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Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium

Published online by Cambridge University Press:  09 July 2009

G. J. Naylor ,
D. A. T. Dick  and
E. G. Dick
G. J. Naylor*
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
D. A. T. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
E. G. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
*
1Address for correspondence: Dr G. J. Naylor, Department of Psychiatry, University of Dundee.
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Synopsis

Biochemical studies of manic-depressive psychosis usually correlate biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time from the biochemical assay.

Erythrocyte sodium concentration, ouabain-sensitive potassium influx and Na-K ATPase were estimated in 11 patients before and after the cross-over point in a 2-year double blind clinical trial of lithium. Patients with the lowest erythrocyte Na-K ATPase and the highest flux sodium ATPase ratio tended to suffer most episodes of affective illness in the 2 years. Patients who had a low initial Na-K ATPase or a high initial flux sodium ATPase ratio, or in whom this ratio fell most with lithium or whose Na-K ATPase rose most with lithium, clinically responded best to lithium.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 2 , May 1976 , pp. 257 - 263
Copyright
Copyright © Cambridge University Press 1976

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References

REFERENCES

Abdulla, Y. J. & Hamadah, K. (1970). 3'-5' cyclic adenosine monophosphate in depression and mania. Lancet ii, 378–381.CrossRefGoogle Scholar
Ashcroft, G. W., Eccleston, D., Murray, L. G., Glen, A. I. M., Crawford, T. B. B., Pullar, I. A., Shields, P. J., Walter, D. S., Blackburn, I. M., Connechan, J. & Lonergan, M. (1972). Modified amine hypothesis for the aetiology of affective illness. Lancet ii, 573–577.Google Scholar
Carman, J. S., Post, R. M., Teplitz, T. A. & Goodwin, F. K. (1974). Divalent cations in predicting antidepressant response to lithium. Lancet ii, 1454.CrossRefGoogle Scholar
Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. S., Hare, E. H., Gardiner, R. & Maggs, R. (1971). Prophylactic lithium in affective disorders. Lancet ii, 275–279.CrossRefGoogle Scholar
Coppen, A. J. & Shaw, D. M. (1963). Mineral metabolism in melancholia. British Medical Journal ii, 1439–1444.CrossRefGoogle Scholar
Coppen, A. J., Shaw, D. M., Malleson, A. & Costain, R. (1966). Mineral metabolism in mania. British Medical Journal i, 71–75.CrossRefGoogle Scholar
Cundall, R. L., Brooks, P. W. & Murray, L. G. (1972). A controlled evaluation of lithium prophylaxis in affective disorders. Psychological Medicine 2, 308–311.CrossRefGoogle ScholarPubMed
Davies, B., Carroll, B. J. & Mowbray, R. M. (1972). Depressive Illness: Some Research Studies. Springfield, Ill.Google Scholar
Glen, A. I. M., Ongley, G. C. & Robinson, K. (1968) Diminished membrane transport in manic depressive psychosis and recurrent depression. Lancet ii, 241–243.CrossRefGoogle Scholar
Hokin-Naeverson, M., Spiegel, D. A. & Lewis, W. C. (1974). Deficiency of erythrocyte sodium pump activity in bipolar manic depressive psychosis. Life Sciences 15, 1739–1748.CrossRefGoogle Scholar
Melia, P. I. (1970). Prophylactic lithium; a double-blind trial in recurrent affective disorders. British Journal of Psychiatry 116, 621–624.CrossRefGoogle ScholarPubMed
Mendels, J. & Frazer, A. (1973). Intracellular lithium concentration and clinical response: towards a membrane theory of depression. Journal of Psychiatric Research 10, 9–18.CrossRefGoogle ScholarPubMed
Mendels, J. & Frazer, A. (1974). Alterations in cell membrane activity in depression. American Journal of Psychiatry 131, 1240–1246.Google ScholarPubMed
Mendels, J., Frazer, A., Secunda, S. K. & Stokes, J. W. (1971). Biochemical changes in depression. Lancet i, 448–449.CrossRefGoogle Scholar
Naylor, G. J., Dick, D. A. T., Le Poidevin, D. & Whyte, S. F. (1973). Erythrocyte membrane cation carrier in depressive illness. Psychological Medicine 4, 502–508.CrossRefGoogle Scholar
Naylor, G. J., Reid, A. H., Dick, D. A. T. & Dick, E. G. (1976). A biochemical study of short cycle manic depressive psychosis in mental defectives. British Journal of Psychiatry 128, 169–180.CrossRefGoogle ScholarPubMed
Naylor, G. J., Donald, J. M., Le Poidevin, D. & Reid, A. H. (1974). A double-blind trial of long-term lithium therapy in mental defectives. British Journal of Psychiatry 124, 52–57.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T. & Dick, E. G. Erythrocyte membrane cation carrier and mood fluctuations in normal subjects. In preparation.Google Scholar
Naylor, G. J., Dick, D. A. T., Dick, E. G. & Moody, J. P. (1974). Lithium therapy and erythrocyte membrane cation carrier. Psychopharmacologia 37, 81–86.CrossRefGoogle ScholarPubMed
Reid, A. H. (1972). Psychosis in adult mental defectives. 1. Manic depressive psychosis. British Journal of Psychiatry 120, 205–212.CrossRefGoogle Scholar
Serry, M. (1969). The lithium test. I. Clinical application and interpretation. Australia and New Zealand Journal of Psychiatry 3, 390–394.CrossRefGoogle ScholarPubMed
Stokes, J. W., Mendels, J., Secunda, S. K. & Dyson, W. L. (1972). Lithium excretion and therapeutic response. Journal of Nervous and Mental Disease 154, 43–48.CrossRefGoogle ScholarPubMed