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A family study of HLA antigens and other genetic markers in schizophrenia

Published online by Cambridge University Press:  09 July 2009

Peter McGuffin ,
Hilliard Festenstein  and
Robin Murray
Peter McGuffin*
Affiliation:
Institute of Psychiatry, London, Department of Immunology, London Hospital Medical School, London
Hilliard Festenstein
Affiliation:
Institute of Psychiatry, London, Department of Immunology, London Hospital Medical School, London
Robin Murray
Affiliation:
Institute of Psychiatry, London, Department of Immunology, London Hospital Medical School, London
*
lAddress for correspondence: Dr Peter McGuffin, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

HLA antigens and 19 other genetic marker systems were studied in 12 families containing 2 or more members diagnosed as schizophrenic. In contrast with previous reports we could exclude linkage between the disorder and HLA, and we found no evidence of linkage with Gm or Ge. The disagreement between our results and those of a previous study, which suggested linkage between HLA and schizophrenia, could not be explained on the basis of genetic heterogeneity within the disorder. The problems of performing a linkage study in the face of diagnostic uncertainty and an unknown mode of inheritance of the main trait are discussed, and the measures taken in attempts to overcome these difficulties are described. Despite present drawbacks, genetic marker studies hold future promise as a means of detecting major gene effects in schizophrenia and other familial psychiatric disorders.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 1 , February 1983 , pp. 31 - 43
Copyright
Copyright © Cambridge University Press 1983

