coffman, J. A., Andreasen, N. C. & Nasrallah, H. A. (1984). Left hemispheric density deficits in chronic schizophrenia. Biological Psychology 19, 12371247.Google ScholarPubMed
Colbourn, C. J. & Lishman, W. A. (1979). Lateralization of function and psychotic illness: a left hemisphere deficit? In Hemisphere Asymmetries of Function in Psychopathology (ed. Gruzelier, J. H. and Flor-Henry, P.), pp. 539629. Elsevier: Amsterdam.Google Scholar
Connolly, J. F., Gruzelier, J. H. & Manchanda, R. (1983 a). Electrocortical and perceptual asymmetries in schizophrenia. In laterality and Psychopathology (ed. Flor-Henry, P. and Gruzelier, J. H.), pp. 491516. Elsevier: Amsterdam.Google Scholar
Connolly, J. F., Gruzelier, J. H., Manchanda, R. & Hirsch, S. R. (1983 b). Visual evoked potentials in schizophrenia: intensity effects and hemispheric asymmetry. British Journal of Psychiatry 142, 152155.CrossRefGoogle ScholarPubMed
Connolly, J. F., Manchanda, R., Gruzelier, J. H. & Hirsch, S. R. (1985). Pathway and hemispheric differences in the event related potential (ERP) to monaural stimulation: a comparison of schizophrenic patients with normal controls. Biological Psychiatry 20, 293303.CrossRefGoogle ScholarPubMed
Dimond, S. J. & Beamont, J. G. (1973). Differences in vigilance performance of the right and left hemispheres. Cortex 9, 259265.CrossRefGoogle ScholarPubMed
Dobzhansky, T. (1962). Mankind Evolving: The Evolution of the Human Species. Yale University Press: New Haven.Google Scholar
Farde, L., Wiesel, F. A., Stone-Elander, S., Hallidin, C., Nordstom, A. C., Hall, H. & Sedvall, G. (1990). D2Dopamine receptors in neuroleptic-naive schizophrenic patients: position emission romography study with [11C]raclopride. Archives of General Psychiatry 47, 213219.CrossRefGoogle Scholar
Flor-Henry, P. (1979). Laterality, shifts of cerebral dominance, sinistrality, and psychosis. In Hemisphere Asymmetries of Function in Psychopathology (ed. Gruzelier, J. H., and Flor-Henry, P.), pp. 320. Elsevier/North Holland: Amsterdam.Google Scholar
Galaburda, A. M., LeMay, M., Kemper, T. L. & Geschwind, N. (1978). Right left asymmetries in the brain. Science 199, 852856.CrossRefGoogle ScholarPubMed
Geschwind, N. & Galaburda, A. M. (1987). Cerebral Lateralization: Biological Mechanisms, Associations and Pathology. MIT Press: Cambridge.Google Scholar
Glass, A. (1984). Individual differences in hemispheric specialization. Nato Advanced Science Institute Series, vol. 130. Pleam: New York.Google Scholar
Golden, C. J., Graber, B., Coffman, J., Berg, R. A., Newlin, D. B., Bloch, S. & Brogan, D. (1980 a). Brain density deficits in chronic schizophrenia. Psychiatry Research 3, 179184.CrossRefGoogle ScholarPubMed
Golden, C. J., Moses, J. A. Jr., Zelazowski, R., Graber, D., Zatz, L. M., Horvath, T. B. & Berger, P. A. (1980 b). Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics. Archives of General Psychiatry 37, 619623.CrossRefGoogle ScholarPubMed
Golden, C. J., Graber, B., Coffman, J., Berg, R. A., Newlin, D. B. & Bloch, S. (1981). Structural brain deficits in schizophrenia: identification by computed tomographic scan density measurements. Archives of General Psychiatry 38, 10141017.CrossRefGoogle ScholarPubMed
Gottesman, I. I. & Bertelson, A. (1989). Confirming unexpressed genotypes for schizophrenia. Archives of General Psychiatry 46, 867872.CrossRefGoogle ScholarPubMed
Gottesman, I. I. & Shields, J. (1967). A polygenic theory of schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 58, 199205.CrossRefGoogle ScholarPubMed
Gottesman, I. I. & Shields, J. (1972). Schizophrenia and Genetics: A Twin Study Vantage Point. Academic Press: New York.Google Scholar
Gottesman, I. I., Shields, J. & Hanson, D. (1982). Schizophrenia: The Epigenetic Puzzle. Cambridge University Press: New York.Google Scholar
Gruzelier, J. (1983). A critical assessment and interpretation of lateral asymmetries in schizophrenia. In Hemisyndromes: Psychobiology, Neurology, and Psychiatry (ed. Myslobodsky, M.), pp. 265320. Academic Press: New York.Google Scholar
