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Executive function and attention deficit hyperactivity disorder: stimulant medication and better executive function performance in children

Published online by Cambridge University Press:  01 May 1999

S. KEMPTON ,
A. VANCE ,
P. MARUFF ,
E. LUK ,
J. COSTIN  and
C. PANTELIS
S. KEMPTON
Affiliation:
Department of Psychological Medicine, Monash University; Maroondah Hospital Child and Adolescent Mental Health Service; Mental Health Research Institute of Victoria; Department of Psychiatry, University of Melbourne; and Swinburne University, Victoria, Australia
A. VANCE
Affiliation:
Department of Psychological Medicine, Monash University; Maroondah Hospital Child and Adolescent Mental Health Service; Mental Health Research Institute of Victoria; Department of Psychiatry, University of Melbourne; and Swinburne University, Victoria, Australia
P. MARUFF
Affiliation:
Department of Psychological Medicine, Monash University; Maroondah Hospital Child and Adolescent Mental Health Service; Mental Health Research Institute of Victoria; Department of Psychiatry, University of Melbourne; and Swinburne University, Victoria, Australia
E. LUK
Affiliation:
Department of Psychological Medicine, Monash University; Maroondah Hospital Child and Adolescent Mental Health Service; Mental Health Research Institute of Victoria; Department of Psychiatry, University of Melbourne; and Swinburne University, Victoria, Australia
J. COSTIN
Affiliation:
Department of Psychological Medicine, Monash University; Maroondah Hospital Child and Adolescent Mental Health Service; Mental Health Research Institute of Victoria; Department of Psychiatry, University of Melbourne; and Swinburne University, Victoria, Australia
C. PANTELIS
Affiliation:
Department of Psychological Medicine, Monash University; Maroondah Hospital Child and Adolescent Mental Health Service; Mental Health Research Institute of Victoria; Department of Psychiatry, University of Melbourne; and Swinburne University, Victoria, Australia
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Abstract

Background. Executive function deficits have been reported repeatedly in children with Attention Deficit Hyperactivity Disorder (ADHD). Stimulant medication has been shown to be effective in improving cognitive performance on most executive function tasks, but neuropsychological tests of executive function in this population have yielded inconsistent results. Methodological limitations may explain these inconsistencies. This study aimed to measure executive function in medicated and non-medicated children with ADHD by using a computerized battery, the Cambridge Neuropsychological Test Automated Battery (CANTAB), which is sensitive to executive function deficits in older patients with frontostriatal neurological impairments.

Methods. Executive function was assessed in 30 children with ADHD: 15 were stimulant medication naïve and 15 were treated with stimulant medication. These two groups were compared to 15 age, sex and IQ matched controls.

Results. The unmedicated children with ADHD displayed specific cognitive impairments on executive function tasks of spatial short-term memory, spatial working memory, set-shifting ability and planning ability. Impairments were also seen on spatial recognition memory and delayed matching to sample, while pattern recognition memory remained intact. The medicated children with ADHD were not impaired on any of the above executive function tasks except for deficits in spatial recognition memory.

Conclusions. ADHD is associated with deficits in executive function. Stimulant medication is associated with better executive function performance. Prospective follow-up studies are required to examine these effects.

Type
Research Article
Information
Psychological Medicine , Volume 29 , Issue 3 , May 1999 , pp. 527 - 538
Copyright
© 1999 Cambridge University Press

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