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References

Baron, M. (1976). Albinism and schizophreniform psychosis: a pedigree study. American Journal of Psychiatry 133, 1070–1073.Google ScholarPubMed
BÖÖk, J. A., Wetterberg, L. &Modrzewska, K. (1978). Schizophrenia in a north Swedish geographical isolate, 1900–1977. Epidemiology, genetics and biochemistry. Clinical Genetics 14, 373–394.CrossRefGoogle Scholar
Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. (1980). Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics 32, 312–331.Google ScholarPubMed
Clarke, C. A. (1961). Blood groups and disease. Progress in Medical Genetics 1, 81–119.Google Scholar
Cook, P. J. L., Noades, J. E., Lomas, C. G., Buckton, K. E. & Robson, E. B. (1980). Exclusion mapping illustrated by the MNSS blood group. Annals of Human Genetics 44, 61–73.CrossRefGoogle ScholarPubMed
Constantinidis, J. K. (1958). Les marquers de chromosomes chez les schizophrènes et la recherche du linkage entre ces caractères et la schizophrènie par la methode de Penrose. Journal de Genetique Humaine 7, 189–242.Google Scholar
Czechowicz, A. S. & Paman, Y. L. (1972). ABO types and the aetiology of schizophrenia. Medical Journal of Australia i, 1252–1256.CrossRefGoogle Scholar
Dutta, R. N. & Jetley, J. K. (1973). Schizophrenia: its relationship with ABO and rhesus blood groups and with secretor/non-secretor status of ABH blood group specific substances. Indian Psychiatry 15, 131–135.Google Scholar
Edwards, J. H. (1960). The simulation of Mendelism. Acta Genetica 10, 63.Google ScholarPubMed
Elston, R. C., Kringlen, E. & Namboodri, K. K. (1973). Possible linkage relationship between certain blood groups and schizophrenia or other psychosis. Behavior Genetics 3, 101–106.CrossRefGoogle ScholarPubMed
Elston, R. C. & Campbell, M. A. (1970). Schizophrenia: evidence for a major gene hypothesis. Behavior Genetics 1, 101–106.CrossRefGoogle ScholarPubMed
Elston, R. C. & Lange, K. (1975). The prior probability of autosomal linkage. Annals of Human Genetics 38, 341.CrossRefGoogle ScholarPubMed
Elston, R. C. & Yelverton, K. C. (1975). General models for segregation analysis. American Journal of Human Genetics 27, 31–45.Google ScholarPubMed
Feighner, J. P., Robins, E., Gaze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 57–63.CrossRefGoogle ScholarPubMed
Festenstein, H. & Demant, P. (1978). HLA and H2: Current Topics in Immunology, No. 9. Edward Arnold: London.Google Scholar
Flemebaum, A. & Larson, J. W. (1976). ABO–Rh blood groups and psychiatric diagnosis: a critical review. Diseases of the Nervous System 37, 581–583.Google Scholar
Gaekwad, R. S., Niyogi, A. K. & Jaktian, R. (1972). ABO blood groups genes in schizophrenia and manic depressive psychosis. Indian Journal of Medical Science 26, 493–495.Google ScholarPubMed
Gottesman, I. I. & Shields, J. (1967). A polygenic theory of schizophrenia. Proceedings of the National Academy of Sciences 58, 199–205.CrossRefGoogle ScholarPubMed
Gottesman, I. I. & Shields, J. (1972). Schizophrenia and Genetics. A Twin Study Vantage Point. Academic Press: New York.Google Scholar
Gottesman, I. I. & Shields, J. (1982). Schizophrenia: The Epigenetic Puzzle. Cambridge University Press: Cambridge.Google Scholar
Green, J. R. & Woodrow, J. C. (1977). Sibling method for detecting HLA-linked genes in disease. Tissue Antigens 9, 31–35.CrossRefGoogle ScholarPubMed
Human Gene Mapping 6 (1982). Cytogenetics and Cell Genetics (in the press).CrossRefGoogle Scholar
Hodge, S. E. & Spence, M. A. (1982). Some epistatic two locus models of disease. II: The confounding for linkage and association. American Journal of Human Genetics 33, 396–406.Google Scholar
Irvine, D. G. & Miyashita, H. (1965). Blood types in relation to depression and schizophrenia. Canadian Medical Association Journal 92, 611–614.Google ScholarPubMed
James, J. (1971). Frequency in relatives for an all-or-none trait. Annals of Human Genetics 35, 47–59.CrossRefGoogle ScholarPubMed
Keats, B. J. B., Morton, N. E., Rao, D. C. & Williams, W. R. (1979). A Source Book for Linkage in Man. Johns Hopkins University Press: Baltimore.Google Scholar
Kety, S. S., Rosenthal, D., Wender, P. H. & Schulsinger, F. (1968). The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. In The Transmission of Schizophrenia (ed. Rosenthal, D. and Kety, S. S.), pp. 345–362. Pergamon: Oxford.Google Scholar