Gruzelier, J. H. & Flor-Henry, P. (eds) (1979). Hemisphere Asymmetries of Function in Psychopathology. Elsevier: Amsterdam.Google Scholar
Gur, R. C. & Reivich, M. (1980). Cognitive task effects on hemispheric blood flow in humans: evidence for individual differences in hemispheric activations. Brain and Language 9, 792.CrossRefGoogle Scholar
Gur, R. E., Skolnick, B. E., Gur, R. C., Caroff, S., Rieger, W., Obrist, W. D., Younkin, D. & Reivich, M. (1983). Brain function in psychiatric disorder. I. Regional cerebral blood flow in medicated schizophrenics. Archives of General Psychiatry 40, 12501254.CrossRefGoogle ScholarPubMed
Harnad, S., Doty, R. W., Goldstein, L., Jaynes, J. & Krauthamer, G. (eds) (1977). Lateralization in the Nervous System. Academic Press: New York.Google Scholar
Hier, D. B., LeMay, M. & Rosenberger, P. B. (1978). Perto-VP: developmental dyslexia. Evidence for a subgroup with a reversal of cerebral asymmetry. Archives of Neurology 35, 9092.CrossRefGoogle ScholarPubMed
Hier, D. B., LeMay, M. & Rosenberger, P. B. (1979). Autism and unfavorable left-right asymmetries of the brain. Journal of Autism Development and Discord 9, 153159.CrossRefGoogle ScholarPubMed
Karn, M. N. & Penrose, L. S. (1951). Birthweight and gestation time in relation to maternal age, parity, and infant survival. Annals of Eugenics 15, 206233.Google Scholar
Kaufmann, C. A., DeLisi, L., Lehner, T. & Gilliam, T. C. (1989). Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5Q. Schizophrenia Bulletin 15, 441452.CrossRefGoogle ScholarPubMed
Kendell, R. E. & Kemp, I. W. (1989). Maternal influenza in the etiology of schizophrenia. Archives of General Psychiatry 46, 878882.CrossRefGoogle ScholarPubMed
Kennedy, J. L., Giuffra, L. A., Moises, H. W., Cavalli-Sforza, L. L., Pakstis, A. J., Kidd, J. R., Castiglione, C. M., Sjogren, B., Wetterberg, L. & Kidd, K. K. (1988). Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336, 167170.CrossRefGoogle Scholar
Lander, E. S. & Botstein, D. (1987). Homozygosity mapping: a way to map human recessive traits with DNA from inbred children. Science 236, 15671570.CrossRefGoogle ScholarPubMed
Largern, J. W. Jr., Calderon, M. & Smith, R. C. (1983). Asymmetries in the densities of white and grey matter in the brains of schizophrenic patients. American Journal of Psychiatry 140, 10601062.Google Scholar
Leary, R. F. & Allendorf, F. W. (1989). Fluctuating asymmetry as an indicator of stress: implications for conservation biology. Trends in Ecology and Evolution 4, 213217.CrossRefGoogle ScholarPubMed
Leary, F. R., Allendorf, F. W. & Knudsen, K. L. (1983). Developmental stability and enzyme heterozygosity in rainbrow trout. Nature 301, 7172.CrossRefGoogle ScholarPubMed
Leary, F. R., Allendorf, F. W. & Knudsen, K. L. (1984). Superior developmental stability of heterozygotes at enzyme loci in salmonid fishes. American Naturalist 124, 540551.CrossRefGoogle Scholar
Lerner, I. M. (1954). Genetic Homeostasis. John Wiley & Sons: New York.Google Scholar
Lerner, J., Naschon, I. & Carmon, A. (1977). Response of paranoid and nonparanoid schizophrenics in a dichotic listening task. Journal of Nervous and Mental Disease 164, 247252.CrossRefGoogle Scholar
Levy, J. (1977). The origins of lateral asymmetry. In Lateralization in the Nervous System (ed. Harnad, S., Dotz, R. W., Goldstein, L.Jaynes, J. and Krauthamer, G.), pp. 195209. Academic Press: New York.CrossRefGoogle Scholar
Lishman, W. A. & McMeekan, E. R. L. (1976). Hand preference patterns in psychiatric patients. British Journal of Psychiatry 129, 158166.CrossRefGoogle ScholarPubMed
Lishman, W. A., Toone, B. K., Colburn, C. J., McMeekan, E. R. L. & Mance, R. M. (1978). Dichotic listening in psychotic patients. British Journal of Psychiatry 132, 333341.CrossRefGoogle ScholarPubMed
Livshitz, G. & Kobylianski, E. (1987). Dermatoglyphic traits as possible markers of developmental processes in humans. American Journal of Medical Genetics 26, 111112.CrossRefGoogle Scholar
