GABA and mood disorders

M. TAYLOR; Z. BHAGWAGAR; P. J. COWEN; T. SHARP

doi:10.1017/S0033291702006876

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A γ-aminobutyric acid (GABA)-ergic theory of mood disorders was proposed by Emrich and colleagues (1980) following observations of the efficacy of the GABAergic anticonvulsant, valproate, in the treatment of mania. Since then, increasing biochemical and pharmacological evidence from animal and human studies has supported the hypothesis that mood disorders are associated with abnormalities in brain GABA function.

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