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Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites

Published online by Cambridge University Press:  09 July 2009

G. Kalsi
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
B. S. Mankoo
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
D. Curtis*
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
J. Brynjolfsson
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
T. Read
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
T. Sharma
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
P. Murphy
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
H. Petursson
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
H. M. D. Gurling
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
*
1 Address for correspondence: Dr D. Curtis, Genetics Section, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.

Synopsis

There have been previous reports of a 1q43;11q21 translocation cosegregating with schizophrenia and a 9p22;11q22.3 translocation cosegregating with manic depression. In addition, the genes for the dopamine D2 receptor and for tyrosinase both map to chromosome 11q. Three 11q DNA markers were used to investigate 23 pedigrees containing multiple cases of schizophrenia. Strongly negative lod scores were obtained, providing evidence against linkage over a 70 cM region which included both translocation sites and both candidate genes.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1995

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References

Arinami, T., Itokawa, M., Enguchi, H., Tagaya, H., Yano, S., Shimizu, H., Hamaguchi, H. & Toru, M. (1994). Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet 343, 703704.CrossRefGoogle ScholarPubMed
Asherson, P., Williams, N., Roberts, E., McGuffin, M. & Owen, M. (1994). DRD2 Ser311/Cys311 polymorphism in schizophrenia. Lancet 343, 1045.Google ScholarPubMed
Baron, M. (1976). Albinism and schizophreniform psychosis: a pedigree study. American Journal of Psychiatry 133, 10701073.Google ScholarPubMed
Barr, C. L., Kennedy, J. L., Pakstis, J., Wetterberg, L., Sjogren, B., Bierut, L., Gelenter, J., Hallmayer, J., Moises, H., Cavalli-Sforza, L. L. & Kidd, K. K. (1991). Progress in genome scan for linkage in schizophrenia. Psychiatric Genetics 2, 66.Google Scholar
Clarke, D. J. & Buckley, M. E. (1989). Familial association of albinism and schizophrenia. British Journal of Psychiatry 155, 551553.CrossRefGoogle ScholarPubMed
Cottingham, R. W., Idury, R. M. & Schaffer, A. A. (1993). Faster sequential genetic linkage computations. American Journal of Human Genetics 53, 252263.Google ScholarPubMed
Curtis, D. & Gurling, H. M. D. (1993). A procedure for combining two-point lod scores into a summary multipoint map. Human Heredity 43, 173185.CrossRefGoogle ScholarPubMed
Curtis, D. & Sham, P. C. (1994). Using risk calculation to implement an extended relative pair analysis. Annals of Human Genetics 58, 151162.CrossRefGoogle ScholarPubMed
Diehl, S., Su, Y., Bray, J., Burke, J., Inomata, T., MacLean, C., Marazita, M., Meyer, J., Murphy, B., Nie, L., Ni Nuallain, M., O'Neil, A., Ploughman, L., Shinkwin, R., Walsh, D. & Kendler, K. (1991). Linkage studies of schizophrenia: exclusion of candidate regions on chromosomes 5q and 11q. Psychiatric Genetics 2, 1415.Google Scholar
Fletcher, J. M., Evans, K., BaillieD., Byrd, P. D., Byrd, P., Hanratty, D., Leach, S., Julier, C., Gosden, J. R. & Muir, W. (1993). Schizophrenia-associated chromosome 11q21 translocation: identification of flanking markers and development of chromosome 11q fragment hybrids as cloning and mapping resources. American Journal of Human Genetics 52, 478490.Google ScholarPubMed
Gejman, P. V., Ram, A., Gelernter, J., Friedman, E, Cao, Q., Pickar, D., Blum, K., Noble, E. P. & Kranzler, H. R. (1994). No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. Journal of the American Medical Association 271, 204208.CrossRefGoogle ScholarPubMed
Gill, M., McGuffin, P., Parfitt, E., Mant, R., Asherson, P., Vallada, H., Collier, D., Powell, J., Taylor, C., Sargeant, M., Clements, A., Nanko, S., Whatley, S., Murrya, R. & Owen, M. (1992). A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Schizophrenia Research 6, 89.CrossRefGoogle Scholar
Gill, M., McGuffin, P., Parfitt, E., Mant, R., Asherson, P., Collier, D., Vallada, H., Powell, J. & Shaikh, S. (1993). A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychological Medicine 23, 2744.CrossRefGoogle Scholar
Grandy, D. K., Litt, M., Allen, L. J., Bunzow, J., Magenis, R. E. & Civelli, O. (1989). Dopamine D2 receptor maps to human chromosome 11q22–q23 and identifies a TaqI RFLP. Cytogenetics and Cell Genetics 51, 1007.Google Scholar