Khouri, P. J., Haier, R. J., Reider, R. O. & Rosenthal, D. (1980). A symptom schedule for the diagnosis of borderline schizophrenia. British Journal of Psychiatry 137, 145–147.CrossRefGoogle ScholarPubMed
Kringlen, E. (1967). Heredity and Environment in the Functional Psychoses. Heinemann: London.Google Scholar
Master, A. B. (1967). The distribution of blood groups in psychiatric illness. British Journal of Psychiatry 113, 1309–1315.CrossRefGoogle Scholar
Maynard-Smith, S., Penrose, L. S. & Smith, C. A. B. (1961). Mathematical Tables for Research Workers in Human Genetics. Churchill: London.Google Scholar
McGuffin, P. (1979). Is schizophrenia an HLA associated disease? Psychological Medicine 9, 721–728.CrossRefGoogle ScholarPubMed
McGuffin, P., Farmer, A. E. & Rajah, S. M. (1977). Blood groups in schizophrenia (unpublished study).Google Scholar
McGuffin, P., Farmer, A. E. & Yonace, A. H. (1981). HLA antigens and sub types of schizophrenia. Psychiatry Research 5, 115–122.CrossRefGoogle Scholar
McGuffin, P., Reveley, A. & Holland, A. (1982). Identical triplets: non-identical psychosis? British Journal of Psychiatry 140, 1–6.CrossRefGoogle ScholarPubMed
McKusick, V. A. (1978). Mendelian Inheritance in Man (5th edn). Johns Hopkins University Press: Baltimore.Google Scholar
Mednick, S. A. & Schulsinger, R. (1968). Some premorbid characteristics related to adult breakdown in children with schizophrenic mothers. In The Transmission of Schizophrenia (ed. Rosenthal, D. R. and Kety, S. S.), pp. 267–291. Pergamon: Oxford.Google Scholar
Mendlewicz, J., Massart-Guiot, T., Wilmotte, J. & Fleiss, J. L. (1974). Blood groups in manic depressive illness and schizophrenia. Diseases of the Nervous System 35, 39–61.Google ScholarPubMed
Morton, N. E. (1955). Sequential tests for the detection of linkage. American Journal of Human Genetics 7, 277–318.Google ScholarPubMed
Morton, N. E. (1956). The detection and estimation of linkage between the genes for elliptocytosis and Rh blood type. American Journal of Human Genetics 8, 80–96.Google ScholarPubMed
Morton, N. E. & Lalouel, J. M. (1981). Resolution of linkage for irregular phenotype systems. Human Heredity 31, 3–7.CrossRefGoogle ScholarPubMed
Morton, N. E. & MacLean, C. J. (1974). Analysis of familial resemblance. III: Complex segregational analysis of quantitative traits. American Journal of Human Genetics 26, 489.Google Scholar
O'Rourke, D. H., Gottesman, I. I., Suarez, B. K., Rice, J. & Reich, T. (1982). Refutation of the single locus model in the aetiology of schizophrenia. American Journal of Human Genetics 33, 630–649.Google Scholar
Ott, J. (1974). Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. American Journal of Human Genetics 26, 588–597.Google ScholarPubMed
Peterfy, G., Solyom, L., Kendal, A. G. & Twian, M. (1976). The relationship between ABO blood groups and schizophrenia. Canadian Psychiatric Association Journal 21, 303–307.CrossRefGoogle ScholarPubMed
Reich, T., Rice, J. & Cloninger, C. R. (1981). The detection of a major locus in the presence of multifactorial variation. In Genetic Strategies in Psychobiology and Psychiatry (ed. Gershon, E. S., Matthyse, S., Breaxfleld, X. O. and Claranello, R. D.). pp. 353–367. Boxwood Press: Pacific Grove, California.Google Scholar
Renwick, J. H. (1971). Progress in mapping human autosomes. British Medical Bulletin 25, 65–73.CrossRefGoogle Scholar
Slater, E. & Cowie, U. (1971). The Genetics of Mental Disorders. Oxford University Press: London.Google Scholar
Suarez, B., Hodge, S. & Reich, T. (1979). Is juvenile diabetes determined by a single gene closely linked to HLA? Diabetes 28, 527.CrossRefGoogle ScholarPubMed
Svejgaard, A., Platz, P., Ryder, L. P., Neilson, L. S. & Thomson, M. (1975). HLA and disease association: a survey. Transplant Review 22, 3–39.Google ScholarPubMed
Thomson, G. (1981). A review of the theoretical aspects of HLA and disease association. Theoretical Population Biology 20, 168–208.CrossRefGoogle Scholar
Turner, W. D. (1979). Genetic markers for schizotoxia. Biological Psychiatry 14, 177–205.Google Scholar
Volkers, W. S., Went, L. N., Vegter-Van Der Vlis, M., Harper, P. S. & Caro, A. (1980). Genetic linkage in Huntington's chorea. Annals of Human Genetics 44, 75–79.CrossRefGoogle ScholarPubMed
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar
Wyatt, R. J., Murphy, D. L., Belmaker, R., Cohen, S., Donnelly, C. H. & Pollin, W. (1973). Reduced monamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia. Science 179, 916–918.CrossRefGoogle Scholar