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Gene–environment interplay between parent–child relationship problems and externalizing disorders in adolescence and young adulthood

Published online by Cambridge University Press:  23 June 2014

D. R. Samek ,
B. M. Hicks ,
M. A. Keyes ,
J. Bailey ,
M. McGue  and
W. G. Iacono
D. R. Samek*
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
B. M. Hicks
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
M. A. Keyes
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
J. Bailey
Affiliation:
Social Development Research Group, University of Washington, Seattle, WA, USA
M. McGue
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
W. G. Iacono
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
*
*Address for correspondence: D. R. Samek, Ph.D., N218 Elliott Hall, 75 E River Road, Minneapolis, MN 55455, USA. (Email: [email protected])
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Abstract

Background

Previous studies have shown that genetic risk for externalizing (EXT) disorders is greater in the context of adverse family environments during adolescence, but it is unclear whether these effects are long lasting. The current study evaluated developmental changes in gene–environment interplay in the concurrent and prospective associations between parent–child relationship problems and EXT at ages 18 and 25 years.

Method

The sample included 1382 twin pairs (48% male) from the Minnesota Twin Family Study, participating in assessments at ages 18 years (mean = 17.8, s.d. = 0.69 years) and 25 years (mean = 25.0, s.d. = 0.90 years). Perceptions of parent–child relationship problems were assessed using questionnaires. Structured interviews were used to assess symptoms of adult antisocial behavior and nicotine, alcohol and illicit drug dependence.

Results

We detected a gene–environment interaction at age 18 years, such that the genetic influence on EXT was greater in the context of more parent–child relationship problems. This moderation effect was not present at age 25 years, nor did parent-relationship problems at age 18 years moderate genetic influence on EXT at age 25 years. Rather, common genetic influences accounted for this longitudinal association.

Conclusions

Gene–environment interaction evident in the relationship between adolescent parent–child relationship problems and EXT is both proximal and developmentally limited. Common genetic influence, rather than a gene–environment interaction, accounts for the long-term association between parent–child relationship problems at age 18 years and EXT at age 25 years. These results are consistent with a relatively pervasive importance of gene–environmental correlation in the transition from late adolescence to young adulthood.

Keywords

Adolescenceexternalizing behaviorsgene–environment correlationgene–environment interactionparent–child relationship quality
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 2 , January 2015 , pp. 333 - 344
Copyright
Copyright © Cambridge University Press 2014 