Hauge, X. Y., Grandy, D. K., Eubanks, J. H., Evans, G. A., Civelli, O. & Litt, M. (1991). Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics 10, 527530.CrossRefGoogle ScholarPubMed
Lathrop, G. M., Lalouel, J. M., Julier, C. & Ott, J. (1985). Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. American Journal of Human Genetics 37, 482498.Google ScholarPubMed
Lehner, T., Ott, J., Shah, T., Lofthouse, R., Poulter, M., Walsh, C., Crow, T. J., Boccio, A., Shields, G. & Delisi, L. E. (1992). Linkage analysis and sib pair test for linkage of schizophrenia with D11S35. Schizophrenia Research 6, 92.CrossRefGoogle Scholar
Litt, M., Sharma, V. & Luty, J. A. (1990). Dinucleotide repeat polymorphism at the D11S35 locus. Nucleic Acids Research 18, 5921.CrossRefGoogle ScholarPubMed
McGuffin, P., Owen, M. & Gill, M. (1992). Molecular genetics of schizophrenia. In Genetic Research in Psychiatry (ed, Mendlewicz, J. and Hippius, H.), pp. 2443. Springer–Verlag: Heidelberg.Google Scholar
Muir, W. J., Blackwood, D., St Clair, D., Coia, D., Walker, M., Baillie, D. & Hubbard, A. (1991 a). Linkage studies of the long arm of chromosome 11 in schizophrenia families. Psychiatric Genetics 2, 18.Google Scholar
Muir, W., Blackwood, D., St Clair, D., Walker, M., Baillie, D. & Hubbard, A. (1991 b). Linkage analysis of schizophrenia with polymorphic loci on chromosome 11q. Cytogenetics and Cell Genetics 58, 19661967.Google Scholar
NIH/CEPH Mapping Group (1992). A comprehensive genetic linkage map of the human genome. Science 258, 6786.CrossRefGoogle Scholar
Nanko, S., Gill, M., Owen, M., Takazawa, N., Moridaira, J. & Kazamatsuri, H. (1992). Linkage study of schizophrenia with markers on chromosome 11 in two Japanese pedigrees. Japanese Journal of Psychiatry and Neurology 46, 155159.Google ScholarPubMed
Nanko, S., Hattori, M., Dai, X. Y., Fukuda, R. & Kazamatsuri, H. (1994). DRD2 Ser311/Cys311 polymorphism in schizophrenia. Lancet 343, 1044.CrossRefGoogle ScholarPubMed
Nothen, M. M., Wildenauer, D., Cichon, S., Albus, M., Maier, W., Minges, M., Lichtermann, D., Bondy, B., Rietschel, M., Korner, J., Fimmers, R. & Propping, P. (1994). Dopamine D2 receptor molecular variant and schizophrenia. Lancet 343, 13011302.CrossRefGoogle ScholarPubMed
Ott, J. (1985). Analysis of Human Genetic Linkage. The Johns Hopkins University Press: Baltimore.Google Scholar
Sarkar, G., Kapelner, S., Grandy, D. K., Marchionni, M., Civelli, O., Sobell, J., Heston, L. & Sommer, S. S. (1991). Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics 11, 814.CrossRefGoogle ScholarPubMed
Schaffer, A. A., Gupta, S. K., Shriram, K. & Cottingham, R. W. (1994). Avoiding recomputation in genetic linkage analysis. Human Heredity 44, 225237.Google Scholar
Shaikh, S., Collier, D., Arranz, M., Ball, D., Gill, M. & Kerwin, R. (1994). DRD2 Ser311/Cys311 polymorphism in schizophrenia. Lancet 343, 10451046.Google ScholarPubMed
Sherrington, R., Brynjolfsson, J., PeturssonH, Potter, M. H, Potter, M., Dudleston, K., Barraclough, B., Wasmuth, J., Dobbs, M. & Gurling, H. (1988). Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164167,CrossRefGoogle ScholarPubMed
Smith, M., Wasmuth, J., McPherson, J. D., Wagner, C., Grandy, D., Civelli, O., Potkin, S. & Litt, M. (1989). Cosegregation of an 11q22.3–9.22 translocation with affective disorder: proximity of the dopamine D2 receptor relative to the translocation breakpoint. American Journal of Human Genetics (suppl) 45, A220.Google Scholar
Spitzer, R. L. & Endicott, J. (1977). The Schedule for Affective Disorders and Schizophrenia, Lifetime Version, 3rd edn.New York State Psychiatric Institute: New York.Google Scholar
SpitzerR. L, Endicott, J. R. L, Endicott, J. & Robins, E. (1978). Research Diagnostic Criteria for a Selected Group of Functional Disorders, 3rd edn.New York State Psychiatric Institute: New York.Google Scholar
Spritz, R. A., Strink, K. & King, R. A. (1989). Molecular analyses of the tyrosinase gene in patients with tyrosinase-deficient oculo-cutaneous albinism. American Journal of Human Genetics (suppl) 45, A221.Google Scholar
St Clair, D., Blackwood, D., Muir, W., Carothers, A., Walker, M., Spowart, G., Gosden, C. & Evans, H. J. (1990). Association within a family of a balanced autosomal translocation with major mental illness. Lancet 336, 1316.CrossRefGoogle ScholarPubMed
Su, Y., Burke, J., O'Neil, F. A., Murphy, B., Nie, L., Kipps, B., Bray, J., Shinkwin, R. & Ni-Nuallain, M. (1993). Exclusion of linkage between schizophrenia and the D2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families. Archives of General Psychiatry 50, 205211.Google ScholarPubMed
Wong, Z., Wilson, V., Patel, I., Royle, N. J., Povey, S. & Jeffreys, A. J. (1987). Characterisation of a panel of highly variable mini-satellites cloned from human DNA. Cytogenetics and Cell Genetics 46, 719.Google Scholar