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Electrophysiological evidence of the motivational salience of drug cues in opiate addiction

Published online by Cambridge University Press:  05 February 2007

DAN I. LUBMAN ,
NICHOLAS B. ALLEN ,
LESLEY A. PETERS  and
J. F. WILLIAM DEAKIN
DAN I. LUBMAN*
Affiliation:
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia Neuroscience and Psychiatry Unit, Department of Psychiatry, University of Manchester, UK
NICHOLAS B. ALLEN
Affiliation:
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia Department of Psychology, University of Melbourne, Australia
LESLEY A. PETERS
Affiliation:
Neuroscience and Psychiatry Unit, Department of Psychiatry, University of Manchester, UK
J. F. WILLIAM DEAKIN
Affiliation:
Neuroscience and Psychiatry Unit, Department of Psychiatry, University of Manchester, UK
*
*Address for correspondence: Dr D. I. Lubman, ORYGEN Research Centre, 35 Poplar Road, Parkville, Victoria 3052, Australia. (Email: [email protected])
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Abstract

Background

Drug-related stimuli reliably induce craving in experimental paradigms, yet are rarely cited by drug users as major precipitants of relapse. We examined the motivational significance of drug cues in opiate dependence, by exploring their impact on central attentional processes.

Method

Fourteen methadone-maintained subjects and 14 matched controls were studied. Subjects performed a novel active visual oddball task, consisting of opiate-related and matched neutral pictures, some of which (the oddballs) included a white cup. Subjects were fitted with a 32-channel electrode cap. The P300 for each stimulus category was identified using temporal principal components analysis.

Results

The P300 elicited by opiate stimuli was significantly larger than that elicited by neutral stimuli in the methadone-maintained group but not in the controls. There was also a non-significant trend for the opiate stimuli to elicit larger P300s than the oddball stimuli in the addicted group.

Conclusions

These results suggest that drug cues acquire motivational salience and automatically capture attentional resources in opiate addicts, even when engaged in a non-drug-related task. Enhanced P300s to drug cues may provide an important biological marker of crucial psychological mechanisms relevant to addiction.

Type
Original Article
Information
Psychological Medicine , Volume 37 , Issue 8 , August 2007 , pp. 1203 - 1209
Copyright
Copyright © Cambridge University Press 2007