Luchins, D. J., Weinberger, D. R. & Wyatt, R. J. (1979). Schizophrenia: evidence of a subgroup with reversed cerebral asymmetry. Archives of General Psychiatry 36, 13091311.CrossRefGoogle ScholarPubMed
Luchins, D. J., Weinberger, D. R. & Wyatt, R. J. (1982). Schizophrenia and cerebral asymmetry detected by computer tomography. American Journal of Psychiatry 139, 753757.Google Scholar
McGue, M., Gottesman, I. I. & Rao, D. E. (1983). The transmission of schizophrenia under a multifactorial threshold, model. American Journal of Human Genetics 35, 1161.Google Scholar
McGue, M., Gottesman, I. I. & Rao, D. E. (1985). Resolving genetic models for the transmission of schizophrenia. Genetic Epidemiology 2, 99110.CrossRefGoogle ScholarPubMed
Markow, T. & Gottesman, I. I. (1989 a). Fluctuating dermatoglyphic asymmetry in twins and singletons. Hereditas 110, 211215.CrossRefGoogle ScholarPubMed
Markow, T. & Gottesman, I. I. (1989 b). Dermatoglyphic fluctuating asymmetry in psychotic twins. Psychiatry Research 29, 3743.CrossRefGoogle ScholarPubMed
Markow, T. & Wandler, K. (1986). Fluctuating dermatoglyphic asymmetry and the genetics of liability to schizophrenia. Psychiatry Research 19, 323328.CrossRefGoogle ScholarPubMed
Marsh, L. (1986). Postmortem evidence of structural brain changes in schizophrenia. Archives of General Psychiatry 43, 3642.Google Scholar
Martin, N. G., Jinks, J. L., Berry, H. S. & Loesh, D. (1982). A genetic analysis of directly and asymmetry in finger ridge counts. Heredity 48, 393405.CrossRefGoogle Scholar
Meehl, P. (1989). Schizotaxia revisited. Archives of General Psychiatry 46, 935944.CrossRefGoogle ScholarPubMed
Merrin, E. L. (1981). Schizophrenia and brain asymmetry: an evaluation of evidence for dominant lobe dysfunction. Journal of Nervous and Mental Disease 169, 405416.CrossRefGoogle ScholarPubMed
Mitton, J. B. & Grant, M. C. (1984). Associations among protein heterozygosity, growth rate, and developmental homeostasis. Annual Review of Ecology and Systematics 14, 479499.CrossRefGoogle Scholar
Mitton, J. B. & Koehn, R. K. (1985). Shell shape variation in the blue mussel, Mytilus edulis L. and its association with enzyme heterozygosity. Journal of Experimental Marine Biology and Ecology 90, 7380.CrossRefGoogle Scholar
Morgan, M. (1977). Embryology and inheritance of assymetry. In Lateralization in the Nervous System (ed. Harnad, S., Dotz, R. W., Goldstein, L., Jaynes, J. and Krauthamer, G.), pp. 173194. Academic Press: New York.CrossRefGoogle Scholar
Morton, N. E. & MacLean, C. J. (1974). Analysis of family resemblance. III Complex segregation analysis of quantitative traits. American Journal of Human Genetics 26, 489503.Google Scholar
Murray, R. M., Lewis, S. W., Owen, M. J. & Forester, A. (1988). The neurodevelopmental origins of dementia praecox. Schizophrenia, the Major Issues. (ed. Bebbington, P. and McGuffin, P.), pp. 91106. Heinemann: Oxford.Google Scholar
Myslobodsky, M. S. (1983). Hemisyndromes: Psychobiology, Neurology, Psychiatry. Academic Press: New York.Google Scholar
Myslobodsky, M. S., Mintz, M. & Tomer, R. (1983). Neuroleptic effects and the site of abnormality in schizophrenia. In Hemisyndromes: Psychobiology, Neurology and Psychiatry (ed. Myslobodsky, M. S.), pp. 347388. Academic Press: New York.Google Scholar
Neuchterlein, K. H. (1983). Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology 92, 428.CrossRefGoogle Scholar
Palmer, R. & Strobeck, C. (1986). Fluctuating asymmetry; measurement, analysis, patterns. Annual Review of Ecology and Systematics 17, 391421.CrossRefGoogle Scholar
Reeve, E. C. R. (1960). Some genetic tests on asymmetry of sternopleural chaetae number in Drosophila. Genetical Research 1, 151172.CrossRefGoogle Scholar
Reynolds, G. P. (1983). Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305, 527530.CrossRefGoogle ScholarPubMed
