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Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression

Published online by Cambridge University Press:  23 December 2002

C. K. LOO ,
P. B. MITCHELL ,
V. M. CROKER ,
G. S. MALHI ,
W. WEN ,
S. C. GANDEVIA  and
P. S. SACHDEV
C. K. LOO
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
P. B. MITCHELL
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
V. M. CROKER
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
G. S. MALHI
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
W. WEN
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
S. C. GANDEVIA
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
P. S. SACHDEV
Affiliation:
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales and Prince of Wales Medical Research Institute, Sydney, NSW, Australia
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Abstract

Background. The efficacy and safety of bilateral prefrontal repetitive transcranial magnetic stimulation (rTMS) for treating resistant major depression were examined in a double-blind, placebo-controlled study.

Method. Nineteen medication-resistant depressed subjects were randomly assigned to 3 weeks of active or sham rTMS. Effects on mood and neuropsychological function were assessed.

Results. Both groups improved significantly in mood over the 3 weeks, but there was no significant difference between active and sham treatments. There were no significant neuropsychological effects.

Conclusions. Bilateral rTMS was not superior to sham in treating resistant depression in this pilot study, but caused no neuropsychological impairment.

Type
Research Article
Information
Psychological Medicine , Volume 33 , Issue 1 , January 2003 , pp. 33 - 40
Copyright
© 2003 Cambridge University Press

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