Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-04T19:37:07.757Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of antipsychotics on brain structure: what have we learnt from structural imaging of schizophrenia?

A commentary on ‘Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings’ by Navari & Dazzan (2009)

Published online by Cambridge University Press:  29 May 2009

S. J. Borgwardt ,
R. Smieskova ,
P. Fusar-Poli ,
K. Bendfeldt  and
A. Riecher-Rössler
S. J. Borgwardt*
Affiliation:
Psychiatric Outpatient Department, University Hospital Basel, Switzerland Medical Image Analysis Centre, University Hospital Basel, Switzerland Section of Neuroimaging, King's College London, Institute of Psychiatry, London, UK
R. Smieskova
Affiliation:
Psychiatric Outpatient Department, University Hospital Basel, Switzerland Medical Image Analysis Centre, University Hospital Basel, Switzerland
P. Fusar-Poli
Affiliation:
Section of Neuroimaging, King's College London, Institute of Psychiatry, London, UK
K. Bendfeldt
Affiliation:
Medical Image Analysis Centre, University Hospital Basel, Switzerland
A. Riecher-Rössler
Affiliation:
Psychiatric Outpatient Department, University Hospital Basel, Switzerland
*
*Address for correspondence: Dr S. J. Borgwardt, Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4, CH-4031Basel, Switzerland. (Email: [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

AntipsychoticsARMSbrain structureMRIschizophrenia
Type
Commentary
Information
Psychological Medicine , Volume 39 , Issue 11 , November 2009 , pp. 1781 - 1782
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Borgwardt, SJ, McGuire, PK, Aston, J, Gschwandtner, U, Pfluger, MO, Stieglitz, RD, Radue, EW, Riecher-Rossler, A (2008). Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophrenia Research 106, 108–114.CrossRefGoogle ScholarPubMed
DeLisi, LE (2008). Reviewing the ‘facts about schizophrenia’: a possible or impossible task? Schizophrenia Research 102, 19–20.CrossRefGoogle ScholarPubMed
Fusar-Poli, P, Perez, J, Broome, M, Borgwardt, S, Placentino, A, Caverzasi, E, Cortesi, M, Veggiotti, P, Politi, P, Barale, F, McGuire, P (2007). Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 31, 465–484.CrossRefGoogle ScholarPubMed
Job, DE, Whalley, HC, Johnstone, EC, Lawrie, SM (2005). Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage 25, 1023–1030.CrossRefGoogle ScholarPubMed
Konopaske, GT, Dorph-Petersen, KA, Sweet, RA, Pierri, JN, Zhang, W, Sampson, AR, Lewis, DA (2008). Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biological Psychiatry 63, 759–765.CrossRefGoogle ScholarPubMed
Navari, S, Dazzan, P (2009). Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychological Medicine. Published online: 2 April 2009. doi:10.1017/S0033291709005315.CrossRefGoogle ScholarPubMed
Pantelis, C, Velakoulis, D, McGorry, PD, Wood, SJ, Suckling, J, Phillips, LJ, Yung, AR, Bullmore, ET, Brewer, W, Soulsby, B, Desmond, P, McGuire, PK (2003). Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361, 281–288.CrossRefGoogle ScholarPubMed
Riecher-Rossler, A, Gschwandtner, U, Aston, J, Borgwardt, S, Drewe, M, Fuhr, P, Pfluger, M, Radu, W, Schindler, C, Stieglitz, RD (2007). The Basel early-detection-of-psychosis (FEPSY) study – design and preliminary results. Acta Psychiatrica Scandinavica 115, 114–125.CrossRefGoogle ScholarPubMed
Smieskova, R, Fusar-Poli, P, Allen, P, Bendfeldt, K, Stieglitz, RD, Drewe, J, Radu, EW, McGuire, PK, Riecher, A, Borgwardt, SJ (in press). The effects of antipsychotics on the brain: What have we learnt from structural neuroimaging of schizophrenia? – a systematic review. Current Pharmaceutical Design.Google Scholar
Wood, SJ, Pantelis, C, Velakoulis, D, Yucel, M, Fornito, A, McGorry, PD (2008). Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophrenia Bulletin 34, 322–329.CrossRefGoogle ScholarPubMed