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References

REFERENCES

Abbott, P. J., Weller, S. B. & Walker, S. R. (1994). Psychiatric disorders of opioid addicts entering treatment: preliminary data. Journal of Addictive Diseases 13, 1–11.CrossRefGoogle ScholarPubMed
Attias, J., Bleich, A., Firman, V. & Zinger, Y. (1996). Event-related potentials in post-traumatic stress disorder of combat origin. Biological Psychiatry 40, 373–381.CrossRefGoogle ScholarPubMed
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–585.CrossRefGoogle ScholarPubMed
Begleiter, H., Porjesz, B., Chou, C. L. & Aunon, J. I. (1983). P3 and stimulus incentive value. Psychophysiology 20, 95–101.CrossRefGoogle ScholarPubMed
Bradley, B. P., Phillips, G., Green, L. & Gossop, M. (1989). Circumstances surrounding the initial lapse to opiate use following detoxification. British Journal of Psychiatry 154, 354–359.CrossRefGoogle ScholarPubMed
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M. & O'Brien, C. P. (1999). Limbic activation during cue-induced cocaine craving. American Journal of Psychiatry 156, 11–18.CrossRefGoogle ScholarPubMed
Daglish, M. R. C., Weinstein, A., Malizia, A. L., Wilson, S., Melichar, J. K., Britten, S., Brewer, C., Lingford-Hughes, A., Myles, J. S., Grasby, P. & Nutt, D. J. (2001). Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects. American Journal of Psychiatry 158, 1680–1686.CrossRefGoogle ScholarPubMed
Dien, J. & Frishkoff, G. A. (eds) (2005). Principal Components Analysis of ERP Data. MIT Press: Cambridge, MA.Google Scholar
Franken, I. H. A., Kai, P. H., Stam, C. J., Hendriks, V. M. & van den Brink, W. (2004). Two new neurophysiological indices of cocaine craving: evoked brain potentials and cue modulated startle reflex. Journal of Psychopharmacology 18, 549–557.CrossRefGoogle ScholarPubMed
Franken, I. H. A., Kroon, L. Y. & Hendriks, V. M. (2000). Influence of individual differences in craving and obsessive cocaine thoughts on attentional processes in cocaine abuse patients. Addictive Behaviors, 25, 99–102.CrossRefGoogle ScholarPubMed
Franken, I. H. A., Stam, C. J., Hendriks, V. M. & van den Brink, W. (2003). Neurophysiological evidence for abnormal cognitive processing of drug cues in heroin dependence. Psychopharmacology 170, 205–212.CrossRefGoogle ScholarPubMed
Goldstein, R. Z. & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry 159, 1642–1652.CrossRefGoogle ScholarPubMed
Gossop, M. (1990). The development of a Short Opiate Withdrawal Scale (SOWS). Addictive Behaviors 15, 487–490.CrossRefGoogle Scholar
Gossop, M., Darke, S., Griffiths, P. & Hando, J. (1995). The Severity of Dependence Scale (SDS): psychometric properties of the SDS in English and Australian samples of heroin, cocaine and amphetamine users. Addiction 90, 607–614.CrossRefGoogle ScholarPubMed
Herrmann, M. J., Weijers, H. G., Wiesbeck, G. A., Aranda, D., Böning, J. & Fallgatter, A. J. (2000). Event-related potentials and cue reactivity in alcoholism. Alcoholism: Clinical and Experimental Research 24, 1724–1729.Google ScholarPubMed
Herrmann, M. J., Weijers, H. G., Wiesbeck, G. A., Boning, J. & Fallgatter, A. J. (2001). Alcohol cue-reactivity in heavy and light social drinkers as revealed by event-related potentials. Alcohol and Alcoholism 36, 588–593.CrossRefGoogle ScholarPubMed
Hester, R., Dixon, V. & Garavan, H. (2006). A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task. Drug and Alcohol Dependence 81, 251–257.CrossRefGoogle ScholarPubMed
Ito, T. A. & Urland, G. R. (2003). Race and gender on the brain: electrocortical measures of attention to race and gender of multiply categorizable individuals. Journal of Personality and Social Psychology 85, 616–626.CrossRefGoogle ScholarPubMed
Lubman, D. I., Peters, L. A., Mogg, K., Bradley, B. P. & Deakin, J. F. (2000). Attentional bias for drug cues in opiate dependence. Psychological Medicine 30, 169–175.CrossRefGoogle ScholarPubMed
Lubman, D. I., Yucel, M. & Pantelis, C. (2004). Addiction, a condition of compulsive behaviour? Neuroimaging and neuropsychological evidence of inhibitory dysregulation. Addiction 99, 1491–1502.CrossRefGoogle ScholarPubMed
Luck, S. J., Woodman, G. F. & Vogel, E. K. (2000). Event-related potential studies of attention. Trends in Cognitive Sciences 4, 432–440.CrossRefGoogle ScholarPubMed
Mason, B. J., Kocsis, J. H., Melia, D., Khuri, E. T., Sweeney, J., Wells, A., Borg, L., Millman, R. B. & Kreek, M. J. (1998). Psychiatric comorbidity in methadone maintained patients. Journal of Addictive Diseases 17, 75–89.CrossRefGoogle ScholarPubMed
McCusker, C. G. & Gettings, B. (1997). Automaticity of cognitive biases in addictive behaviours: further evidence with gamblers. British Journal of Clinical Psychology 36, 543–554.CrossRefGoogle ScholarPubMed
Miller, N. S. & Gold, M. S. (1994). Dissociation of ‘conscious desire’ (craving) from and relapse in alcohol and cocaine dependence. Annals of Clinical Psychiatry 6, 99–106.CrossRefGoogle ScholarPubMed
Mogg, K., Bradley, B. P., Field, M. & De Houwer, J. (2003). Eye movements to smoking-related pictures n smokers: relationship between attentional biases and implicit and explicit measures of stimulus valence. Addiction, 98, 825–836.CrossRefGoogle Scholar
Nelson, H. E. (1982). National Adult Reading Test (NART). NFER-Nelson: Windsor.Google Scholar
Pauli, P., Dengler, W., Wiedemann, G., Montoya, P., Flor, H., Birbaumer, N. & Buchkremer, G. (1997). Behavioral and neurophysiological evidence for altered processing of anxiety-related words in panic disorder. Journal of Abnormal Psychology 106, 213–220.CrossRefGoogle ScholarPubMed
Pritchard, W. S. (1981). Psychophysiology of P300. Psychological Bulletin 89, 506–540.CrossRefGoogle ScholarPubMed
Robbins, S. J. & Ehrman, R. N. (2004). The role of attentional bias in substance abuse. Behavioural and Cognitive Neuroscience Reviews 3, 243–260.CrossRefGoogle ScholarPubMed
Robinson, T. E. & Berridge, K. C. (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Research. Brain Research Reviews 18, 247–291.CrossRefGoogle ScholarPubMed
Sharma, D., Albery, I. P. & Cook, C. (2001). Selective attentional bias to alcohol related stimuli in problem drinkers and non-problem drinkers. Addiction, 96, 285–295.CrossRefGoogle ScholarPubMed
Spielberger, C. D., Gorsuch, R. L., Lushene, R., Vagg, P. R. & Jacobs, G. A. (1983). Manual for the State–Trait Anxiety Inventory. Consulting Psychologists Press: Palo Alto, CA.Google Scholar
Todd, T. C. (2005). Event-Related Potentials: A Methods Handbook. MIT Press: Cambridge.Google Scholar
van de Laar, M. C., Licht, R., Franken, I. H. & Hendriks, V. M. (2004). Event-related potentials indicate motivational relevance of cocaine cues in abstinent cocaine addicts. Psychopharmacology (Berlin) 177, 121–129.CrossRefGoogle ScholarPubMed
Wang, G. J., Volkow, N. D., Fowler, J. S., Cervany, P., Hitzemann, R. J., Pappas, N. R., Wong, C. T. & Felder, C. (1999). Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sciences 64, 775–784.CrossRefGoogle ScholarPubMed
Warren, C. A. & McDonough, B. E. (1999). Event-related potentials as indicators of smoking cue-reactivity. Clinical Neurophysiology 110, 1570–1584.CrossRefGoogle ScholarPubMed
WHO (1992). The ICD-10 Classification of Mental and Behavioural Disorders. World Health Organization: Geneva.Google Scholar