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References

Agrawal, A, Balasubramanian, S, Smith, EK, Madden, PA, Bucholz, KK, Heath, AC, Lynskey, MT (2010). Peer substance involvement modifies genetic influences on regular substance involvement in young women. Addiction 105, 1844–1853.Google Scholar
Amato, PR (1994). Father–child relations, mother–child relations, and offspring psychological well-being in early adulthood. Journal of Marriage and the Family 56, 1031–1042.CrossRefGoogle Scholar
Bailey, JA, Hill, KG, Meacham, MC, Young, SE, Hawkins, JD (2011). Strategies for characterizing complex phenotypes and environments: general and specific family environmental predictors of young adult tobacco dependence, alcohol use disorder, and co-occurring problems. Drug and Alcohol Dependence 118, 444–451.Google Scholar
Burt, SA, McGue, M, Krueger, RF, Iacono, WG (2005). How are parent–child conflict and childhood externalizing symptoms related over time? Results, from a genetically informative cross-lagged study. Development and Psychopathology 17, 145–165.Google Scholar
Button, TM, Lau, JY, Maughan, B, Eley, TC (2008). Parental punitive discipline, negative life events and gene–environment interplay in the development of externalizing behavior. Psychological Medicine 38, 29–39.CrossRefGoogle ScholarPubMed
Cadoret, RJ, Yates, WR, Troughton, E, Woodworth, G, Stewart, MA (1995). Genetic–environmental interaction in the genesis of aggressivity and conduct disorders. Archives of General Psychiatry 52, 916–924.Google Scholar
Crook, T, Raskin, A, Eliot, J (1981). Parent–child relationships and adult depression. Child Development 52, 950–957.CrossRefGoogle ScholarPubMed
Dick, DM (2011). Gene–environment interaction in psychological traits and disorders. Annual Review of Clinical Psychology 7, 383–409.Google Scholar
Dick, DM, Viken, R, Purcell, S, Kaprio, J, Pulkkinen, L, Rose, RJ (2007). Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking. Journal of Abnormal Psychology 116, 213–218.Google Scholar
Elkins, IJ, McGue, M, Iacono, WG (1997). Genetic and environmental influences on parent–son relationships: evidence for increasing genetic influence during adolescence. Developmental Psychology 33, 351–363.Google Scholar
Enders, CK, Bandalos, DL (2001). The relative performance of full information maximum likelihood estimation for missing data in structural equation models. Structural Equation Modeling – A Multidisciplinary Journal 8, 430–457.Google Scholar
Epstein, M, Hill, KG, Bailey, JA, Hawkins, JD (2013). The effect of general and drug-specific family environments on comorbid and drug-specific problem behavior: a longitudinal examination. Developmental Psychology 49, 1151–1164.Google Scholar
Feinberg, ME, Button, TM, Neiderhiser, JM, Reiss, D, Hetherington, EM (2007). Parenting and adolescent antisocial behavior and depression: evidence of genotype x parenting environment interaction. Archives of General Psychiatry 64, 457–465.Google Scholar
Haberstick, BC, Zeiger, JS, Corley, RP, Hopfer, CJ, Stallings, MC, Rhee, SH, Hewitt, JK (2011). Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use. Addiction 106, 215–224.Google Scholar
Hicks, BM, DiRago, AC, Iacono, WG, McGue, M (2009 a). Gene–environment interplay in internalizing disorders: consistent findings across six environmental risk factors. Journal of Child Psychology and Psychiatry 50, 1309–1317.Google Scholar
Hicks, BM, Foster, KT, Iacono, WG, McGue, M (2013). Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring. JAMA Psychiatry 70, 1076–1083.Google Scholar
Hicks, BM, South, SC, Dirago, AC, Iacono, WG, McGue, M (2009 b). Environmental adversity and increasing genetic risk for externalizing disorders. Archives of General Psychiatry 66, 640–648.CrossRefGoogle ScholarPubMed
Iacono, WG, Carlson, SR, Taylor, J, Elkins, IJ, McGue, M (1999). Behavioral disinhibition and the development of substance-use disorders: findings from the Minnesota Twin Family Study. Developmental Psychopathology 11, 869–900.Google Scholar
Johnson, DR, Young, R (2011). Toward best practices in analyzing datasets with missing data: comparisons and recommendations. Journal of Marriage and the Family 73, 926–945.Google Scholar
Johnson, W (2007). Genetic and environmental influences on behavior: capturing all the interplay. Psychological Review 114, 423–440.Google Scholar
Kendler, KS, Gardner, C, Dick, DM (2011). Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction. Psychological Medicine 41, 1507–1516.Google Scholar
Kenny, DA (2012). Measuring model fit (http://davidakenny.net/cm/fit.htm). Accessed January 2014.Google Scholar
Krueger, RF, Hicks, BM, Patrick, CJ, Carlson, SR, Iacono, WG, McGue, M (2002). Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. Journal of Abnormal Psychology 111, 411–424.Google Scholar
Larsson, H, Viding, E, Rijsdijk, FV, Plomin, R (2008). Relationships between parental negativity and childhood antisocial behavior over time: a bidirectional effects model in a longitudinal genetically informative design. Journal of Abnormal Child Psychology 36, 633–645.Google Scholar
Legrand, LN, Keyes, M, McGue, M, Iacono, WG, Krueger, RF (2008). Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior. Psychological Medicine 38, 1341–1350.Google Scholar
McGue, M, Iacono, WG, Krueger, R (2006). The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. Behavorial Genetics 36, 591–602.Google Scholar
Moffitt, TE (2005). The new look of behavioral genetics in developmental psychopathology: gene–environment interplay in antisocial behaviors. Psychological Bulletin 131, 533–554.Google Scholar
Moffitt, TE, Caspi, A, Rutter, M (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 62, 473–481.Google Scholar
Narusyte, J, Neiderhiser, JM, Andershed, AK, D'Onofrio, BM, Reiss, D, Spotts, E, Ganiban, J, Lichtenstein, P (2011). Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype–environment correlation. Journal of Abnormal Psychology 120, 365–376.Google Scholar
Neale, MC (2006). Mx: Statistical Modeling, 7th edn. Department of Psychiatry, Virginia Commonwealth University: Richmond, VA.Google Scholar
Neiderhiser, JM, Reiss, D, Hetherington, EM, Plomin, R (1999). Relationships between parenting and adolescent adjustment over time: genetic and environmental contributions. Developmental Psychology 35, 680–692.Google Scholar
Prescott, CA, Madden, PA, Stallings, MC (2006). Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. Behavior Genetics 36, 473–482.Google Scholar
Purcell, S (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research 5, 554–571.Google Scholar
Rhee, SH, Waldman, ID (2002). Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin 128, 490–529.Google Scholar
Riggio, HR (2004). Parental marital conflict and divorce, parent–child relationships, social support, and relationship anxiety in young adulthood. Personal Relationships 11, 99–114.Google Scholar
Robins, LM, Babor, T, Cottler, LB (1987). Composite International Diagnostic Interview: Expanded Substance Abuse Module. Authors: St Louis.Google Scholar
Seiffge-Krenke, I (2006). Leaving home or still in the nest? Parent–child relationships and psychological health as predictors of different leaving home patterns. Developmental Psychology 42, 864–876.CrossRefGoogle Scholar
Shelton, KH, Harold, GT, Fowler, TA, Rice, FJ, Neale, MC, Thapar, A, van den Bree, M (2008). Parent–child relations, conduct problems and cigarette use in adolescence: examining the role of genetic and environmental factors on patterns of behavior. Journal of Youth and Adolescence 37, 1216–1228.Google Scholar
Spiegelhalter, DJ, Best, NG, Carlin, BP, Van Der Linde, A (2002). Bayesian measures of model complexity and fit. Journal of the Royal Statistical Society: Series B (Statistical Methodology) 64, 583–640.Google Scholar
Spitzer, RL, Williams, JBW, Gibbon, M (1987). Structured Clinical Interview for DSM-III-R (SCID). New York State Psychiatric Institute, Biometrics Research: New York.Google Scholar
Tuvblad, C, Grann, M, Lichtenstein, P (2006). Heritability for adolescent antisocial behavior differs with socioeconomic status: gene–environment interaction. Journal of Child Psychology and Psychiatry 47, 734–743.Google Scholar
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