Reynolds, G. P., Czudek, C., Browej, N. & Seeman, P. (1987). Dopamine receptor asymmetry in schizophrenia. Lancet i, 17101716.Google Scholar
Ricker, J. P., Boring, R. H., Harris, A. E. & Markow, T. (1989). Fluctuating dermatoglyphic asymmetry and its association with positive and negative symptoms in schizophrenia. Schizophrenia Research 2, 73.CrossRefGoogle Scholar
Risch, N. (1990). Linkage strategies for genetically complex traits. I. Multilocus models. American Journal of Human Genetics 46, 222228.Google ScholarPubMed
Rosenberger, P. B., Hier, D. B. (1980). Cerebral asymmetry and verbal intellectual deficits. Annals of Neurology 8, 300304.CrossRefGoogle ScholarPubMed
Schwartz, S. & Kirsner, K. (1984). Can group differences in hemispheric asymmetry be inferred from behavioral laterality indices? Brain and Cognition 3, 5770.CrossRefGoogle ScholarPubMed
Schweitzer, L., Becker, E. & Welsh, H. (1978). Abnormalities of cerebral lateralization in schizophrenic patients. Archives of General Psychiatry 35, 982985.CrossRefGoogle Scholar
Sherrington, R., Brynjolfsson, J., Petursson, H., Potter, M., Dudleston, K., Barraclough, B., Wasmuth, J., Dobbs, M. & Gurling, M. (1988). Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164167.CrossRefGoogle ScholarPubMed
Slater, E. (1983). Psychotic and Neurotic Illness in Twins. Medical Research Council Special Reports Series No. 278. Her Majesty's Stationery Office: London.Google Scholar
Smith, B. H., Garn, S. & Cole, P. M. (1983). Problems of sampling and inference in the study of fluctuating dental asymmetry. American Journal of Physical Anthropology 58, 281289.CrossRefGoogle Scholar
Soule, M. E. & Couzin-Roudy, J. (1982). Allometric variation. 2. Developmental instability of extreme phenotypes. American Naturalist 120, 765786CrossRefGoogle Scholar
St. Clair, D., Blackwood, D., Muir, W., Baillie, D., Hubbard, A., Wright, A. & Evans, H. J. (1989). No linking of chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature 339, 305309.CrossRefGoogle Scholar
Taylor, P. J., Dalton, R., Fleminger, J. J. & Lishman, W. A. (1982). Differences in two studies of hand preference in psychiatric patients. British Journal of Psychiatry 140, 167173.CrossRefGoogle ScholarPubMed
Tebb, G. & Thoday, J. M. (1954). Stability in development and relational balance of X-chromosomes in D. melanogaster. Nature 174, 1109.CrossRefGoogle Scholar
Thoday, J. M. (1961). Location of polygenes. Nature 191, 368370.CrossRefGoogle Scholar
Townsend, G. C. & Brown, T. (1980). Dental asymmetry in Australian aboriginals. Human Biology 52, 661673.Google ScholarPubMed
Van Valen, L. (1962). A study of fluctuating asymmetry. Evolution 16, 125–000.CrossRefGoogle Scholar
Vogel, F. & Motulsky, A. G. (1988). Human Genetics, Problems and Approaches. Springer-Verlag: New York.Google Scholar
Vrijenhoek, R. C. & Lerman, S. (1982). Heterozygosity and developmental stability under sexual and asexual breeding systems. Evolution 36, 768776.CrossRefGoogle ScholarPubMed
Waddington, C. H. (1957). The Strategy of the Genes. Macmillan: New York.Google Scholar
Waldrop, M. & Halvoroson, C. (1971). Minor physical anomalies: Their incidence and relation to behavior in a normal and deviant sample. In Readings in Development and Relationships (ed. Smart, R. Jr. and Smart, M.), Macmillan: New York.Google Scholar
Weinberger, D. R. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660669.CrossRefGoogle ScholarPubMed
Weinberger, D. R. & Wyatt, R. J. (1982). Brain morphology in schizophrenia: In vivo studies. In Schizophrenia as a Brain Disease (ed. Henn, F. A. and Nasrallah, H. A.), pp. 148175. Oxford University Press: New York.Google Scholar
Woolf, C. M. & Gianas, A. (1976). Congenital cleft lip and fluctuating dermatoglyphic asymmetry. American Journal of Human Genetics 28, 400403.Google ScholarPubMed
Woolf, C. M. & Gianas, A. (1977). A study of fluctuating dermatoglyphic asymmetry in the sibs and parents of cleft lip propositi. American Journal of Human Genetics 28, 503507.Google Scholar